Sunday January 26, 2020

Mucous Tissues’ Wound Healing Might Prevent AIDS: Study

Wound healing in mucous tissues might prevent AIDS, says a new study

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The wound healing process of the mucous tissues can help fight HIV and prevent AIDS. Pixabay

Wound healing events in mucous tissues during early infection by Simian Immunodeficiency Virus, or SIV, guard some primate species against developing AIDS, a new study has learned.

The research, published in the journal Nature Communications, looked at why certain species can carry the virus throughout their lives, and still avoid disease progression.

SIV is closely related to the Human Immunodeficiency Virus (HIV). It is used as a laboratory model for many studies seeking AIDS and HIV cures and preventions.

“We think the regenerative wound healing process likely preserves the tissue integrity, and could prevent the inflammatory insults that underlie immune exhaustion, cell death and AIDS that happen due to SIV or HIV infection,” said study researcher Michael Gale, Professor at the University of Washington in the US.

In this latest study, scientists sought to uncover, in natural hosts, successful virus-fighting tactics that could inform the design of better antiviral drugs to treat HIV in people.

The research team combined data from their experiments and from other published studies to generate their findings.

To evaluate the virus-host interactions and immune response in the early stages of the SIV and HIV infection, the researchers developed a systems biology approach — a way of representing and interpreting complex interactions — called Conserved Gene Signature Analysis.

They also conducted additional types of bioinformatics analyses, which incorporate methods and tools from computer science, biology, mathematics, statistics, information engineering and other fields.

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Stimulation of the wound healing response during early infection could have a protective effect against disease like AIDS from the HIV infection. Pixabay

As part of their study, the researchers compared virus host interactions and immune response to SIV, including gene expression profiles, from the African green monkey, a natural host for HIV, with those from an AIDS-susceptible species, the rhesus macaque.

Similar data from human HIV infections was also evaluated.

The researchers explained that both HIV and SIV infect immune cells called T helper cells. These cells are abundant in the intestine and in specialised tissues elsewhere in the body.

The researchers found that, in contrast, African green monkeys in the early stages of SIV infection quickly activate and maintain regenerative wound healing mechanism in their mucosal tissue.

For example, in the monkeys, a white-cell mediated remodeling of tissue occurs. Some of the repair mechanisms, the researchers say, are evolutionarily conserved. One biological pathway, for instance, is roughly reminiscent of one observed in a salamander that can regenerate certain lost parts.

Also Read- Researchers Develop New Tool That Can Detect Cancer

The green monkey’s ability to activate mucous tissue wound healing, the research team found, interrupts the course of the disease such that the onset of AIDS is avoided.

“Our findings indicate that the use of therapies that stimulate the wound healing response during early infection could have a protective effect against disease from the HIV infection,” Gale said. (IANS)

Next Story

Women Tend to Get Better Sleep Than Men: Report

19% of Indian women have menstrual problems says a new lifestyle report

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A new fitness report suggests that women have a better sleep than men. Pixabay

A new fitness report has suggested that close to 19 per cent of women suffer from some kind of menstrual issues which is one of the lifestyle diseases.

The GOQii India Fit Report 2020, that was recently launched had reported an uptick in lifestyle diseases like thyroid and diabetes in India. Specifically for women’s health, it revealed that women walk less than men, with an average of 7,117 steps a day, whereas the average man walks 7416 daily steps – almost 300 steps more.

Speaking of sleeptime, Indians get 6 hours and 52 minutes of overall sleep on average per day, with 4 hrs and 53 mins hours of sound sleep. However, as per the report, women tend to get better sleep than men.

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The report also suggests that men stay more hydrated than women. Pixabay

On the other hand, men are more hydrated than women. The report also suggests top ways to maintain feminine hygiene:

Keep the vagina clean by washing regularly with a gentle, mild soap and warm water.

Never use scented soaps and feminine products or douche. Also, avoid feminine sprays and bubble baths.

Also Read- Here’s how Low-Dose Aspirin may Help Mothers Lower the Risk of Preterm Birth

After going to the bathroom, always wipe from front to back to prevent bacteria from getting into the vagina and causing an infection.

Wear 100 percent cotton underpants, and avoid overly tight clothing. (IANS)