Tuesday January 21, 2020

New Finding! Blood Test That Could Detect Risk Of Pre-Term Delivery

"Our goal is to develop prognostic markers for patients to help make predictions and offer highly personalised care to woman from early stages of pregnancy,"

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pregnancy
Mothers with history of pre-term deliveries face higher risks. But predicting spontaneous pre-term birth is challenging, particularly in the case of first-time mothers, the team said. Pixabay

Researchers are working on a blood test that could be able to detect risk of spontaneous pre-term delivery.
According to a study, published in the American Journal of Obstetrics & Gynaecology, five micro particle proteins found in first-trimester blood samples may give clues about the risk of spontaneous pre-term birth.

“Our goal is to develop prognostic markers for patients to help make predictions and offer highly personalised care to woman from early stages of pregnancy,” said co-author Thomas McElrath from the Brigham and Women’s Hospital in the US.

blood
Mothers with history of pre-term deliveries face higher risks. But predicting spontaneous pre-term birth is challenging, particularly in the case of first-time mothers, the team said. Pixabay

According to researchers, nearly 10 per cent births are taking place before 37-week gestation against the normal 40 weeks. Pre-term birth can result in several conditions, including pre-term labour, early rupture of the placental membrane or preeclampsia.

Mothers with history of pre-term deliveries face higher risks. But predicting spontaneous pre-term birth is challenging, particularly in the case of first-time mothers, the team said.

For the study, researchers studied blood samples, collected toward the end of the first trimester of pregnancy, from three established biobanks.

pregnancy
Mothers with history of pre-term deliveries face higher risks. But predicting spontaneous pre-term birth is challenging, particularly in the case of first-time mothers, the team said. Pixabay

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The team compared samples from 87 women who delivered at or before 35 weeks with samples from 174 women who delivered at term and were of the same age and at the same week of pregnancy at the time giving blood.

They analysed multiple circulating micro particles associated proteins and found that a subset of these proteins could help predict risks, both for the first-time mothers as well as those who had previously given birth. (IANS)

Next Story

Gene Expression Signature in Blood May Predict Onset of Tuberculosis

This blood test may predict onset of tuberculosis

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Blood Test
Gene expression signatures in blood could be used to predict tuberculosis at a very early stage. PIxabay

Researchers, including one of Indian-origin, have revealed a blood test could predict the onset of tuberculosis three to six months before people become unwell, a finding which could help better target antibiotics and save countless lives. This test is a must for a healthy lifestyle.

For the findings, published in the journal Lancet Respiratory Medicine, researchers at University College London sought to identify which, if any, gene expression signatures in blood could be used to predict the disease at a very early stage and before symptoms

Gene expression signatures are single or combined measurements of levels of specific gene products and are being tested in a range of diseases to aid diagnosis, prognosis or prediction of the response to treatment.

Some are already being used to support the management of cancers, but none have reached the clinic in infectious diseases, such as tuberculosis (TB).

“Our findings establish the gene signatures in blood which show most promise for identifying people who are at risk of disease,” said study author Mahdad Noursadeghi, Professor at University College London.

Blood Test
The emergence of gene expression signature blood tests, which can aid diagnosis and early treatment, provides real hope for the management of infectious diseases. Pixabay

“Future development of a blood test based on these findings could make an important contribution to efforts to reduce the impact and spread of this deadly infection,” Noursadeghi added.

For this study, researchers initially conducted a systematic review of published gene signatures found to be present in blood samples from people with TB, compared to healthy individuals.

From this, 17 candidate gene expression signatures for TB were identified, and tested in more than 1,100 blood samples in published data sets from South Africa, Ethiopia, The Gambia, and the UK. Scientists analysed samples from people who had no TB symptoms at the time they gave blood. Those people were then followed up to identify which participants developed TB in the subsequent months.

Researchers found that eight of these signatures, including measurement of expression of a single gene, could predict the diagnosis of TB within three to six months, which falls within the accuracy required by the World Health Organisation (WHO) for new diagnostic tests.

This accuracy was achieved, by revealing the patients’ immune responses to bacteria before the symptoms of the disease develop. “The emergence of gene expression signature tests, which can aid diagnosis and early treatment, provides real hope for the management of infectious diseases,” said Indian-origin researcher and the study’s lead author Rishi Gupta.

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“In this study we identify multiple signatures to identify the onset of tuberculosis, which is extremely encouraging, potentially providing multiple targets for early detection,” Gupta added.

Further development of these tests could help identify people who will benefit most from preventative antibiotic treatment, in order to reduce the occurrence of tuberculosis, the researchers said. (IANS)