Sunday December 15, 2019

Novel Approach to Treat Cancer Cells

"We have shown that we can image 'activated platelets' to detect tumours with clinically available imaging technologies such as ultrasound and PET/CT," said Karlheinz Peter, Professor at the varsity

0
//
Cancer word on newspaper
Cancer. Pixabay

Researchers could provide a novel approach to targeting and destroying difficult-to-treat cancer cells, providing new therapeutic options for a broad range of cancers, finds a new study.

Early detection of cancer is crucial for successful therapy. However, some cancer types do not have specific cancer surface markers that can be used to detect them and even the same cancer type can exhibit different properties in different patients.

The latest finding, which was discovered while studying activated platelets in the setting of heart disease, may now prove useful for delivering targeted treatment to cancer cells without major side effects.

Platelets are small blood cells that promote blood clotting and prevent us from bleeding when we are injured.

Platelets and more specifically, “activated platelets”, accumulate in the area surrounding a wide range of tumour types.

Cancer
Cancer Ribbon. Pixabay

Based on this observation, a team at the Baker Heart and Diabetes Institute in Australia has now developed a new imaging and platelet-targeting chemotherapy agent for the early detection and treatment of cancers.

In addition, this approach provides the means to deliver high concentrations of chemotherapy specifically to tumour cells whilst minimising side effects and preventing tumour growth, said the study published in the journal Theranostics.

Also Read- Study Reveals Shape and Structure of The Milky Way Galaxy

“We have shown that we can image ‘activated platelets’ to detect tumours with clinically available imaging technologies such as ultrasound and PET/CT,” said Karlheinz Peter, Professor at the varsity. (IANS)

Next Story

Saliva Test can Detect Oropharyngeal Cancer

Saliva test can detect mouth, throat cancer early

0
cancer
Saliva test shows promise for earlier and easier detection of mouth and throat cancer. Pixabay

A non-invasive saliva test can detect human papilloma virus-16 — the strain associated with oropharyngeal cancer (OPC) — showing promise for earlier and easier detection of mouth and throat cancer, report researchers.

The novel technique detected OPC in whole saliva in 40 per cent of patients tested and 80 per cent of confirmed OPC patients.

OPC has an approximate incidence of 115,000 cases per year worldwide and is one of the fastest-rising cancers owing to increasing HPV-related incidence, especially in younger patients.

“It is paramount that surveillance methods are developed to improve early detection and outcomes,” said co-lead investigator Tony Jun Huang from Duke University in the US.

Cancers that occur in the back of the mouth and upper throat are often not diagnosed until they become advanced, partly because their location makes them difficult to see during routine clinical exams.

saliva test cancer
Cancers that occur in the back of the mouth and upper throat are often not diagnosed until they become advanced. Pixabay

“The successful detection of HPV from salivary exosomes isolated by our acoustofluidic platform offers distinct advantages, including early detection, risk assessment and screening,” added Dr Huang in a paper published in The Journal of Molecular Diagnostics.

This technique may also help physicians predict which patients will respond well to radiation therapy or achieve longer progression-free survival.

In the study, investigators analyzed saliva samples from 10 patients diagnosed with HPV-OPC using traditional methods.

They found that the technique identified the tumour biomarker in 80 per cent of the cases when coupled with the traditional detection method called droplet digital PCR.

Also Read- Here are Tips to be Stylish this Winter Season

“The saliva exosome liquid biopsy is an effective early detection and risk assessment approach for OPC,” said co-lead investigator David TW Wong from University of California-Los Angeles.

According to the researchers, this technology can also be used to analyze other biofluids such as blood, urine and plasma. (IANS)