Sunday September 22, 2019

New Cancer Treatment To Prevent Hair Loss From Chemotherapy

A novel method discovered recently by a group of researchers, including one of Indian-origin, shows how hair loss from chemotherapy can be prevented during cancer treatment

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Cancer, Chemotherapy, Tiny Bubbles, Research, Treatment
A Caucasian female nurse smiles as she administers chemotherapy through a catheter to an African American male patient in a clinical setting. Wikimedia Commons

A novel method discovered recently by a group of researchers, including one of Indian-origin, shows how hair loss from chemotherapy can be prevented during cancer treatment in patients, arguably one of the most psychologically distressing side effects of modern cancer therapy.

The study published in the journal EMBO Molecular Medicine describes how damage to the hair follicles caused by taxanes, cancer drugs which can cause permanent hair loss, can be prevented.

To do this, the research team has exploited the properties of a newer class of drugs called CDK4/6 inhibitors, which block cell division and are already medically approved as so-called “targeted” cancer therapies.

Cancer, Treatment, Hair, Chemotherapy
Hair loss is a common side effect of chemotherapy, a cancer treatment. I was closely affected cancer even though it was at a young age I am still impacted by it everyday. Hair loss is obviously only one of the many burdens a cancer patient must face. Wikimedia Commons

“Although at first, this seems counterintuitive, we found that CDK4/6 inhibitors can be used temporarily to halt cell division without promoting additional toxic effects in the hair follicle. When we bathed organ-cultured human scalp hair follicles in CDK4/6 inhibitors, the hair follicles were much less susceptible to the damaging effects of taxanes,” study lead author Talveen Purba from the University of Manchester said.

Taxanes are very important anti-cancer drugs commonly used to treat, for example, patients with breast or lung carcinoma and particularly cause anxieties among breast cancer patients for the very distressing and sometimes long-lasting hair loss taxanes can induce.

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“A pivotal part of our study was to first get to grips with how exactly hair follicles responded to taxane chemotherapy, and we found that the specialised dividing cells at the base of the hair follicle that are critical for producing hair itself, and the stem cells from which they arise, are most vulnerable to taxanes.

“Therefore, we must protect these cells most from undesired chemotherapy effects — but so that cancer does not profit from it,” Purba said.

The researchers underscore that more work is desperately needed in this lamentably under-funded field of cancer medicine, where patients have waited for so long to see real breakthroughs in pharmacological hair loss prevention. (IANS)

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Here’s What You Can Do To Undo Damage From Prolonged Sitting

These days prolonged sitting on office chairs for long hours, leads to a sedentary lifestyle our bodies were not designed for

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long sitting hours, prolonged sitting, damage, exercise, treatment
Regular jogging was found to be the best type of exercise. Pixabay

After millions of years of physical evolution, modern humans have a body millions died for — quite literally. However, these days prolonged sitting on office chairs for long hours, leads to a sedentary lifestyle our bodies were not designed for.

IANSlife asks a fitness trainer why sitting in the office for too long is dangerous for your body and how one can undo this damage.

“There are three parts to achieve good health — mental wellness, balanced diet and physical movement. Most of us often struggle with the last — physical movement,” says Shivoham, a fitness trainer and brand ambassador at Avvatar Whey Protein.

“Millennials and Gen-Z are accumulating calories, suffering from weak bones, cardiovascular problems and diabetes more than ever before due to long sitting hours.”

For office-goers, Shivoham recommends a minimum of 20 minutes of daily exercise.

“It doesn’t have to be an elaborate work-out with fancy equipment. One just needs to find out what works best for them.”

long sitting hours, damage, exercise, treatment, prolonged sitting
For office-goers, Shivoham recommends a minimum of 20 minutes of daily exercise. Pixabay

Shivoham’s top tips:

*If you go to work via public transport, try to include a walk to your stop.

*Simple tricks like multiple trips to a water cooler to quench thirst can help you increase your steps and thereby exercising your body.

*Regular stretching and flexing can help one keep their joints and muscles in a healthy condition.

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*Ditch chairs sometimes and sit on a swiss ball as it helps in building a strong core.

*Use a standing bench once in a while to keep up the leg movement.

*Try and sit in an Asian squat position to keep your joints in motion.

The fitness guru urges people to be watchful of their posture while sitting in an office chair. Sitting upright and avoiding a sluggish position is what he advises people who have to sit in the office all day. (IANS)