Never miss a story

Get subscribed to our newsletter


×
10 million people living worldwide suffer from Parkinson;s disease Pixabay

An experimental treatment that delivers a drug directly to the brain has shown promise for slowing, stopping, or even reversing Parkinson’s disease, say researchers.

The study, by a team led by University of Bristol researchers, in a clinical trial investigated whether the treatment called Glial Cell Line Derived Neurotrophic Factor (GDNF) — a natural protein, found in the brain — can regenerate dying dopamine brain cells in patients with Parkinson’s and reverse their condition, something no existing treatment can do.


The results potentially demonstrated that the new treatment was starting to reawaken and restore damaged brain cells and that repeated brain infusion is clinically feasible and tolerable, according in the Journal of Parkinson’s Disease.

The study “represents some of the most compelling evidence yet that we may have a means to possibly reawaken and restore the dopamine brain cells that are gradually destroyed in Parkinson’s”, said principal investigator Alan L. Whone, from the University of Bristol in the UK.

After an initial safety study of six people, 35 individuals were enrolled in the nine-month double blind trial, in which half were randomly assigned to receive monthly infusions of GDNF and the other half placebo infusions.


Parkinson’s Disease Gets Awareness From Various Events. Flickr

All participants underwent robot-assisted surgery to have four tubes placed into their brains, which allowed GDNF or placebo to be infused directly to the affected areas with pinpoint accuracy, via a port in their head.

After implantation the team administered, more than 1,000 brain infusions, once every four weeks.

After nine months, there was no change in the PET scans of those who received placebo. On the other hand, the group who received GDNF showed an improvement of 100 per cent in a key area of the brain affected in the condition.

Also Read- Now Machine Learning Can Help in Predicting Earthquakes

“This trial has shown that we can safely and repeatedly infuse drugs directly into patients’ brains over months or years,” said Steven Gill, lead neurosurgeon at North Bristol NHS Trust, Bristol, UK

“This is a significant breakthrough in our ability to treat neurological conditions, such as Parkinson’s, because most drugs that might work cannot cross from the blood stream into the brain due to a natural protective barrier.” (IANS)


Popular

Unsplash

Feminism itself is nothing but a simple movement that pursues equal rights for women (including transwomen) and against misogyny both external and internal.

"In India, to be born as a man is a crime, to question a woman is an atrocious crime, and this all because of those women who keep suppressing men in the name of feminism."

Feminism, a worldwide movement that started to establish, define and defend equal rights for women in all sections- economically, politically, and socially. India, being a patriarchal society gives a gender advantage to the men in the society thus, Indian feminists sought to fight against the culture-specific issue for women in India. Feminism itself is nothing but a simple movement that pursues equal rights for women (including transwomen) and against misogyny both external and internal. It states nowhere that women should get more wages than men, that women deserve more respect than men, that's pseudo-feminism.

Keep Reading Show less
wikimedia commons

Yakshi statue by Kanayi Kunjiraman at Malampuzha garden, Kerala

Kerala is a land of many good things. It has an abundance of nature, culture, art, and food. It is also a place of legend and myth, and is known for its popular folklore, the legend of Yakshi. This is not a popular tale outside the state, but it is common knowledge for travellers, especially those who fare through forests at night.

The legend of the yakshi is believed to be India's equivalent of the Romanian Dracula, except of course, the Yakshi is a female. Many Malayalis believe that the Yakshi wears a white saree and had long hair. She has a particular fragrance, which is believed to be the fragrance of the Indian devil-tree flowers. She seduces travellers with her beauty, and kills them brutally.

Keep Reading Show less
Pinterest

Ancient India not only made mentions of homosexuality but accepted it as well.


The LGBTQ+ acronym stands for Lesbian, Gay, Bisexual, Transgender, Queer, and others. In India LGBTQ+ community also include a specific social group, part religious cult, and part caste: the Hijras. They are culturally defined either as "neither men nor women" or as men who become women by adopting women's dress and behavior. Section 377 of the India Penal code that criminalized all sexual acts "against the order of nature" i.e. engaging in oral sex or anal sex along with other homosexual activities were against the law, ripping homosexual people off of their basic human rights. Thus, the Indian Supreme Court ruled a portion of Section 377 unconstitutional on 6th September 2018.

Keep reading... Show less