Monday December 17, 2018

Learn How Muscles Help Burn Fat During Exercise

Burning fat is likely to impact multiple aspects of metabolic health related to diabetes, heart disease and other conditions

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How exercise can help breast cancer survivors. Pixabay
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Ever thought what helps burn fat across your body while exercising? According to a study, it is a molecule in our muscles that is produced during exercise and contributes to the beneficial effects of exercise on metabolism.

“Our finding bolsters the underlying notion that signals generated in exercising muscle are released into the circulation and influence other tissues such as fat cells and liver,” said senior author Robert Gerszten at Massachusetts General Hospital, the primary teaching hospital of Harvard Medical School.

The researchers knew that a protein called PGC-1? regulates metabolic genes in muscle and contributes to the response of muscle to exercise.

But how this protein conveys signals to other tissues was unclear so far.

Gerszten and his colleagues forced the expression of PGC-1? in muscle cells and then looked for metabolites that were secreted from the cells.

Exercise
BAIBA also decreased weight gain and helped balance blood sugar levels in mice, said the study published in the journal Cell Metabolism. Pixabay

They identified ?-aminoisobutyric acid (BAIBA) as one such metabolite and found that it increased fat cells’ expression of genes that are involved with burning calories.

BAIBA also decreased weight gain and helped balance blood sugar levels in mice, said the study published in the journal Cell Metabolism.

Further research revealed that BAIBA levels rise during exercise and are inversely associated with metabolic risk factors.

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“The findings suggest that BAIBA may contribute to exercise-induced protection from metabolic diseases. Manipulating BAIBA – or enzymes that generate BAIBA – may have therapeutic potential,” said Gerszten.

Burning fat is likely to impact multiple aspects of metabolic health related to diabetes, heart disease and other conditions, the study concluded.  (IANS)

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Here’s How Exercise Can Help Breast Cancer Survivors

Among those who completed the program, those who received the lifestyle intervention were about 50 per cent more likely to have disease-free survival than those who received the general recommendations

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How exercise can help breast cancer survivors. Pixabay

Survivors of early-stage breast cancer who exercise and eat a healthy diet are more likely to lose weight and experience higher rates of disease-free survival, a new study suggests.

The research is based on an examination of a lifestyle intervention that included exercise, diet, and at least one other component such as counselling, stress management, and discontinuing tobacco smoking.

The study showed that obesity and low physical activity are associated with higher risks of developing breast cancer, as well as an increased risk of recurrence and reduced survival.

“Lifestyle intervention might improve the prognosis of breast cancer patients if adherence is high,” said Wolfgang Janni from the University of Ulm in Germany.

“Many breast cancer survivors would like to contribute actively to improving their prognosis, and guiding them on lifestyle factors that can help them control weight is one possible way to positively impact patient outcomes,” said Janni.

For the study, the researchers enrolled 2,292 women among which all had a body mass index of 24 or higher.

Cancer
Cancer Ribbon. Pixabay

Some women were randomly assigned to receive either telephone-based lifestyle intervention for two years while others received general recommendations for a healthy lifestyle alone.

Those who received the telephone calls were given advice on how to improve their diets, lower fat intake, increase physical activity, achieve moderate weight loss and other tips that were geared to their specific needs.

Findings, presented at the 2018 San Antonio Breast Cancer Symposium in the US, demonstrated that patients in the lifestyle intervention arm had lost an average of one kg, while the patients in the control group had gained an average of 0.95 kg.

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Overall, 1,477 patients completed the lifestyle intervention. Those who completed the program had a 35 per cent higher rate of disease-free survival than those who began the program but did not complete it.

Among those who completed the program, those who received the lifestyle intervention were about 50 per cent more likely to have disease-free survival than those who received the general recommendations. (IANS)