Monday April 22, 2019

New Link Found Between Alcohol, Genes And Heart Failure

The team found that the faulty titin gene may also play a role in the condition

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Hangovers might last longer than you think
Hangovers might last longer than you think. Pixabay

Even moderate level of alcohol consumption may worsen the condition of heart failure patients with a faulty versions of a gene called titin, new research has found.

Titin is crucial for maintaining the elasticity of the heart muscle. But faulty version of the gene may cause dilated cardiomyopathy (DCM)– a type of heart failure where the left ventricle becomes weak causing lessening the ability to pump blood.

“Our research strongly suggests alcohol and genetics are interacting — and genetic predisposition and alcohol consumption can act together to lead to heart failure,” said study co-author James Ware from the National Heart and Lung Institute at Imperial College London.

For the first part of the study, the team analysed 141 patients with a type of heart failure called alcoholic cardiomyopathy (ACM) — a type of heart failure due to long term alcohol abuse which may trigger because of drinking more than 70 units a week (roughly seven bottles of wine) for five years or more.

Representational image.
Representational image. Pixabay

The team found that the faulty titin gene may also play a role in the condition.

The results, published in Journal of the American College of Cardiology, showed that 13.5 per cent of ACM patients carried the mutation — much higher than the proportion of people who carry them in the general population.

Ware explained that the condition is not simply the result of alcohol poisoning, but arises from a genetic predisposition and thus can put other family members at risk as well.

He added that relatives of patients with ACM should receive assessment and heart scans to see if they unknowingly carry the faulty gene.

Also Read: Alcoholic Beverages Aren’t That Good For You As You May Have Thought

In the second part, the team analysed 716 patients with dilated cardiomyopathy – a condition that causes the heart muscle to become stretched and thin.

The team found that in patients whose DCM was caused by the faulty titin gene, even moderately increased alcohol intake (defined as drinking above the weekly recommended limit of 14 units), affected the heart’s pumping power.

“Alcohol and the heart have a complicated relationship. While moderate levels may have benefits for heart health, too much can cause serious cardiac problems. This research suggests that in people with titin-related heart failure, alcohol may worsen the condition,” explained study co-author, Paul Barton from the National Heart and Lung Institute at Imperial. (IANS)

Next Story

Research Revels, Consuming Alcohol Even Once A Day Raises Risk of Heart Stroke

"There are no protective effects of moderate alcohol intake against stroke. Even moderate alcohol consumption increases the chances of having a stroke," said Zhengming Chen, Professor at the University of Oxford in the UK. 

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The researchers stressed that stronger policies are required adding that the alcohol industry, which is thriving, should be regulated in a similar way to the tobacco industry. Pixbay

While it is known that excess drinking is harmful for health, a new study suggests that even consuming one or two alcoholic drinks a day can raise stroke risks, challenging previous claims.

The study, published in The Lancet journal, showed that alcohol directly increases blood pressure and the chances of having a stroke.

 

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According to the World Health Organization, stroke is the second leading cause of death and the third leading cause of disability globally and claims 6.2 million lives each year. Pixabay

“Stroke is a major cause of death and disability. This study has shown that stroke rates are increased by alcohol. This should help inform personal choices and public health strategies,” said Liming Li, Professor at the Peking University in China.

“There are no protective effects of moderate alcohol intake against stroke. Even moderate alcohol consumption increases the chances of having a stroke,” said Zhengming Chen, Professor at the University of Oxford in the UK.

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The study, published in The Lancet journal, showed that alcohol directly increases blood pressure and the chances of having a stroke. 
Pixabay

According to the World Health Organization, stroke is the second leading cause of death and the third leading cause of disability globally and claims 6.2 million lives each year.

Also Read: How Maz Jobrani Uses Comedy to Bridge Culture Divide?

The researchers stressed that stronger policies are required adding that the alcohol industry, which is thriving, should be regulated in a similar way to the tobacco industry.

For the study, the researchers involved 500,000 Chinese men and women for a period of 10 years. (IANS)