Monday December 9, 2019

New Tool Reveals Insecticide-Treated Bed Net Use Spotty, Lifting Malaria Risk

More than 400,000 people die from malaria each year, making it one of the world’s deadliest preventable diseases

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Researchers in Uganda demonstrate the design of the SmartNet technology. SmartNets use conductive fabric to detect when they are folded up or in use. (Courtesy - Paul Krezanoski). VOA

A new tool for monitoring bed net use reveals that people don’t use their bed nets consistently, which could contribute to the recent slowdown in progress in the fight against malaria.

More than 400,000 people die from malaria each year, making it one of the world’s deadliest preventable diseases. Insecticide-treated bed nets are widely used to prevent bites from malaria-carrying mosquitoes, and are responsible for preventing an estimated 450 million malaria cases in Africa between 2000 and 2015.

However, the World Health Organization reports that efforts to stop the spread of malaria have stalled since 2015. Bed nets may be losing their effectiveness as mosquitoes adapt their behavior to bite earlier in the day, when people aren’t protected by their bed nets, and gain resistance to common insecticides.

Dr. Paul Krezanoski, lead author of a study published in The American Journal of Tropical Medicine and Hygiene, explored another possibility. He and his research team wanted to know if people actually use their bed nets as recommended – unfurling them around dusk and packing them away after dawn.

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Malaria prevention insecticide treated bed nets. Wikimedia Commons

However, tracking bed net use can be a challenge. Existing methods are imprecise, like self-reporting, or invasive, like surprise night-time visits to check that nets are in use.

Krezanoski worked with scientists from the Consortium for Affordable Medical Technologies (CAMTech) innovation center in Mbarara, Uganda, to develop a better way to monitor bed net usage. They invented an enhanced bed net called SmartNet, which uses strips of conductive fabric to detect when the net is spread out in use versus folded up and put away.

The researchers recruited 10 families in western Uganda to use the SmartNets as they would any normal bed net for six weeks. The nets recorded whether or not they were in use at 15-minute intervals. Bed net use varied widely from family to family and night to night, and users often neglected to deploy the nets during the hours that mosquitoes were most active. Nets were in use continuously between 6:00 PM and 9:00 AM in less than 10% of cases. Occasionally, they weren’t used at all.

“You would think that if people are being monitored they would use their bed net in a pristine way,” said Krezanoski. “But that’s not what happened, and what that tells me is that there’s probably a whole lot more variation in bed net use than we realize.”

Not only was there variety in when the families unfurled their nets in the evening and put them away in the morning, some families also recorded night-time interruptions. While the reasons for these interruptions aren’t known, the researchers assumed that many were due to childcare duties or using the bathroom.

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More than 400,000 people die from malaria each year, making it one of the world’s deadliest preventable diseases. Pixabay

“I think it’s quite innovative,” said Kate Zinszer, an infectious disease epidemiologist at the Université de Montréal who wasn’t involved in the study. “There is a substantial investment in bed nets and really understanding what actual usage is is a huge gap in current efforts.”

A lingering uncertainty in the study is how being monitored affected the users’ behavior. Krezanoski believes that study subjects would be more careful to use their nets properly than an average person, but others thought they might be less likely. Zawadi Mageni Mboma, a malaria researcher at Ifakara Health Institute who was not involved in the study, said in an email that people’s dislike of being watched or tracked could deter them from using the SmartNets, especially in long-term trials.

Despite that, she added, “Insecticide-treated nets are at the core of malaria intervention. So any information that could further improve the effectiveness is a huge deal for malaria control and elimination.”

ALSO READ: Children Under Five at Higher Risk of Ebola Outbreak; Represent One-third of Current Total Cases

The results of the study may also help researchers disentangle the effects of human behavior from other factors, like mosquitoes’ increased insecticide resistance. Ultimately, Krezanoski hopes to be able to show a correlation between how long young children use bed nets and their risk of getting malaria. Krezanoski’s next steps are already underway. He’s part of a research team that will track SmartNet usage, malaria infections and mosquito behavior in 80 households in Uganda.

“I think that will help the international malaria community define exactly how much investment we need to give to bed nets as a whole and also in terms of human behaviors around bed nets, and help us figure out the best ways to reduce malaria going into the future,” he said. (VOA)

Next Story

Soups Can Help You Fight Malaria: Study

Consuming home-made soups can save you from malaria, suggests a new study

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Soups fight malaria
Consuming soups can save you from malaria. Pixabay

“Malaria kills more than 400,000 people per year and infects more than 200 million, yet resistance to our frontline drugs continues to emerge,” said study lead researcher Jake Baum, Professor at Imperial College London, in UK.

“We may have to look beyond the chemistry shelf for new drugs, and natural remedies shouldn’t be off our watch list,” Baum added.

For the study, published in the journal Archives of Disease in Childhood, researchers from Imperial College London with school children test their family soup broths for activity against the malaria parasite.

Several of the soup broths, collected from traditional family recipes that originated around the world, showed activity against the malaria parasite Plasmodium falciparum, either by curbing its growth or preventing it from maturing.

The soup recipes had been passed down through the generations for the treatment of fever.

Five of the broths were able to curb growth of the parasite in its disease-causing stage by more than 50 percent.

In two of these, the inhibitory activity was comparable with that of a leading anti-malarial drug, dihydroartemisinin.

Four other broths were more than 50 percent effective at blocking the ability of the parasites to mature to a form that infects mosquitoes, potentially blocking the process of transmission.

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Prevent malaria with healthy soups. Pixabay

Dihydroarteminisin contains artemisinin, which was isolated from a traditional Chinese herbal medicine.

According to the researchers, the study was carried out by students at Eden Primary School in North London.

The pupils brought in samples of homemade clear soup broths from family recipes from across Europe, North Africa, and the Middle East.

Filtered extracts of the broths were then tested against two stages of the parasite: when it can infect mosquitoes, and when it can cause the disease in humans.

The recipes for each of the broths varied.

They were vegetarian, chicken, or beef based, with no particular ingredient common to those with the strongest anti-malarial activity.

The active ingredients in the broths studied are yet to be identified and tested, the study said.

To move forwards, the active ingredients would need to be isolated, before tests of toxicology and effectiveness, first in human cells and later preclinical trials.

Also Read- Here’s Why Too Much Ultra-Processed Food Can Deteriorate your Heart Health

The researchers behind the study hope that they may discover new anti-malarial compounds in a similar way from the work looking at soup.

“It’s really interesting to find potential routes for future drug development in something like your grandmother’s soup,” Baum added. (IANS)