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Here Comes The New Acne Vaccine

Future studies will address these factors and focus on engineering a non-toxic chemical or targeted vaccine formulation for its human application, the researchers said

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Acne
New vaccine to offer treatment for acne. Pixabay

Do you often suffer from acne? Take heart, a potential vaccine that targets the bacterial toxins may soon be on the anvil, say researchers.

Instead of invading pathogens, the new vaccine would be the first to target bacteria already in human skin.

The researchers demonstrated that antibodies to a toxin secreted from bacteria in acne vulgaris can reduce inflammation in human acne lesions.

“Once validated by a large-scale clinical trial, the potential impact of our findings is huge for the hundreds of millions of individuals suffering from acne vulgaris,” explained lead investigator Chun-Ming Huang, from the University of California-San Diego, US.

An acne vaccination could circumvent potential adverse effects of topical or systemic retinoids and antibiotics, the current treatment options.

acne
Instead of invading pathogens, the new vaccine would be the first to target bacteria already in human skin. Pixabay

They found that Christie-Atkins-Munch-Peterson (CAMP) factor — a toxin secreted from the Propionibacterium acnes (P. acnes) bacteria, can induce inflammatory responses.

In the study, published in the Journal of Investigative Dermatology, the team explored in mice and ex vivo in human skin cells whether they could inhibit inflammation by employing antibodies to neutralise this virulence factor.

Their findings show that the application of monoclonal antibodies to CAMP 2 factor did indeed decrease the inflammatory response.

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“While addressing an unmet medical need and providing an appealing approach, acne immunotherapies that target P. acnes-derived factors have to be cautiously designed to avoid unwanted disturbance of the microbiome that guarantees skin homeostasis,” said Emmanuel Contassot, from the University of Zurich in Switzerland.

Future studies will address these factors and focus on engineering a non-toxic chemical or targeted vaccine formulation for its human application, the researchers said. (IANS)

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Vaccine Alliance GAVI to Invest $178 Million to Create Global Stockpile Ebola Vaccines

Vaccine group announce creation of ebola vaccine stockpile

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Vaccine
There are similar stockpiles for vaccines against yellow fever, meningitis and cholera. Pixabay

The vaccine alliance GAVI announced Thursday it would invest $178 million to create a global stockpile of about 500,000 Ebola vaccines, a decision that health officials say could help prevent future outbreaks from spiraling out of control.

The public-private partnership includes the World Health Organization, UNICEF, the Bill & Melinda Gates Foundation and the World Bank, among others. The funding announcement was made after a meeting of GAVI’s board. GAVI said the investment, which it called an estimate, will be provided between now and 2025.

Since the current outbreak in eastern Congo was identified last August, health officials have immunized more than 255,000 people with a recently licensed vaccine made by Merck. To date there have been nearly 3,200 confirmed Ebola cases, including more than 2,200 deaths, in what has become the second deadliest Ebola outbreak in history.

Dr. Ngozi Okonjo-Iweala, chair of Gavi’s board, called the creation of the Ebola vaccine stockpile a “historic milestone in humanity’s fight against this horrific disease.” GAVI said “a coordinating mechanism” to decide how and when vaccines will be used will be established with partner organizations.

There are similar stockpiles for vaccines against yellow fever, meningitis and cholera. Those limited shots are doled out to developing countries by WHO, UNICEF, the Red Cross and Doctors Without Borders after receiving technical advice from others.

Ebola Vaccine Stockpile
A healthcare worker from the World Health Organization prepares vaccines to give to front line aid workers, in Mbandaka, Congo. VOA

The Ebola vaccine stockpile will be available to all countries, but only developing countries will be able to get vaccines for free in addition to support for the logistical costs of mounting vaccination campaigns.

Jason Nickerson, a humanitarian affairs adviser at Doctors Without Borders, said the new stockpile would change how officials respond to future Ebola outbreaks.

“Knowing how many doses of the vaccine exist in the world, and then being able to get a supply of them to high-risk countries in a very quick way, gives us another tool to respond to these outbreaks,” he said.

Earlier this year, the medical charity publicly called for an independent committee to oversee Ebola vaccination efforts in Congo, saying WHO sometimes used arbitrary criteria to determine who would get immunized. It said the fact that Ebola was continuing to spread despite the large number of people vaccinated was a damning assessment of the response.

Containing this outbreak has been complicated by violence and misunderstandings in a part of Congo that had never reported an Ebola case before.

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Last week, response activities were suspended after attacks killed four Ebola responders, including a member of a vaccination team. Multiple rebel groups operate in eastern Congo and the region has been described as a war zone.

WHO has warned continued attacks on health workers and Ebola clinics could undermine attempts to curb Ebola and prompt a resurgence of the disease. (VOA)