Wednesday October 16, 2019
Home Lead Story Naturally Occ...

Naturally Occurring Molecule in Immune System Kills Cancer Cells

Researchers have found a naturally occurring molecule and a component of the immune system that could successfully target and kill cancer cells

0
//
human, ageing, development, cancer, study
The researchers found that in most of the tissues examined, ageing and cancer gene expression 'surprisingly' changed in the opposite direction. Pixabay

Researchers have found a naturally occurring molecule and a component of the immune system that could successfully target and kill cancer cells, according to a study.

The study, published in British Journal of Cancer, discovered that beta-galactoside-binding protein, a naturally occurring molecule produced by immune cells can non-specifically target cancer cells, make them undergo cell death and through a stress response pathway make the cancer cells visible to the immune system to prompt an anti-cancer immune response that would secure protection against recurrences.

“By contrast, the anti-tumour property of the molecule is selective and not harmful to normal cells. It is effective against the most aggressive colorectal cancer cells and a wide range of other cancer cells equally unresponsive to current therapies,” said study lead author Professor Livio Mallucci from King’s College London.

“This research presents experimental evidence for a strategy where the targeting of cancer cells and the stimulation of immunity combine to prompt immediate and long-term responses against aggressive cancer,” he said.

According to the researchers, major developments in anti-cancer therapies have taken place over the last decade, but as only a subset of patients respond to treatments, there is a need for further development.

Crucially, there is a need to induce the immune system to ensure long-term protection against the recurrence of cancer.

molecule, immune system, body, cancer, kill cancer cells
Beta-galactoside-binding protein, a naturally occurring molecule produced by immune cells can non-specifically target cancer cells. Pixabay

Current approaches to achieve this involve killing cells by using chemotherapeutics and other agents which could be harmful and have uncertain outcomes, the study said.

ALSO READ: Walk on Rugs And Carpets Made Out Of Plastic Waste

“Translation of the molecule to the clinic could open a new therapeutic opportunity which safely combines direct killing of cancer cells and the stimulation of the immune system against recurrences, a significant step forward in the management of cancer,” he added. (IANS)

Next Story

Newly Tested Medical Device Produces Impressive Results on Body Weight, Fatty Liver and Diabetes Control

For the study, published in the journal EBioMedicine, researchers compared the effects of the Sleeveballoon and traditional bariatric surgery

0
Medical, Device, Body
Sleeveballoon is a device that combines a balloon with a connected sleeve, which covers the initial parts of the small intestine. Pixabay

Researchers have found that a newly tested medical device, called “Sleeveballoon”, mimics the effects of traditional bariatric surgery in rodents and produces impressive results on body weight, fatty liver and diabetes control.

Sleeveballoon is a device that combines a balloon with a connected sleeve, which covers the initial parts of the small intestine. It is inserted into the stomach and bowel during minimally invasive surgery under general anaesthetic.

For the study, published in the journal EBioMedicine, researchers compared the effects of the Sleeveballoon and traditional bariatric surgery on 30 rodents fed with a high-fat diet, achieving very similar results.

Results were also compared to rats, with the new device reducing food intake by 60 per cent and resulting in a 57 per cent reduction in fat mass.

Medical, Device, Body
Sleeveballoon is a device that combines a balloon with a connected sleeve, which covers the initial parts of the small intestine. Pixabay

The effect on diabetes was similarly impressive with blood glucose levels dropping by 65 per cent.

“Gastric bypass surgery is a highly effective treatment of obesity and type 2 diabetes. However, very few eligible patients, only around one per cent, are offered surgery and some also prefer less invasive approaches,” said study’s lead author Geltrude Mingrone, Professor at King’s College London.

During the study, the research team found that the metabolic effects of the Sleeveballoon device are similar to those of the gastric bypass but have distinct advantages over the traditional method.

In both, insulin sensitivity and heart functions improved.

Also Read- PM Modi Stooped Down to Lift Environmental Awareness

“However, while gastric bypass causes a rapid rise in post food blood glucose levels which can cause hypoglycaemia, the Sleeveballoon induces a slowing down of digestion which has a steadying effect on blood sugar levels,” Mingrone said.

“This helps control appetite and hunger, keeping the person fuller for longer and substantially reduces weight,” he added. (IANS)