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In response to concerns about the safety of Molnupiravir, an oral antiviral medication licenced to treat Covid-19, Indian health officials have stated that the drug's advantages outweigh the hazards it may pose in high-risk patients.
The Medicines and Healthcare Products Regulatory Agency (MHRA) in the United Kingdom has licenced it for the treatment of mild-to-moderate Covid-19 in individuals with a high risk of severe disease development, namely those with pre-existing (comorbid) diseases.
The medicine has also been licenced in India, which is seeing an increase in instances of the new Covid version Omicron. The antiviral Molnupiravir was recently licenced for limited usage in emergency conditions by an expert panel of the Central Drugs Standard Control Organization. Thirteen Indian businesses will produce the antiviral medication.
However, according to Balram Bhargava, Director General of the Indian Council of Medical Research (ICMR), Molnupiravir is not included in the national Covid taskforce regimen because of serious safety issues like as teratogenicity, mutagenicity, muscle and bone damage, and others.
"More critically, if this treatment is administered to both male and females, contraception must be used for three months since the kid born may have teratogenic consequences," he added at a news conference.Medical experts, on the other hand, have stated that the drug's advantages outweigh any possible concerns it may pose in high-risk individuals.
However, they argue that because there are few alternatives for treating Covid patients, the new authorised drugs should be given a chance under stringent treatment procedures.
"When prescribing any medicine, physicians must bear in mind their patient profiles." If the patient is high-risk, meaning he or she is over 60 years old, obese, or has cardiovascular disease, hypertension, and/or chronic lung, renal, or liver illness, ignoring treating the condition while it is mild or moderate might lead to serious consequences, including hospitalisation.
Dr. Deepak Talwar, Senior Consultant, Pulmonology and Sleep Medicine, and Chairman, Metro Respiratory Centre, said, "As we saw with the Delta variety, even death is a possibility."
"Rather than calculating its negative effects, which are also probable but unknown," he continued, "we need to employ the current therapy."
He reviewed the drug's safety data before approving it.Youtube/wikipedia
According to Dr. Dhruva Chaudhry, Head Of Pulmonary and Critical Care Medicine at PGIMS, Rohtak, the US FDA and the DCGI reviewed the drug's safety data before approving it. "This medicine will only be authorised after all of the conditions are met."
"Even in phase 3 clinical studies, as compared to the placebo group, Molnupiravir revealed a substantial reduction in the risk of hospitalisation or death with no recognised safety issues," Chaudhry added.
Molnupiravir stops specific RNA viruses from replicating. It will primarily be used to treat Covid-19-infected adults over the age of 50, as well as those with several comorbidities. Molnupiravir 800 mg twice a day for five days is the recommended dosage. A patient must take 40 capsules with a total dose of 200 mg of medicine.
The oral tablet is being developed by more than a dozen pharmaceutical firms, including Torrent, Cipla, Sun Pharma, Dr. Reddy's, Natco, Mylan, and Hetero. Molnupiravir pills are also scheduled to be released in the following weeks by Cipla, Sun Pharma, and Dr Reddy's Laboratories.
(keywords: Molnupiravir, RNA viruses, Covid-19 Virus, Torrent, Cipla, Sun Pharma, Dr. Reddy's, Natco, Mylan, and Hetero, Dr. Dhruva Chaudhry,
There will be no chief guest at the Republic Day parade this year also as the plan to host state heads of five Central Asian countries -- Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan and Uzbekistan -- seems to have been cancelled due to the Covid situation in India as well as in the respective nations. Though the Ministry of External Affairs is yet to confirm this officially.
If the guests arrive, then this would be the second time when India hosts a group of state heads as the chief guests on the Republic Day. In 2018, state heads of ASEAN countries graced the occasion with their presence. Apart from Kazakhstan, none of these countries' state heads had been invited as the chief guests on the Republic Day. In 2009, Kazakhstan's then president Nursultan Nazarbayev was the Chief Guest.
The Government of India is in no mood to take any risk to invite any foreign guest. Mitul Gajera / Unsplash
As per sources, due to the corona situation, the Government of India is in no mood to take any risk to invite any foreign guest, so the plan seems to have been cancelled. Last year, British Prime minister Boris Johnson was invited for the same, but later cancelled due to rising corona cases in the UK.
In the past, there have been occasions when the Republic Day ceremony was celebrated without any foreign guest. In 1966, there was no foreign chief guest in the Republic Day parade ceremony as the then Prime Minister Lal Bahadur Shastri had passed away in Tashkent in January, and Indira Gandhi took oath as Prime Minister on January 24. (IANS/SP)
(Keywords : chief, guest, Republic Day, parade, India, January, pandemic, 2022, host, nation, guest, invite, foreign, occasion, presence, celebrate.)
A team of scientists from the Banaras Hindu University (BHU) have found a cure for those suffering from chronic wounds, particularly with diabetic foot ulcers. The team led by Prof Gopal Nath of the department of Microbiology, Institute of Medical Sciences, said that wounds that took months and years to heal, could now be cured in days or months. The findings of study have been published in the National Centre for Biotechnology Information, National Institutes of Health, US.
Prof Nath said that a wound is defined as a breach in the skin or body tissues due to injury. An acute wound is defined as a "recent break that is yet to progress through sequential stages of healing". The wounds where normal healing process is stalled due to underlying pathology (vascular and diabetes) or infection beyond three months is defined as chronic wound. While chronic wounds always get infected, the contaminated wounds are reasonably susceptible to infection.
A significant improvement could be achieved in the form of complete wound epithelization within a few weeks.Towfiqu barbhuiya / Unsplash
Infection with antibiotic-resistant bacteria and biofilm formation halt healing progress. These wounds cause significant psychological and physical morbidity. The traditional treatment strategies often succeed in healing wounds, he said adding that many wounds have been observed recalcitrant to them, leading to persistence and recurrent infections. Search for alternatives to antibiotics has now become a compulsion. Fortunately, bacteriophage therapy is a re-emerging solution to antibiotic-resistant bacteria.
Prof Nath's team carried out phage therapy of acute and chronic infected wounds in animals and clinical studies. It showed efficacy against Pseudomonas aeruginosa in a mice wound model. Furthermore, they evaluated the efficacy of phage cocktails in animal models' acute and chronic osteomyelitis caused by methicillin-resistant Staphylococcus aureus. They also observed biofilm eradication from K wire in rabbits' wound infection model. Clinical trials of phage therapy initiated by the BHU have reported the efficacy of topical phage in healing chronic wounds in three prospective exploratory studies and no adverse events mimicking the results in vivo animal models.
Scientists have found a cure for those suffering from diabetic foot ulcers. Unsplash
A clinical study by Gupta demonstrated the significant role of bacteriophage therapy in the chronic wounds associated with antibiotic-resistant bacteria. The study employed a total of twenty patients with chronic non-healing ulcers for more than six weeks duration. A significant improvement could be achieved in the form of complete wound epithelization within a few weeks. Another study, employing 48 patients having a minimum of one eligible full-thickness wound that did not heal in six weeks with convention wound management, showed the promising result, and significant improvement was observed in the wound healing.
The study projected that specific phage therapy is equally effective regardless of the diabetic or non-diabetic status of the patient though the healing was relatively delayed in diabetic patients. Another successful study has shown encouraging results on healing process of infected acute traumatic wounds. The average number of days required for complete granulation of wounds and attaining sterility and healing was half compared to conventional therapy. (IANS/SP)
(Keywords : scientists, cure, chronic, wound, suffer, ulcer, diabetes, healing, pathology, health, infection, bacteria, study, patient, therapy, successful.)
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By Anna Melnikova
The Indian cricket lovers have been waiting for a ton from Virat Kohli for a long time, and he finally has made it. However, not in the batting as most fans expect, but in catching balls.
The second day of the 3rd Test in Capetown between local Proteas and the Men in Blue was rich for interesting occasions. Thus, South Africa was waiting for a good scoring result after stopping all Indian batters on the first day. Their opponents, however, have been looking for nice bowling not to lose the game just in the first innings. And while Bumrah added five wickets to his score, one of the dismissals should go to Virat Kohli. By the way, if you want more cricket news in India, we recommend subscribing to the specified site using the link.
Also Read : Acts of good sportsmanship
The legendary captain was great in batting but now can not score a ton for more than two years. But the three-digit result came from another side, where he is also quite successful. And while most of his catches came from opponents' misses, he proved he can be effective in the outfield parts of the pitch. According to experts, Kohli has a unique ability to be energetic on the pitch and still be concentrated for long shots by opponents, which rarely come in Test format.
Kohli has a unique ability to be energetic on the pitch. Unsplash
Even a legendary Gavaskar, who was the first Indian with such a result, praised the ability of the recent captain to catch. He admitted the ability to grab slipping balls, which are hard to cope with. Interestingly, Virat became only the sixth Indian to achieve a milestone in this component in the Test format. Kohli needed 99 games to find the needed number, although he is focused on making the 28th century first of all.
Another three-digit achievement can happen just today. He opened the 3rd day of the Test in Capetown along with Pujara and stayed alive at the moment of writing this article. If you are fond of sports betting, we recommend that you go to the rating of sports betting sites in India and choose a reliable bookmaker.
(Disclaimer: This is a sponsored article and includes some commercial links.)
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