Wednesday January 29, 2020

Researchers Discover New Drug Which may Protect Against Memory Loss, Nerve Damage and Other Symptoms of Alzheimer’s Disease

BPN14770, under development by Tetra Therapeutics, could help activate these mechanisms that support nerve health and prevent dementia

0
//
Drug, Memory Loss, Nerve Damage
Preclinical research published in the Journal of Pharmacology and Experimental Therapeutics found that the drug -- called BPN14770 -- deters the effects of amyloid beta, a hallmark protein of Alzheimer's that is toxic to nerve cells. Pixabay

Researchers have discovered a new drug which may protect against memory loss, nerve damage and other symptoms of Alzheimer’s disease.

Preclinical research published in the Journal of Pharmacology and Experimental Therapeutics found that the drug — called BPN14770 — deters the effects of amyloid beta, a hallmark protein of Alzheimer’s that is toxic to nerve cells.

BPN14770, under development by Tetra Therapeutics, could help activate these mechanisms that support nerve health and prevent dementia, even with the progression of Alzheimer’s.

“Such observations imply that Alzheimer’s pathology can be tolerated by the brain to some extent due to compensatory mechanisms operating at the cellular and synaptic levels,” said study researcher Ying Xu, Associate Professor at University at Buffalo.

Drug, Memory Loss, Nerve Damage
Researchers have discovered a new drug which may protect against memory loss, nerve damage and other symptoms of Alzheimer’s disease. Pixabay

“Our new research suggests that BPN14770 may be capable of activating multiple biological mechanisms that protect the brain from memory deficits, neuronal damage and biochemical impairments,” Xu added.

The research conducted in mice, discovered that BPN14770 inhibits the activity of phosphodiesterase?4D (PDE4D), an enzyme that plays a key role in memory formation, learning, neuroinflammation and traumatic brain injury.

PDE4D lowers cyclic adenosine monophosphate (cAMP) — a messenger molecule that signals physiological changes such as cell division, change, migration and death — in the body, leading to physical alterations in the brain.

cAMP has numerous beneficial functions, including improved memory. By inhibiting PDE4D, BPN14770 increases cAMP signalling in the brain, which ultimately protects against the toxic effects of amyloid beta.

Also Read- Tata Power to Launch Customer Services on Microsoft Kaizala

“The role of PDE4D in modulating brain pathways involved in memory formation and cognition, and the ability of our PDE4D inhibitor to selectively enhance this process, has been well studied,” said Mark E. Gurney from Tetra Therapeutics.

“We are very excited by our colleagues’ findings, which now suggest a second protective mechanism of action for BPN14770 against the progressive neurological damage associated with Alzheimer’s disease,” Gurney said.

“Developing effective drugs for memory deficits associated with Alzheimer’s disease has been challenging,” said M. O’Donnell, Professor at University at Buffalo.

“BPN14770 works by a novel mechanism to increase cyclic AMP signalling in the brain, which has been shown to improve memory. The collaborative project has led to clinical trials that will begin to test its effectiveness,” O’Donnell said. (IANS)

Next Story

Cannabis Usage Common in Adults with Pain Disorders: Study

Cannabis use disorder more common in adults with pain

0
Cannabis adults
Researchers have found that non-medical use of cannabis including frequent or problematic use is much more common in adults who have pain than in others. Pixabay

Researchers have found that non-medical use of cannabis including frequent or problematic use is much more common in adults who have pain than in others.

Since 1996, 34 US states have passed medical marijuana laws and 11 states have legalised recreational cannabis use.

Studies indicate that heavy cannabis use increases the risk of vehicle accidents, respiratory and psychiatric symptoms, and cannabis use disorder.

“Despite this evidence, many people view cannabis use as harmless, and non-medical use of cannabis on a daily or near-daily basis has increased,” said study lead author Deborah Hasin from Columbia University Vagelos College of Physicians and Surgeons in the US.

“In our study, we hoped to identify factors–such as pain–that may increase the risk of cannabis use disorder,” Hasin added.

Cannabis adults
66 per cent of adults now view marijuana as beneficial for pain management, the researchers said. Pixabay

For the findings, published in the American Journal of Psychiatry, research team analysed data on marijuana use from the National Epidemiologic Surveys on Alcohol and Related Conditions in 2001-2002 and 2012-2013.

The researchers compared non-medical cannabis use patterns in adults with and without pain (approximately 20 per cent of participants in both surveys had moderate to severe pain).

Overall, non-medical marijuana use increased from about four per cent in 2002 to 9.5 per cent in 2013.

In addition, in the most recent survey, those with pain were significantly more likely to engage in frequent non-medical cannabis use than those without pain (5.0 per cent vs. 3.5 per cent).

According to the researchers, the risk of cannabis use disorder was also significantly higher in those with pain (4.2 per cent vs. 2.7 per cent).

Also Read- BP Problems in Youth May Lead to Heart Diseases

Although meta-analyses of cannabis for treating pain show only mixed efficacy, particularly for plant marijuana, 66 per cent of adults now view marijuana as beneficial for pain management, the researchers said.

“Given that about 20 of the adult population experienced moderate to severe pain, this puts a large group of US adults at risk for frequent non-medical use and cannabis use disorder,” Hasin said. (IANS)