Thursday February 21, 2019

New Link Found Between Alcohol, Genes And Heart Failure

The team found that the faulty titin gene may also play a role in the condition

0
//
Hangovers might last longer than you think
Hangovers might last longer than you think. Pixabay

Even moderate level of alcohol consumption may worsen the condition of heart failure patients with a faulty versions of a gene called titin, new research has found.

Titin is crucial for maintaining the elasticity of the heart muscle. But faulty version of the gene may cause dilated cardiomyopathy (DCM)– a type of heart failure where the left ventricle becomes weak causing lessening the ability to pump blood.

“Our research strongly suggests alcohol and genetics are interacting — and genetic predisposition and alcohol consumption can act together to lead to heart failure,” said study co-author James Ware from the National Heart and Lung Institute at Imperial College London.

For the first part of the study, the team analysed 141 patients with a type of heart failure called alcoholic cardiomyopathy (ACM) — a type of heart failure due to long term alcohol abuse which may trigger because of drinking more than 70 units a week (roughly seven bottles of wine) for five years or more.

Representational image.
Representational image. Pixabay

The team found that the faulty titin gene may also play a role in the condition.

The results, published in Journal of the American College of Cardiology, showed that 13.5 per cent of ACM patients carried the mutation — much higher than the proportion of people who carry them in the general population.

Ware explained that the condition is not simply the result of alcohol poisoning, but arises from a genetic predisposition and thus can put other family members at risk as well.

He added that relatives of patients with ACM should receive assessment and heart scans to see if they unknowingly carry the faulty gene.

Also Read: Alcoholic Beverages Aren’t That Good For You As You May Have Thought

In the second part, the team analysed 716 patients with dilated cardiomyopathy – a condition that causes the heart muscle to become stretched and thin.

The team found that in patients whose DCM was caused by the faulty titin gene, even moderately increased alcohol intake (defined as drinking above the weekly recommended limit of 14 units), affected the heart’s pumping power.

“Alcohol and the heart have a complicated relationship. While moderate levels may have benefits for heart health, too much can cause serious cardiac problems. This research suggests that in people with titin-related heart failure, alcohol may worsen the condition,” explained study co-author, Paul Barton from the National Heart and Lung Institute at Imperial. (IANS)

Next Story

Early Onset of Drinking May Lead to Alcohol Dependence, Says Study

To prevent or delay early onset of drinking, more should be known about the modifiable circumstances that enable these behaviours

0
drinking
In the experiments, rats were trained to drink alcohol in a way that mimics human binge-drinking behaviour. Pixabay

Early onset of drinking and intoxication may lead to heavy drinking and alcohol dependence among people, warn researchers from the Pacific Institute for Research and Evaluation in the US.

Researchers concluded this in a study on the correlation between early age (less than 15 years) and contexts of first intoxication such as one’s own home, friends’ homes or outdoor settings, and the problems that arise in these contexts.

For their research, the team studied 405 adolescent (aged 15-18 years) drinkers.

According to the findings, published in the journal Substance Use & Misuse, about one-third of adolescent drinkers experienced their first intoxication by the age of 15, about one-third experienced it after 15, and about one-third had consumed alcohol but never to the stage of intoxication.

A new drug can reduce Alcohol addiction in teenagers
Early age drinking linked to alcohol dependence: Study. Pixabay

In addition, drinkers reported drinking most frequently at homes, followed by outdoor settings, and then in restaurants, bars or nightclubs.

The early age of first intoxication was found to be strongly linked to drinking in outdoor settings, but not to drinking at home.

Also Read- 5G, Foldable Smartphones to Dominate Mobile World Congress 2019

The results of the study emphasise importance of contexts in early alcohol initiation and the resulting problems to inform development of preventive interventions specific to contexts, said Lipperman-Kreda, a researcher from the varsity.

To prevent or delay early onset of drinking, more should be known about the modifiable circumstances that enable these behaviours, the study suggested. (IANS)