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Here Comes The New Acne Vaccine

Future studies will address these factors and focus on engineering a non-toxic chemical or targeted vaccine formulation for its human application, the researchers said

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Acne
New vaccine to offer treatment for acne. Pixabay

Do you often suffer from acne? Take heart, a potential vaccine that targets the bacterial toxins may soon be on the anvil, say researchers.

Instead of invading pathogens, the new vaccine would be the first to target bacteria already in human skin.

The researchers demonstrated that antibodies to a toxin secreted from bacteria in acne vulgaris can reduce inflammation in human acne lesions.

“Once validated by a large-scale clinical trial, the potential impact of our findings is huge for the hundreds of millions of individuals suffering from acne vulgaris,” explained lead investigator Chun-Ming Huang, from the University of California-San Diego, US.

An acne vaccination could circumvent potential adverse effects of topical or systemic retinoids and antibiotics, the current treatment options.

acne
Instead of invading pathogens, the new vaccine would be the first to target bacteria already in human skin. Pixabay

They found that Christie-Atkins-Munch-Peterson (CAMP) factor — a toxin secreted from the Propionibacterium acnes (P. acnes) bacteria, can induce inflammatory responses.

In the study, published in the Journal of Investigative Dermatology, the team explored in mice and ex vivo in human skin cells whether they could inhibit inflammation by employing antibodies to neutralise this virulence factor.

Their findings show that the application of monoclonal antibodies to CAMP 2 factor did indeed decrease the inflammatory response.

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“While addressing an unmet medical need and providing an appealing approach, acne immunotherapies that target P. acnes-derived factors have to be cautiously designed to avoid unwanted disturbance of the microbiome that guarantees skin homeostasis,” said Emmanuel Contassot, from the University of Zurich in Switzerland.

Future studies will address these factors and focus on engineering a non-toxic chemical or targeted vaccine formulation for its human application, the researchers said. (IANS)

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Vaccine Doubts Spread Across Social Media Like Disease, Should be Taken Down: Vaccine Chief

"We have to think about it as a disease. This is a disease," Berkley said. "This spreads at the speed of light, literally"

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measles epidemic
FILE - A vial of the measles, mumps, and rubella virus (MMR) vaccine is pictured at the International Community Health Services clinic in Seattle, Washington, U.S. VOA

Doubts about vaccines have spread across social media like a disease and false information that “kills people” should be taken down by the companies running digital platforms, the head of global vaccine alliance Gavi said on Tuesday.

Speaking at a U.S.-sponsored event on the sidelines of the World Health Organization’s annual assembly in Geneva, Gavi CEO Seth Berkley said there was a strong scientific consensus about the safety of vaccines.

But social media algorithms favored sensational content over scientific facts, rapidly convincing people who had never seen family members die from preventable illness.

“We have to think about it as a disease. This is a disease,” Berkley said. “This spreads at the speed of light, literally.”

vaccine
“A study says @Autism is out of control — a 78% increase in 10 years. Stop giving monstrous combined vaccinations,” Trump tweeted in 2012. Pixabay

WHO says poor vaccination coverage is causing measles outbreaks globally, with numbers spiking in countries that were previously almost free of the disease, including the United States.

Misinformation about vaccines, which the WHO says save two million lives annually, was not a freedom of speech issue and social media firms need to take it offline, Berkley said. “I remind people that this kills people,” he said.

U.S. Health and Human Services Secretary Alex Azar said complacency, misunderstanding and misinformation were causing vaccination rates to decline globally, with tragic results.

“In my country, social media conspiracy groups confuse well-meaning parents so they hesitate to get the recommended vaccinations,” Azar said.

He rejected any criticism of U.S. President Donald Trump, who repeatedly and erroneously tweeted about links between vaccines and autism in the years before he became president.

“A study says @Autism is out of control — a 78% increase in 10 years. Stop giving monstrous combined vaccinations,” Trump tweeted in 2012.

vaccine
Canada’s Chief Public Health Officer Theresa Tam said health authorities needed to “up our game,” adding that she was working with Twitter, Facebook, Google and other tech companies. Pixabay

Azar said Trump was “extremely firm” in support of vaccination.

“If you had been paying attention in the last month, you would know that the President of the United States, President Trump, was very clear and emphatic: get your shots, get your kids vaccinated, vaccines are safe,” Azar said.

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Canada’s Chief Public Health Officer Theresa Tam said health authorities needed to “up our game,” adding that she was working with Twitter, Facebook, Google and other tech companies.

“You’ve got to get into the trenches … and begin to get engaged much more on a personal and emotional level, because people don’t understand statistics and data. If you do that. (VOA)