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More about Big Bang? China to set up World’s Highest Altitude Gravitational Wave Telescope in Tibet

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In China, Pixabay

Lhasa, Jan 7, 2017: China is working to set up the world’s highest altitude gravitational wave telescopes in Tibet Autonomous Region to detect the faintest echoes resonating from the universe, which may reveal more about the Big Bang.

Construction has started for the first telescope, code-named Ngari No.1, 30 km south of Shiquanhe town in Ngari Prefecture, said Yao Yongqiang, chief researcher with the National Astronomical Observatories of the Chinese Academy of Sciences, Xinhua news agency reported.

The telescope, located 5,250 meters above sea level, will detect and gather precise data on primordial gravitational waves in the Northern Hemisphere.

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It is expected to be operational by 2021.

Yao said the second phase involves a series of telescopes, code-named Ngari No. 2, to be located about 6,000 meters above sea level. He did not give a time frame for construction of Ngari No. 2.

The budget for the two-phase Ngari gravitational wave observatory is an estimated 130 million yuan ($18.8 million). The project was initiated by the Institute of High Energy Physics, National Astronomical Observatories, and Shanghai Institute of Microsystem and Information Technology, among others.

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Ngari, with its high altitude, clear sky, and minimal human activity, is said to be one of the world’s best spots to detect tiny twists in cosmic light.

Yao said the Ngari observatory will be among the world’s top primordial gravitational wave observation bases, alongside the South Pole Telescope and the facility in Chile’s Atacama Desert.

Gravitational waves were first proposed by Albert Einstein’s theory of general relativity 100 years ago, but it wasn’t until 2016 that scientists with the Laser Interferometer Gravitational-Wave Observatory announced proof of the waves’ existence, spurring fresh research interest among the world’s scientists.

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China has announced its own gravitational wave research plans, which include the launch of satellites and setting up FAST, a 500-meter aperture spherical radio telescope in southwest China’s Guizhou Province. (IANS)

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Heart Rate Gets Altered in Space But Returns to Normal on Earth

Upon return to Earth, space-flown heart cells show normal structure and morphology

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Heart Rate
Relatively little is known about the role of microgravity in influencing human Heart Rate at the cellular level. Pixabay

Heart Rate gets altered in space but return to normal within 10 days on Earth, say researchers who examined cell-level cardiac function and gene expression in human heart cells cultured aboard the International Space Station (ISS) for 5.5 weeks.

Exposure to microgravity altered the expression of thousands of genes, but largely normal patterns of gene expression reappeared within 10 days after returning to Earth, according to the study published in the journal Stem Cell Reports.

“We’re surprised about how quickly human heart muscle cells are able to adapt to the environment in which they are placed, including microgravity,” said senior study author Joseph C. Wu from Stanford University.

These studies may provide insight into cellular mechanisms that could benefit astronaut health during long-duration spaceflight, or potentially lay the foundation for new insights into improving heart health on Earth.

Past studies have shown that spaceflight induces physiological changes in cardiac function, including reduced heart rate, lowered arterial pressure, and increased cardiac output.

But to date, most cardiovascular microgravity physiology studies have been conducted either in non-human models or at tissue, organ, or systemic levels.

Relatively little is known about the role of microgravity in influencing human cardiac function at the cellular level.

Heart Rate
Heart Rate gets altered in space but return to normal within 10 days on Earth, say researchers who examined cell-level cardiac function and gene expression in human heart cells cultured aboard the International Space Station (ISS) for 5.5 weeks. Pixabay

To address this question, the research team studied human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). They generated hiPSC lines from three individuals by reprogramming blood cells, and then differentiated them into heart cells.

Beating heart cells were then sent to the ISS aboard a SpaceX spacecraft as part of a commercial resupply service mission.

Simultaneously, ground control heart cells were cultured on Earth for comparison purposes.

Upon return to Earth, space-flown heart cells showed normal structure and morphology. However, they did adapt by modifying their beating pattern and calcium recycling patterns.

In addition, the researchers performed RNA sequencing of heart cells harvested at 4.5 weeks aboard the ISS, and 10 days after returning to Earth.

These results showed that 2,635 genes were differentially expressed among flight, post-flight, and ground control samples.

Most notably, gene pathways related to mitochondrial function were expressed more in space-flown heart cells.

A comparison of the samples revealed that heart cells adopt a unique gene expression pattern during spaceflight, which reverts to one that is similar to groundside controls upon return to normal gravity, the study noted.

Heart Rate
Past studies have shown that spaceflight induces physiological changes in cardiac function, including reduced Heart Rate, lowered arterial pressure, and increased cardiac output. Pixabay

According to Wu, limitations of the study include its short duration and the use of 2D cell culture.

In future studies, the researchers plan to examine the effects of spaceflight and microgravity using more physiologically relevant hiPSC-derived 3D heart tissues with various cell types, including blood vessel cells.

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“We also plan to test different treatments on the human heart cells to determine if we can prevent some of the changes the heart cells undergo during spaceflight,” Wu said. (IANS)