Thursday, May 13, 2021
Home Life Style Health & Fitness New Approach for Treating Diseases Like Diabetes and Cancer

New Approach for Treating Diseases Like Diabetes and Cancer

Enhanced activation of Vitamin D by protecting beta cells may be a potential new approach for treating diabetes as well as other diseases, including cancer, researchers have suggested.

Enhanced activation of Vitamin D by protecting beta cells may be a potential new approach for treating diabetes as well as other diseases, including cancer, researchers have suggested.

When beta cells — the cells in the pancreas that produce, store and release the hormone insulin — become dysfunctional, the body cannot make insulin to control blood sugar (glucose) and levels of glucose can rise to dangerous and even fatal levels.

The researchers found that Vitamin D in cells and mouse models can be beneficial in treating these damaged beta cells.

They also provided new insights about gene regulation that could be applied to developing treatments for other diseases, including cancer.

“We know that diabetes is a disease caused by inflammation. We identified the Vitamin D receptor as an important modulator of both inflammation and beta cell survival,” said Ronald Evans, from Salk Institute for Biological Studies in California, US.

Combining the new compound with vitamin D allowed certain protective genes to be expressed at much higher levels than they are in diseased cells.
Representational image, pixabay

Using beta cells created from embryonic stem cells, the team was able to identify a compound — iBRD9 — that appeared to enhance the activation of the Vitamin D receptor when it was combined with Vitamin D to improve the survival of beta cells.

In the paper, published in the journal Cell, the team conducted a screening test to look for compounds that improved the survival of beta cells in a dish. They then tested the combination in a mouse model of diabetes and showed that it could bring glucose back to normal levels in the animals.

Combining the new compound with vitamin D allowed certain protective genes to be expressed at much higher levels than they are in diseased cells.

“Activating the vitamin D receptor can trigger the anti-inflammatory function of genes to help cells survive under stressed conditions,” explained Michael Downes, from the institute.

Also Read: A Drug That Can Potentially Cure Hair Loss

The researchers noted that although the new compound did not appear to cause any side effects in the mice, further testing is needed before clinical trials can begin. (IANS)

STAY CONNECTED

19,511FansLike
362FollowersFollow
1,773FollowersFollow

Most Popular

France, UK Concerned About Resurgence In Jihadist Threat

By Jamie Dettmer Nearly 200 jihadists imprisoned in France are due to be released over the next two years and French security officials are pressing French...

What You Need To Know About The Bombings In Gaza By Israeli

BY- JAYA CHOUDHARY Israeli bombings on the Gaza Strip have killed at least 21 people including 16 Palestinians. Among the diseased was a 32-year-old Indian...

Instagram Lets Users Add Pronouns To Their Profiles

Facebook-owned Instagram has announced to let users add up to four pronouns to their profiles, which they can then display publicly or only to...

Queen Elizabeth II Of The UK Presents The Government Agenda

Britain's Queen Elizabeth delivered the official Opening of Parliament speech Tuesday, her first ceremonial appearance since the death of her husband, Prince Philip. The speech,...

How To Recover Nikon Camera Photos

By Hasan Raza Introduction DSLR cameras have long been utilized in the white-collared photography business sector. DSLR’s notoriety in the global marketplace has also increased significantly...

Working On A Cremation Ground During The COVID Period

The shades of dusk are falling -- it is time to exit this space. But people continue to come in with their dead. The...

Healthy India: Encouraging Nursing Education In Schools

The Covid-19 pandemic has not just rattled the lives of millions but has put Indian healthcare machinery under tremendous pressure. From doctors to nurses to...

International Nurses Day: History And Significance

By- Khushi Bisht The International Nurses Day is observed on May 12th every year worldwide to honor the contributions of nurses. The International Council of...

Recent Comments