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A Congolese health worker administers Ebola vaccine to a woman who had contact with an Ebola sufferer in the village of Mangina in North Kivu province of the Democratic Republic of Congo

Scientists, including one of Indian-origin, have found that the novel synthetic DNA vaccine is safe against Ebola virus and offers a long-term alternative to traditional vaccines.

The team, from The Wistar Institute in Philadelphia, US, optimised a shorter, dose-sparing, immunisation regimen and simplified vaccine that can be directly administered into the skin. They targeted a virus surface protein called glycoprotein.


This new approach induced rapid and protective immunity from virus challenges.

Importantly, the approach showed strong immune responses one year after the last dose, supporting the long-term immunogenicity of the vaccine — a particularly challenging area for Ebola vaccines.


A boy runs past a dispenser containing water mixed with disinfectant, east of Mbandaka, DRC. VOA

“Synthetic non-viral based DNA technology allows for rapid vaccine development by delivery directly into the skin, resulting in consistent, potent and rapid immunity compared to traditional vaccine approaches,” said lead researcher David B. Weiner, Director of Wistar’s Vaccine and Immunotherapy Center.

“An anti-Ebola virus DNA vaccine like this may provide an important new tool for protection, and we are excited to see what future studies will unveil,” he added.

In the study, published in the Journal of Infectious Diseases, the team detected antibody levels were equal or higher to those reported for other vaccines currently being evaluated in the clinic.

“The success of intradermal delivery of a low-dose regimen is very encouraging,” said Ami Patel, Ph.D., associate staff scientist in the Weiner Lab. “The ultimate goal of our work is to create effective and safe vaccines that are optimised for field use in at-risk areas.”


Photo taken Sept 9, 2018, shows health workers walking with a boy suspected of having the Ebola virus at an Ebola treatment centre in Beni, Eastern Congo. VOA

Ebola virus disease is a serious and often fatal illness that can cause fever, headache, muscle pain, weakness, fatigue, diarrhoea, vomiting, stomach pain and haemorrhage (severe bleeding).

First discovered in humans in 1976 in the Democratic Republic of the Congo, the largest outbreak occurred in West Africa from 2014 to 2016, which claimed more than 11,000 lives, according to the World Health Organization.

Also Read: Ebola Increases The Number of Orphans in DRC: UNICEF

The death rate is about 50 per cent and the virus is spread by contact with contaminated body fluids, including blood and semen.

While there are no licensed treatments available for Ebola virus disease yet, multiple experimental therapies are being developed. (IANS)


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NASA's Chandra X-ray Observatory has for the first time spotted signs of a planet transiting a star outside of the Milky Way galaxy, opening up a new avenue to search for exoplanets at greater distances than ever before.

The possible exoplanet -- or planets outside of our Solar System -- candidate is located in the spiral galaxy Messier 51 (M51), also called the Whirlpool Galaxy because of its distinctive profile, NASA said in a statement.

Astronomers have, so far, found all other known exoplanets and exoplanet candidates in the Milky Way galaxy, almost all of them less than about 3,000 light-years from Earth.

An exoplanet in M51 would be about 28 million light-years away, meaning it would be thousands of times farther away than those in the Milky Way, NASA said.

"We are trying to open up a whole new arena for finding other worlds by searching for planet candidates at X-ray wavelengths, a strategy that makes it possible to discover them in other galaxies," said Rosanne Di Stefano of the Center for Astrophysics at Harvard and Smithsonian (CfA) in Cambridge, Massachusetts, who led the study.

The findings are published in the journal Nature Astronomy.

The exoplanet candidate was spotted in a binary system called M51-ULS-1, located in M51. This binary system contains a black hole or neutron star orbiting a companion star with a mass about 20 times that of the Sun. The X-ray transit they found using Chandra data lasted about three hours, during which the X-ray emission decreased to zero.

Based on this and other information, the team estimates the exoplanet candidate in M51-ULS-1 would be roughly the size of Saturn and orbit the neutron star or black hole at about twice the distance of Saturn from the Sun.

The team looked for X-ray transits in three galaxies beyond the Milky Way galaxy, using both Chandra and the European Space Agency's XMM-Newton. Their search covered 55 systems in M51, 64 systems in Messier 101 (the "Pinwheel" galaxy), and 119 systems in Messier 104 (the "Sombrero" galaxy).

However, more data would be needed to verify the interpretation as an extragalactic exoplanet. One challenge is that the planet candidate's large orbit means it would not cross in front of its binary partner again for about 70 years, thwarting any attempts for a confirming observation for decades, NASA said.

Named in honor of the late Indian-American Nobel laureate, Subrahmanyan Chandrasekhar, the Chandra X-ray Observatory is the world's most powerful X-ray telescope. It has eight times greater resolution and is able to detect sources more than 20-times fainter than any previous X-ray telescope.

Known to the world as Chandra (which means "moon" or "luminous" in Sanskrit), Chandrasekhar was widely regarded as one of the foremost astrophysicists of the twentieth century. (IANS/JB)


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