Monday, July 6, 2020
Home Life Style Health & Fitness Researchers Find a New Mechanism to Prevent Obesity

Researchers Find a New Mechanism to Prevent Obesity

New mechanism may safely prevent, reverse obesity

Obesity, a global epidemic, is a known contributor to several cancers, including breast, colon, and pancreatic and in major breakthrough, researchers have discovered that a receptor found in almost all cells, called AHR, and known primarily to combat exposures to environmental chemicals, also plays a big role in the body’s metabolism.

Stopping the obesity epidemic could be a critical aid in preventing and treating numerous cancers and study, published in the journal International Journal of Obesity have found a critical target in this cause.

“We carried out experiments showing that when a drug named NF and known to block the AHR, was added to a high-fat diet, mice did not become any fatter than mice on a low-fat control diet,” said study researcher Craig Tomlinson from Dartmouth-Hitchcock Norris Cotton Cancer Centre in the US.

“Mice on the high-fat diet with no NF became very obese within the same time span. No ill effects were observed from the drug,” Tomlinson added. According to the study, the research team then asked whether blocking the AHR with NF could not only prevent obesity but reverse it.

Obesity
Obesity is a known contributor to several cancers, including breast, colon, and pancreatic. Pixabay

“In these experiments, we allowed the mice to become obese on a high-fat diet, and then half the mice were switched to the high-fat diet containing the AHR blocker NF,” Tomlinson said.

Over the next few weeks, the mice switched to the high-fat diet containing NF dropped to the same body weight as those mice on the low-fat diet.

The remaining mice on the high-fat diet became obese. No ill effects were observed, the researchers said. The research team investigated the mechanisms behind how the AHR, when blocked by NF, prevented and reversed obesity.

Using previous knowledge that the AHR regulates key genes in fat metabolism, the team discovered that in liver cells and in fat cells, the AHR, when blocked by NF, fails to induce several key genes required for fat storage and synthesis.

They concluded that the prevention and reversal of obesity from blocking the activity of the AHR is due to key genes regulated by the AHR that are involved in fat metabolism.

“Few to no studies have shown that obesity can be reversed by a drug treatment; it is even rarer to know the underlying cellular mechanism,” Tomlinson noted.

Also Read- Instagram Starts Testing its Direct Messaging Feature on its Desktop Site

The research team has begun investigating several key questions, including those around the dietary compounds in the food we eat that activate the AHR to cause weight gain , and the role that gut bacterial play regarding the AHR. Most importantly, they have initiated a clinical trial to determine whether the AHR may serve as a therapeutic target to reduce obesity in humans. (IANS)

STAY CONNECTED

18,998FansLike
362FollowersFollow
1,780FollowersFollow

Most Popular

Infant Sleep issues Linked To Mental Health Problems in Adults

Researchers have found that sleeping problems in early childhood may be linked to the development of certain mental health disorders in adolescence. The study, published...

10,000 Bed Sardar Patel Covid-19 Centre To set up at Delhi

The 10,000-bed Sardar Patel Covid-19 Care Centre and Hospital, inaugurated here on Sunday by Delhi Lieutenant-Governor Anil Baijal, which will serve as a major...

UP Government to Set World Record in Tree Plantation Drive

The Yogi Adityanath government is all set to set a new world record by planting 25 crore trees on Sunday in a massive plantation...

Queer Representation in Bollywood

Soon, Akshay Kumar will be seen essaying the role of a transgender in "Laxmmi Bomb". Sonam Kapoor has explored the complexities of being a...

WHO Stops Hydroxychloroquine, HIV drugs in Covid-19 trials

The World Health Organization (WHO) said on Saturday that it was discontinuing its trials of the malaria drug hydroxychloroquine and combination HIV drug lopinavir/ritonavir...

Coronavirus Cases Sets Record Daily Jump : WHO

The world saw a record 24-hour increase in the number of coronavirus cases Saturday — 212,326, the World Health Organization (WHO) reported. The United States,...

India Confident of Covid Vaccine, Trial Stage Marks ‘Beginning of the End’

As India races to bring a vaccine for Covid-19 by mid August, the government on Sunday said that it is entering the human trial...

Malaika Arora Shares Home Remedy to Boost Immunity

Dancing diva Malaika Arora has shared a "make in India" home remedy to boost immunity. Some people have started stepping out for work, but relaxed...

Recent Comments