Sunday January 19, 2020

Researchers To Develop Novel Therapy For Treating Parkinson’s Disease

Researchers developing new therapy to treat Parkinson's disease

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10 million people living worldwide suffer from Parkinson;s disease Pixabay
10 million people living worldwide suffer from Parkinson;s disease Pixabay

Cell replacement may play an increasing role in alleviating the symptoms such as movement problems and memory loss of Parkinson’s disease (PD), researchers say.

The most common PD treatment today is based on enhancing the activity of the nigrostriatal pathway in the brain with dopamine-modulating therapies, thereby increasing striatal dopamine levels and improving motor impairment associated with the disease.

However, this treatment has significant long-term limitations and side effects.

“We are in desperate need of a better way of helping people with PD. It is on the increase worldwide. There is still no cure, and medications only go part way to fully treat incoordination and movement problems,” said Claire Henchcliffe, MD, from Weill Cornell Medicine in the US.

Parkinsons
Parkinson’s is caused by a lack of dopamine made by brain cells. (IANS)

Recent strides in stem cell technology mean that quality, consistency, activity, and safety can be assured, and that it is possible to grow essentially unlimited amounts of dopamine-producing nerve cells in the laboratory for transplantation, said a study, published in the Journal of Parkinson’s Disease.

“We are moving into a very exciting era for stem cell therapy. The first-generation cells are now being trialed and new advances in stem cell biology and genetic engineering promise even better cells and therapies in the future,” said Malin Parmar, postdoctoral candidate from the Lund University in Sweden.

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“There is a long road ahead in demonstrating how well stem cell-based reparative therapies will work, and much to understand about what, where, and how to deliver the cells, and to whom,” said Parmar. (IANS)

Next Story

Know the Difference between Parkinson’s Disease and Bipolar Disorder

Is there any relationship between Parkinson's disease and Bipolar disorder?

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disorder disease
Parkinsons disease is caused by low levels of a neuro-transmitter called dopamine in the brain, bipolar disorder is due to high levels of the same neurotransmitter. Lifetime Stock

Parkinsons disease and bipolar disorders are two ends of the same spectrum. Whereas, Parkinsons disease (PD) is caused by low levels of a neuro-transmitter called dopamine in the brain, bipolar disorder (BD) is due to high levels of the same neurotransmitter.

IANSlife spoke with Dr Madhuri Behari, Professor & Head, Department of Neurology, Fortis Hospital, Vasant Kunj, to find out what the relationship between the two is.

Dr Behari explains that Dopamine is essential for refined motor activities and all symptoms of Parkinson’s disease like tremour, slowness of actions, stiffness of muscles and postural stability are due to decreased levels of dopamine. Dopamine is also known as the happiness hormone and its decreased levels result in depression.

On the other hand, high levels of Dopamine causes symptoms of bipolar state such as manic behaviour (over-activity, not able to sleep, talkativeness, unnecessarily happy, suspicious behaviour, thinking that everyone is talking about them etc.), hallucination and other symptoms.

Bipolar Disorder
Dopamine causes symptoms of bipolar disorder such as manic behaviour. Lifetime Stock

In India, there is very low awareness about these diseases and because of that there are lots of misunderstandings. The time patient reaches a neurologist the golden time is lost and in most of the cases we become helpless. While Parkinson’s disease is disease of elderly, Bipolar disorder usually occurs in young people. Since, the urban elderly population is living alone, it becomes difficult to track their behaviour for early symptoms of PD or bipolar symptoms due to side effects of high doses of levodopa (medicine given for PD).

It is also noted that in later stages of PD, when the dose of Levodopa or other drugs given to treat PD in high doses as per need of patient, some susceptible people develop mania,

hallucination and psychosis which can be treated by decreasing the dose of medicines and in some cases by doing deep brain stimulation operation. Whereas bipolar disorder can be treated by medicines only. It is highly recommended that we must pay close attention to elderly people to note occurrence of early symptoms of PD or bipolar symptoms.

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Our mind is a machine which realizes that after 40 years of age there is nothing to learn and became stagnant. Constant absence of new learning may lead reduction in levels of certain neurotransmitters, hence it is recommended that we must start learning new brain activities after 40 years of age like learning new language, new hobby etc. to prevent loss of brain functioning or development of memory loss or dementia.

Brain is the most important part of our body which is complex and needs constant activation. While we can exercise our arms, legs, body or neck; similarly brain also needs regular exercise. (IANS)

2 responses to “Know the Difference between Parkinson’s Disease and Bipolar Disorder”

  1. I am 65 years old, I was diagnosed of Parkinson’s disease at the age of 59. I had severe calf pain, muscle pain, slurred speech, frequent falls, loss of balance, difficulty getting up from sitting position. i was on Carbidopa and Pramipexole for two years, as the disease progressed my symptoms worsened, with my neurologist guidance i started on natural PARKINSON’S DISEASE TREATMENT from Rich Herbal garden (ww w. richherbalgardens. c o m). The treatment worked very effectively for my Parkinson’s, most of my severe symptoms simply vanished within the first 3 months on the treatment, i feel better now than I have felt in years and i can feel my strength again. My neurologist was very open when looking at alternative medicines and procedures, this alternative Parkinson’s disease treatment is indeed a breakthrough.

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