Saturday July 20, 2019

Obesity can lead to breast cancer

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By NewsGram Staff Writer

The root cause of many health problems, obesity, can lead to breast cancer as well. A new study has found that obesity results in stiffer breast tissue that promotes the growth of cancer.

Obesity leads to a stiffening of the mesh work material that surrounds fat cells in the breast, called the extracellular matrix, and these bio-mechanical changes create the right conditions for tumours, the findings showed.

ThinkstockPhotos-200302239-001-e1434141030608Women who are obese have a higher risk and a worse prognosis for breast cancer, but the reasons have remained unclear till now.

“We all know that obesity is bad; the metabolism changes and hormones change, so when looking for links to breast cancer, researchers almost exclusively have focused on the biochemical changes happening,” said study senior author Claudia Fischbach, associate professor of biomedical engineering at Cornell University in New York.

“But what these findings show is that there are also biophysical changes that are important,” Fischbach noted.
The findings could lead to recognition of stiffer breast cells as a clinical biomarker for breast cancer.

Also, the results should caution doctors against using certain fat cells from obese women in plastic and reconstructive breast surgeries, as these cells can promote recurring breast cancer.
The findings, published in the journal Science Translational Medicine, suggest clinicians may need to employ finer-scale imaging techniques in mammograms, especially for obese women, to detect a denser fat cells in the breast.

(With inputs from IANS)

 

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New Reusable Device Which can Help Women with Breast Cancer in Lower-Income Countries

Innovation in cancer care doesn't always mean that you have to create an entirely new treatment

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Breast Cancer, Device, Women
According to the study published in the journal PLOS One, the research team wanted to create a tissue-freezing tool that uses carbon dioxide. Pixabay

Researchers have developed a new reusable device which can help women with breast cancer in lower-income countries by using carbon dioxide, a widely available and affordable gas, to power a cancer tissue-freezing probe instead of industry-standard argon.

According to the study published in the journal PLOS One, the research team wanted to create a tissue-freezing tool that uses carbon dioxide, which is already widely available in most rural areas thanks to the popularity of carbonated drinks.

“Innovation in cancer care doesn’t always mean that you have to create an entirely new treatment. Sometimes it means radically innovating on proven therapies such that they’re redesigned to be accessible to the majority of the world’s population,” said the study’s first author Bailey Surtees from the Johns Hopkins University.

For the study, the research team tested their tool in three experiments to ensure it could remain cold enough in conditions similar to the human breast and successfully kill tumour tissues.

Breast Cancer, Device, Women
Researchers have developed a new reusable device which can help women with breast cancer in lower-income countries by using carbon dioxide. Pixabay

In the first experiment, the team used the tool on jars of ultrasound gel, which thermodynamically mimics human breast tissue, to determine whether it could successfully reach standard freezing temperatures killing tissues and form consistent iceballs.

In all the trials, the device formed large enough iceballs and reached temperatures below -40 degrees Celsius, which meets standard freezing temperatures for tissue death for similar devices in the United States.

For the second experiment, the team treated 9 rats with 10 mammary tumours. Afterwards, they looked at the tissues under a microscope and confirmed that the tool successfully killed 85 per cent or more tissues for all tumours.

Finally, the team tested the tool’s ability to reach temperatures cold enough for tissue destruction in the normal liver of a pig, which has a temperature similar to a human breast.

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The device was successfully able to stay cold enough during the entire experiment to kill the target tissue. (IANS)