Wednesday February 20, 2019

Obesity can lead to breast cancer

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By NewsGram Staff Writer

The root cause of many health problems, obesity, can lead to breast cancer as well. A new study has found that obesity results in stiffer breast tissue that promotes the growth of cancer.

Obesity leads to a stiffening of the mesh work material that surrounds fat cells in the breast, called the extracellular matrix, and these bio-mechanical changes create the right conditions for tumours, the findings showed.

ThinkstockPhotos-200302239-001-e1434141030608Women who are obese have a higher risk and a worse prognosis for breast cancer, but the reasons have remained unclear till now.

“We all know that obesity is bad; the metabolism changes and hormones change, so when looking for links to breast cancer, researchers almost exclusively have focused on the biochemical changes happening,” said study senior author Claudia Fischbach, associate professor of biomedical engineering at Cornell University in New York.

“But what these findings show is that there are also biophysical changes that are important,” Fischbach noted.
The findings could lead to recognition of stiffer breast cells as a clinical biomarker for breast cancer.

Also, the results should caution doctors against using certain fat cells from obese women in plastic and reconstructive breast surgeries, as these cells can promote recurring breast cancer.
The findings, published in the journal Science Translational Medicine, suggest clinicians may need to employ finer-scale imaging techniques in mammograms, especially for obese women, to detect a denser fat cells in the breast.

(With inputs from IANS)

 

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Researchers Identify Genes Causing Obesity

Performing functional studies across other organisms, the team also identified two genes that were associated with significant increase in triglyceride and body fat across species

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obese children
India with 14.4 million had the second highest number of obese children in 2015. Pixabay

Researchers have identified genetic variants associated with obesity that is central to developing targeted interventions to reduce the risk of chronic illnesses like hypertension, Type-2 diabetes and heart disease.

The team from the University of North Carolina at Chapel Hill found genetic sites that affect human body’s size and shape, including height and obesity. The findings will help understand how genes can predispose certain individuals to obesity.

In the study, published in the journal Nature Genetics, researchers found 24 coding loci (or positions) — 15 common and nine rare — along chromosomes of individuals that predispose to higher waist-to-hip ratio.

Higher values of waist-to-hip ratio are associated with more incidence of diseases associated with obesity.

Obesity can now be cured by our body's natural weighing scales.
Obesity can now be cured by our body’s natural weighing scales.

“For the first time, we were able to examine, on a large scale, how low-frequency and rare variants influence body fat distribution,” said North.

“A better understanding of the genetic underpinnings of body fat distribution may lead to better treatments for obesity and other downstream diseases obesity also impacts, for example Type-2 diabetes and heart disease,” suggested North.

Also Read- PM Narendra Modi Urges Youth to Stay Away From Drug Addiction as it Helps Anti-national Forces

Further analysis revealed pathways and gene sets that influenced not only metabolism but also regulation of body fat tissue, bone growth and adiponectin, a hormone that controls glucose levels and breaks down fat.

Performing functional studies across other organisms, the team also identified two genes that were associated with significant increase in triglyceride and body fat across species. (IANS)