Thursday October 24, 2019

Natural Sugar Supplement “Mannose” Could Help in Fighting Cancer

To test how mannose could also affect cancer treatment, mice were treated with cisplatin and doxorubicin -- two of the most widely used chemotherapy drugs

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Key gene behind breast cancer identified. Pixabay

Mannose – a nutritional supplement – found naturally in fruits such as cranberries can aid in slowing the growth of tumours and improve cancer treatment, a study has shown.

The findings showed that mannose enhanced the effects of chemotherapy in mice with multiple types of cancer including leukaemia, osteosarcoma, ovarian and bowel cancer. It slowed tumour growth, reduced the size of tumours and even helped increase the lifespan of some mice.

Tumours use more glucose than normal, healthy tissues. However, it is very hard to control the amount of glucose in your body through diet alone. Researchers found that mannose can interfere with glucose to reduce how much sugar cancer cells can use.

“Tumours need a lot of glucose to grow, so limiting the amount they can use should slow cancer progression. The problem is that normal tissues need glucose as well, so we can’t completely remove it from the body.

“In our study, we found a dosage of mannose that could block enough glucose to slow tumour growth in mice, but not so much that normal tissues were affected,” said lead author Kevin Ryan, Professor at the Cancer Research UK Beatson Institute.

Cancer
Cancer Ribbon. Pixabay

“This is early research, but it is hoped that finding this perfect balance means that, in the future, mannose could be given to cancer patients to enhance chemotherapy without damaging their overall health,” he added.

For the study, published in the journal Nature, the team first examined how mice with pancreatic, lung or skin cancer responded when mannose was added to their drinking water and given as an oral treatment. They found that adding the supplement significantly slowed the growth of tumours and did not cause any obvious side effects.

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To test how mannose could also affect cancer treatment, mice were treated with cisplatin and doxorubicin — two of the most widely used chemotherapy drugs.

Some cells responded well to the treatment while others did not. It was also found that the presence of an enzyme that breaks down mannose in cells was a good indicator of how effective treatment was. (IANS)

  • Rajeev Samuel

    Lies – sugar directly is the cause of cancer.

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Study Says, Men With Breast Cancer Face High Mortality Rates

The study used 11 years of registry data from January 1, 2004, to December 31, 2014, which included 1.8 million female and 16,025 male patients

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Other factors that might influence mortality rates among Men could be lifestyle factors, such as smoking, alcohol consumption, physical inactivity and obesity. Pixabay

Men with breast cancer are more likely to have lower overall survival rates than their female counterparts, a study said.

“The persistent disparity, derived from an analysis of data from the National Cancer Database, suggests a possible distinct cancer biology, less effective treatment or compliance issues, and perhaps unhealthy lifestyles among men may be responsible for the lower overall survival rates,” said the study’s senior author Xiao-Ou Shu from the Vanderbilt University in the US.

The five-year mortality rate for men was 19 per cent higher than women, according to the research published in the journal JAMA Oncology.

The study used 11 years of registry data from January 1, 2004, to December 31, 2014, which included 1.8 million female and 16,025 male patients.

About 85 per cent of male breast cancer is Estrogen receptor (ER)-positive, a proportion that is higher than female breast cancer patients (75 per cent).

“That is a cancer type where patients usually fare better because we have a hormonal treatment.

“We have a lot of treatment options for that type of breast cancer. In theory, men should have better outcomes and have lower mortality as women do if the treatment is equally effective,” Shu said.

According to the researchers, previous studies have shown that men might not be as compliant with hormonal treatments as women.

Men
The five-year mortality rate for Men was 19 per cent higher than women, according to the research published in the journal JAMA Oncology. Pixabay

Other factors that might influence mortality rates among men could be lifestyle factors, such as smoking, alcohol consumption, physical inactivity and obesity.

Clinical characteristics and under treatments were associated with 63 per cent of the sex-related mortality disparity.

ALSO READ: Pancreatic, Colorectal Cancer up 10% in 30 Years, Says Study

“The bottom line is that we need more studies specifically focused on male breast cancer,” Shu added. (IANS)