Tuesday March 26, 2019

Researchers Discover Novel Drug to Delay Ageing

Besides, the blood chemistry of the mice that underwent drug treatment was also found to have no adverse effects as it was similar to the untreated mice

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Go Makeup Free Once a Week to Delay Ageing
Go Makeup Free Once a Week to Delay Ageing. (Wikimedia commons)

Researchers, including one of Indian origin, have developed a new drug that can delay ageing demonstrated by declining muscle mass, strength and function.

As human bodies age, they increasingly lose the ability to repair and rebuild degenerating skeletal muscles. This can dramatically limit the ability of older adults to live fully active and independent lives.

In the study, researchers from the University of Texas Medical Branch (UTMB) at Galveston identified a protein called Nicotinamide N-methyltransferase (NNMT) in muscle stem cells that appears to be responsible for the age-related dysfunction.

They developed a small molecule drug, NNMT inhibitor (NNMTi), which when prescribed to aged mice could limit NNMT’s effects as well as significantly increase muscle size, strength and metabolic state in the animals.

By resetting muscle stem cells to a more youthful state, the mice could be rejuvenated so that they could more effectively repair muscle tissues, the researchers explained.

“There are no treatments currently available to delay, arrest or reverse age-related muscle degeneration,” said Harshini Neelakantan, research scientist at UTMB.

Makeup can speed up the process of ageing.
Slow down skin ageing by this drug. Pixabay

“These initial results support the development of an innovative drug treatment that has the potential to help the elderly to become fitter, faster and stronger, thus enabling them to live more active and independent lives as they age,” she added.

For the study, published in Biochemical Pharmacology, the team treated ageing mice, suffering from muscle injury, with the drug or a placebo.

Following seven days of treatment, researchers saw that the aged mice, which received the drug, had more functional muscle stem cells than the placebo mice.

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Moreover, the size of the muscle fibres doubled and the strength also increased significantly.

Besides, the blood chemistry of the mice that underwent drug treatment was also found to have no adverse effects as it was similar to the untreated mice. (IANS)

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Researchers Find Molecular Link Between Oestrogen and Bone Ageing

In addition, Sema3A was found to promote the survival of osteocytes -- bone cells -- in these mice

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oestrogen therapy can increase working memory under stress
oestrogen therapy can increase working memory under stress. wikimedia commons

Researchers have found a new molecular link between oestrogen and bone ageing, which may eventually lead to new strategies to treat osteoporosis among post-menopausal women.

Osteoporosis is a condition in which bones become weak and prone to fractures.

Women over 50 are at a high risk of developing osteoporosis, which may be due to the loss of oestrogen that occurs after menopause.

“Over the last few decades, we’ve learned that oestrogen plays an important role in maintaining a functional bone matrix,” said Tomoki Nakashima from the Tokyo Medical and Dental University (TMDU) in Japan.

However, how oestrogen does this, was not fully understood, the researchers said.

bone loss
Decoded: How does oestrogen protect bones? Check it out here.

In the study, the researchers discovered a protein called Sema3A, which was found to maintain bone matrix — proteins and minerals in bone — suggesting a relationship between oestrogen and Sema3A.

Further, the researchers found that blood serum levels of the protein Sema3A decreased in pre-menopausal women as they get older and dropped even more once they reach menopause.

In the study done on mice, the ovaries of mice were removed but it was found that the loss of oestrogen did not prevent their bones from deteriorating.

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In addition, Sema3A was found to promote the survival of osteocytes — bone cells — in these mice.

“We believe that as women lose oestrogen with age and Sema3A levels drop, osteocytes begin to die and bone loses the ability to maintain its supportive structure,” Mikihito Hayashi from the varsity said. (IANS)