Sunday January 26, 2020

New Link Found Between Alcohol, Genes And Heart Failure

The team found that the faulty titin gene may also play a role in the condition

0
//
Hangovers might last longer than you think
Hangovers might last longer than you think. Pixabay

Even moderate level of alcohol consumption may worsen the condition of heart failure patients with a faulty versions of a gene called titin, new research has found.

Titin is crucial for maintaining the elasticity of the heart muscle. But faulty version of the gene may cause dilated cardiomyopathy (DCM)– a type of heart failure where the left ventricle becomes weak causing lessening the ability to pump blood.

“Our research strongly suggests alcohol and genetics are interacting — and genetic predisposition and alcohol consumption can act together to lead to heart failure,” said study co-author James Ware from the National Heart and Lung Institute at Imperial College London.

For the first part of the study, the team analysed 141 patients with a type of heart failure called alcoholic cardiomyopathy (ACM) — a type of heart failure due to long term alcohol abuse which may trigger because of drinking more than 70 units a week (roughly seven bottles of wine) for five years or more.

Representational image.
Representational image. Pixabay

The team found that the faulty titin gene may also play a role in the condition.

The results, published in Journal of the American College of Cardiology, showed that 13.5 per cent of ACM patients carried the mutation — much higher than the proportion of people who carry them in the general population.

Ware explained that the condition is not simply the result of alcohol poisoning, but arises from a genetic predisposition and thus can put other family members at risk as well.

He added that relatives of patients with ACM should receive assessment and heart scans to see if they unknowingly carry the faulty gene.

Also Read: Alcoholic Beverages Aren’t That Good For You As You May Have Thought

In the second part, the team analysed 716 patients with dilated cardiomyopathy – a condition that causes the heart muscle to become stretched and thin.

The team found that in patients whose DCM was caused by the faulty titin gene, even moderately increased alcohol intake (defined as drinking above the weekly recommended limit of 14 units), affected the heart’s pumping power.

“Alcohol and the heart have a complicated relationship. While moderate levels may have benefits for heart health, too much can cause serious cardiac problems. This research suggests that in people with titin-related heart failure, alcohol may worsen the condition,” explained study co-author, Paul Barton from the National Heart and Lung Institute at Imperial. (IANS)

Next Story

Here’s Why Light Alcohol Consumption Might Also Increase Cancer Risk

The researchers found an almost linear association between cancer risk and alcohol consumption

0
Alcohol
In a study published in the journal Cancer, the overall cancer risk appeared to be the lowest at zero alcohol consumption. Pixabay

If you thought one-two drinks a day would not do any harm, think again. Researchers in Japan have found that even light alcohol consumption might increase the cancer risk.

In the study published in the journal Cancer, the overall cancer risk appeared to be the lowest at zero alcohol consumption. The elevated risk appeared to be explained by alcohol-related cancer risk across relatively common sites, including the colorectum, stomach, breast, prostate and esophagus.

“In Japan, the primary cause of death is cancer,” said one of the researchers Masayoshi Zaitsu from The University of Tokyo. “Given the current burden of overall cancer incidence, we should further encourage promoting public education about alcohol-related cancer risk,” Zaitsu said. The team examined clinical data on 63,232 patients with cancer and 63,232 controls matched for sex, age, hospital admission date, and admitting hospital. The data was gathered from 33 general hospitals in Japan.

All participants reported their average daily amount of standardised alcohol units and the duration of drinking. One standardised drink containing 23 grams of ethanol was equivalent to one 180-ml cup of Japanese sake, one 500-ml bottle of beer, one 180-ml glass of wine, or one 60-ml cup of whiskey.

Drink, Alcohol, Cup, Whiskey, The Drink
If you thought one-two drinks a day would not do any harm, think again. Researchers in Japan have found that even light alcohol consumption might increase the cancer risk. Pixabay

The researchers found an almost linear association between cancer risk and alcohol consumption. A light level of drinking at 10-drink-year point, for example, one drink per day for 10 years or two drinks per day for five years would increase cancer risk by five per cent, the findings showed.

ALSO READ: Smartphone Giant Vivo To Introduce iQOO Premium Phone in India Next Month

Those who drank two or fewer drinks a day had an elevated cancer risk regardless of how long they had consumed alcohol. Also, analyses classified by sex, drinking/smoking behaviours and occupational class mostly showed the same patterns. (IANS)