Friday April 26, 2019

Obesity can lead to breast cancer

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By NewsGram Staff Writer

The root cause of many health problems, obesity, can lead to breast cancer as well. A new study has found that obesity results in stiffer breast tissue that promotes the growth of cancer.

Obesity leads to a stiffening of the mesh work material that surrounds fat cells in the breast, called the extracellular matrix, and these bio-mechanical changes create the right conditions for tumours, the findings showed.

ThinkstockPhotos-200302239-001-e1434141030608Women who are obese have a higher risk and a worse prognosis for breast cancer, but the reasons have remained unclear till now.

“We all know that obesity is bad; the metabolism changes and hormones change, so when looking for links to breast cancer, researchers almost exclusively have focused on the biochemical changes happening,” said study senior author Claudia Fischbach, associate professor of biomedical engineering at Cornell University in New York.

“But what these findings show is that there are also biophysical changes that are important,” Fischbach noted.
The findings could lead to recognition of stiffer breast cells as a clinical biomarker for breast cancer.

Also, the results should caution doctors against using certain fat cells from obese women in plastic and reconstructive breast surgeries, as these cells can promote recurring breast cancer.
The findings, published in the journal Science Translational Medicine, suggest clinicians may need to employ finer-scale imaging techniques in mammograms, especially for obese women, to detect a denser fat cells in the breast.

(With inputs from IANS)

 

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Chinese Researchers Reveal Mechanism of Chronic Stress Promoting Breast Cancer Development

Qiang noted that patients with breast cancer, ovarian cancer and stomach cancer often have negative emotions, which in turn accelerates the development of their own tumours

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Breast Cancer
Nano technology offers hope for better cancer testing. Pixabay

Chinese researchers have revealed the mechanism of how chronic stress promotes breast cancer development, shedding light on future clinical treatment for cancer.

Cancer patients often suffer negative emotions such as anxiety, despair and fear, which are risk factors facilitating tumour growth as well as promoting cancer progression. However, the specific mechanisms of how chronic stress affects cancer development remains unknown yet.

Researchers from the Dalian Medical University in China found that chronic stress might increase epinephrine levels, which enhances lactate dehydrogenase A (LDHA) and promotes breast cancer stem-like cells, Xinhua reported.

Using a drug screen that targeted LDHA, they found that Vitamin C reversed the chronic stress-induced cancer stem-like phenotype.

The study demonstrates the critical importance of psychological factors in promoting stem-like properties in breast cancer cells and provides a promising therapeutic approach for breast cancer, according to Liu Qiang, lead researcher at the varsity.

Representational image.

“The LDHA-lowering agent Vitamin C can be a potential approach for combating stress-associated breast cancer,” Qiang said, in the paper published in the Journal of Clinical Investigation.

His team has been engaged in the dynamic regulation of cancer stem cells research as well as the mechanism of psychosocial behaviour affecting tumour development.

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Qiang noted that patients with breast cancer, ovarian cancer and stomach cancer often have negative emotions, which in turn accelerates the development of their own tumours.

“It is necessary to monitor their chronic stress comprehensively by taking psychological assessments as well as conducting blood tests which include epinephrine levels,” Qiang said. (IANS)