Never miss a story

Get subscribed to our newsletter


×
A Congolese health worker administers Ebola vaccine to a woman who had contact with an Ebola sufferer in the village of Mangina in North Kivu province of the Democratic Republic of Congo

Scientists, including one of Indian-origin, have found that the novel synthetic DNA vaccine is safe against Ebola virus and offers a long-term alternative to traditional vaccines.

The team, from The Wistar Institute in Philadelphia, US, optimised a shorter, dose-sparing, immunisation regimen and simplified vaccine that can be directly administered into the skin. They targeted a virus surface protein called glycoprotein.


This new approach induced rapid and protective immunity from virus challenges.

Importantly, the approach showed strong immune responses one year after the last dose, supporting the long-term immunogenicity of the vaccine — a particularly challenging area for Ebola vaccines.


A boy runs past a dispenser containing water mixed with disinfectant, east of Mbandaka, DRC. VOA

“Synthetic non-viral based DNA technology allows for rapid vaccine development by delivery directly into the skin, resulting in consistent, potent and rapid immunity compared to traditional vaccine approaches,” said lead researcher David B. Weiner, Director of Wistar’s Vaccine and Immunotherapy Center.

“An anti-Ebola virus DNA vaccine like this may provide an important new tool for protection, and we are excited to see what future studies will unveil,” he added.

In the study, published in the Journal of Infectious Diseases, the team detected antibody levels were equal or higher to those reported for other vaccines currently being evaluated in the clinic.

“The success of intradermal delivery of a low-dose regimen is very encouraging,” said Ami Patel, Ph.D., associate staff scientist in the Weiner Lab. “The ultimate goal of our work is to create effective and safe vaccines that are optimised for field use in at-risk areas.”


Photo taken Sept 9, 2018, shows health workers walking with a boy suspected of having the Ebola virus at an Ebola treatment centre in Beni, Eastern Congo. VOA

Ebola virus disease is a serious and often fatal illness that can cause fever, headache, muscle pain, weakness, fatigue, diarrhoea, vomiting, stomach pain and haemorrhage (severe bleeding).

First discovered in humans in 1976 in the Democratic Republic of the Congo, the largest outbreak occurred in West Africa from 2014 to 2016, which claimed more than 11,000 lives, according to the World Health Organization.

Also Read: Ebola Increases The Number of Orphans in DRC: UNICEF

The death rate is about 50 per cent and the virus is spread by contact with contaminated body fluids, including blood and semen.

While there are no licensed treatments available for Ebola virus disease yet, multiple experimental therapies are being developed. (IANS)


Popular

Photo by Diabetesmagazijn.nl on Unsplash

Eating fruits is one of the most satisfying ways to tackle sweet-tooth cravings while meeting your nutritional needs.

By Monika Manchanda

Eating fruits is one of the most satisfying ways to tackle sweet-tooth cravings while meeting your nutritional needs. Despite many studies and research on fruit consumption in diabetes, there are a lot of speculations on the right kind of fruit consumption and its relation to blood sugar levels.

Eating seasonal and locally available fruit has many health benefits ranging from reducing sugar and inflammation levels to fighting high blood pressure -- thanks to their abundant vitamins and mineral presence! They are a powerhouse of antioxidants like vitamins A, B, C, E, and minerals like iron, calcium, magnesium, and fiber.

The fruits listed below are not just diabetic-friendly but are loaded with fiber and water content which can slow down the sugar spikes and sugar absorption rate. Apples are not just nutritious and filling; According to a study, they are significantly associated with a lower risk of type 2 diabetes if consumed in moderation. Turns out there is a truth in the old saying, "An apple a day keeps the doctor away", after all!

red apples Apples are not just nutritious and filling; According to a study, they are significantly associated with a lower risk of type 2 diabetes if consumed in moderation. | Photo by Pierpaolo Riondato on Unsplash

Keep Reading Show less
Photo by Priscilla Du Preez on Unsplash

Your monthly round up of the latest lifestyle launches, from luxury indulgences to artisanal creations.

By Nimerta C Sharan

Your monthly round up of the latest lifestyle launches, from luxury indulgences to artisanal creations, here's what you can look forward to :

Bag This
Exciting news for all handbag lovers, luxury fashion house Louis Vuitton recently launched their limited edition handbags 'Artycapucines - Chapter 3'. Six internationally -- acclaimed artists have transformed the black canvas of the timeless Capucines bag into beautiful art pieces. Each bag will be available in a limited edition of 200 and will be released worldwide at the end of October 2021.

white leather shoulder bag on shopping cart Exciting news for all handbag lovers, luxury fashion house Louis Vuitton recently launched their limited edition handbags. | Photo by Erik Mclean on Unsplash

Keep Reading Show less
IANS

Actress Kangana Ranaut has talked about how her weight adjustments for her latest 'Thalaivii' that "messed up many things" in her body

Actress Kangana Ranaut has talked about how her weight adjustments for her latest 'Thalaivii' that "messed up many things" in her body and left her with "permanent stretch marks". For her role in the film, based on the life of late Tamil Nadu Chief Minister and former actress J. Jayalalithaa, Kangana had to gain 20kg and undergo major physical transformation several times.

She took to Instagram to share her experience, detailing that doing all that over the six months period left her with "permanent stretch marks". "Gaining 20 kgs in 6 months and loosing it all within 6 months that too in my thirties messed up many things in my bodya I also have permanent stretch marks as well but art comes to life with a price and more often than not price is the artist him/herself," she wrote.

"Thalaivii" showcases the varied aspects of Jayalalithaa's life, tracing her journey as an actress at a young age to becoming the face of Tamil cinema, as well as the rise of the revolutionary leader who changed the course of the state's politics. Talking about her upcoming works, Kangana currently has 'Dhaakad'.

She is also shooting for her next 'Tejas', where she plays a fighter pilot. The Indian Air Force was the first of the country's defence forces to induct women into combat roles in 2016. The film takes inspiration from the landmark event. 'Tejas' is directed by debutant Sarvesh Mewara. The film will be RSVP's second film which pays a tribute to the Indian military after the immensely successful film "Uri: The Surgical Strike" which was released in January 2019. (IANS/ MBI)


Keep reading... Show less