Tuesday June 25, 2019

Natural Sugar Supplement “Mannose” Could Help in Fighting Cancer

To test how mannose could also affect cancer treatment, mice were treated with cisplatin and doxorubicin -- two of the most widely used chemotherapy drugs

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cancer
Key gene behind breast cancer identified. Pixabay

Mannose – a nutritional supplement – found naturally in fruits such as cranberries can aid in slowing the growth of tumours and improve cancer treatment, a study has shown.

The findings showed that mannose enhanced the effects of chemotherapy in mice with multiple types of cancer including leukaemia, osteosarcoma, ovarian and bowel cancer. It slowed tumour growth, reduced the size of tumours and even helped increase the lifespan of some mice.

Tumours use more glucose than normal, healthy tissues. However, it is very hard to control the amount of glucose in your body through diet alone. Researchers found that mannose can interfere with glucose to reduce how much sugar cancer cells can use.

“Tumours need a lot of glucose to grow, so limiting the amount they can use should slow cancer progression. The problem is that normal tissues need glucose as well, so we can’t completely remove it from the body.

“In our study, we found a dosage of mannose that could block enough glucose to slow tumour growth in mice, but not so much that normal tissues were affected,” said lead author Kevin Ryan, Professor at the Cancer Research UK Beatson Institute.

Cancer
Cancer Ribbon. Pixabay

“This is early research, but it is hoped that finding this perfect balance means that, in the future, mannose could be given to cancer patients to enhance chemotherapy without damaging their overall health,” he added.

For the study, published in the journal Nature, the team first examined how mice with pancreatic, lung or skin cancer responded when mannose was added to their drinking water and given as an oral treatment. They found that adding the supplement significantly slowed the growth of tumours and did not cause any obvious side effects.

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To test how mannose could also affect cancer treatment, mice were treated with cisplatin and doxorubicin — two of the most widely used chemotherapy drugs.

Some cells responded well to the treatment while others did not. It was also found that the presence of an enzyme that breaks down mannose in cells was a good indicator of how effective treatment was. (IANS)

  • Rajeev Samuel

    Lies – sugar directly is the cause of cancer.

Next Story

GRAIL Announces Significant Progress on Blood Tests to Detect Cancer

Grail's new results are from 2,300 people

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GRAIL, Blood Tests, Detect, Cancer
FILE A patient has her blood drawn at a hospital in Philadelphia to monitor her cancer treatment. VOA

A California company says its experimental blood test was able to detect many types of cancer at an early stage and gave very few false alarms in a study that included people with and without the disease.

Many companies are trying to develop early detection “liquid biopsy” tests that capture bits of DNA that cancer cells shed into blood.

GRAIL, Blood Tests, Detect, Cancer
A California company says its experimental blood test was able to detect many types of cancer at an early stage. VOA

Grail’s new results are from 2,300 people. The test detected 55% of known cancers and gave false alarms for 1%. It also accurately suggested where the cancer may be about 90% of the time.

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The company gave results in news release Friday and will report them Saturday at a conference in Chicago. They have not been published or reviewed by other scientists. (VOA)