Thursday July 18, 2019

Researchers Develop Nano Technology That Offers Hope For Better Cancer Testing

The study has been published in the journal Advanced Materials

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Breast Cancer
Nano technology offers hope for better cancer testing. Pixabay

Researchers have designed a new nano tool which could become a new way of mining blood samples for information about cancer, according to a study released on Wednesday by the University of Manchester.

Minimally invasive blood tests have the potential to detect and monitor life-threatening diseases such as cancer. But the markers released into the bloodstream as a response to a disease are often difficult to detect because they are too small and too few in number, Xinhua news agency reported.

The study, led by researchers from the University of Manchester showed that small molecules — specifically proteins — stick to the nanoparticles while in the blood circulation of cancer patients. Collecting the nanoparticles from the blood can then allow the analysis of the sticky molecules, some of which are released from the growing cancer.

Cancer
Cancer Ribbon. Pixabay

“We want to amplify cancer signals in the blood that would otherwise be buried among all this other ‘molecular noise’,” said study author Prof Kostas Kostarelos from Manchester.

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“Our team hopes to discover panels of biomolecules that can point to early warning signs of cancer which will provide the basis for the development of new diagnostic tests”, said Prof Kostarelos.

The study has been published in the journal Advanced Materials. (IANS)

Next Story

Researchers Find Way to Make Cancer Cells Self-destruct

It also shows that ATF4 turns on the genes MYC needs for growth and also controls the rate at which cells make specific proteins called 4E-BP

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Cancer, Patients, Invasive
Traditional treatments often include chemotherapy or radiation to kill cancer cells and shrink tumors. Pixabay

In a new hope for cancer patients, researchers have found a way to cause some cancer cells to self-destruct.

The research team has identified a new pathway that works as a partner to a gene called MYC which controls normal cell growth, but when it is mutated or amplified in cancer, it sets off a chain reaction that helps tumours grow uncontrollably.

The pathway involves a protein called ATF4, and when it’s blocked, it can cause cancer cells to produce too much protein and die.

Published in the journal Nature Cell Biology, the study done on mice points the way towards a new therapeutic approach as inhibitors that can block synthesis of ATF4 already exist.

Cancer
Cancer Ribbon. Pixabay

“What we’ve learned is that we need to go further downstream to block tumour growth in a way that cancer cells can’t easily escape, and our study identifies the target to do just that,” said Constantinos Koumenis, Professor at the University of California.

According to researchers, this finding shows the alternative approach is to target ATF4 itself, since it’s the point where both signal pathways converge, meaning there’s less redundancy built in to allow cancer to survive.

Also Read: Consuming this Bacteria May Cut Risk of Heart Diseases

It also shows that ATF4 turns on the genes MYC needs for growth and also controls the rate at which cells make specific proteins called 4E-BP.

This study also found that when tumours in humans are driven by MYC, ATF4 and its protein partner 4E-BP are also overly expressed, which is further evidence that these findings may point to an approach that could work for humans. (IANS)