Friday December 14, 2018

Obesity During Pregnancy May up Kids’ Risk of Epilepsy

In addition, complications related to neonatal-asphyxia -- the state of being deprived of oxygen --, as well as less severe neonatal complications, were also independently associated with increased risk of childhood epilepsy

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Pregnancy after breast cancer does not increase a woman's risk of a relapse. Pixabay
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Women who are overweight or obese during their pregnancy may significantly increase the risk for children developing epilepsy, a study has showed.

Epilepsy is a disorder in which nerve cell activity in the brain is disturbed, causing seizures.

The results showed that the risk of epilepsy increased by 11 per cent in children of overweight mothers (BMI of 25 to less than 30) compared with children and normal-weight mothers.

While women with grade I obesity (BMI 30 to less than 35) increased the risk 20 by per cent, those with grade II obesity (BMI 35 to less than 40) raised the risk by 30 per cent.

The risk for children with mothers in the grade III obesity category was 82 per cent.

Pregnancy
Representational image. Pixabay

“Given that overweight and obesity are potentially modifiable risk factors, prevention of obesity in women of reproductive age may be an important public health strategy to reduce the incidence of epilepsy,” said Neda Razaz, from the Karolinska Institutet in Sweden.

Maternal overweight and obesity may increase the risk of brain injury, leading to a range of neurodevelopmental disorders, or that maternal obesity might affect neurodevelopment through obesity-induced inflammation, leading to epilepsy, the researchers argued, in the article published online by JAMA Neurology.

Also Read: How to Protect Skin From Sunburn

In addition, complications related to neonatal-asphyxia — the state of being deprived of oxygen –, as well as less severe neonatal complications, were also independently associated with increased risk of childhood epilepsy. (Bollywood Country)

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First Successful Case Of Womb Transplant in Brazil

In the Brazilian case, the recipient had been born without a uterus due to a condition called Mayer-Rokitansky-Küster-Hauser syndrome. The donor was 45 and died of a stroke.

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Womb Transplant
Medical team hold the first baby born via uterus transplant from a deceased donor at the hospital in Sao Paulo, Brazil. VOA

A woman in Brazil who received a womb transplanted from a deceased donor has given birth to a baby girl in the first successful case of its kind, doctors reported.

The case, published in The Lancet medical journal, involved connecting veins from the donor uterus with the recipient’s veins, as well as linking arteries, ligaments and vaginal canals.

It comes after 10 previously known cases of uterus transplants from deceased donors – in the United States, the Czech Republic and Turkey – failed to produce a live birth.

The girl born in the Brazilian case was delivered via caesarean section at 35 weeks and three days, and weighed 2,550 grams (nearly 6 lbs), the case study said.

Dani Ejzenberg, a doctor at Brazil’s Sao Paulo University hospital who led the research, said the transplant – carried out in September 2016 when the recipient was 32 – shows the technique is feasible and could offer women with uterine infertility access to a larger pool of potential donors.

Womb
. The woman’s previously fertilized and frozen eggs were implanted after seven months and 10 days later she was confirmed pregnant.. Pixabay

The current norm for receiving a womb transplant is that the organ would come from a live family member willing to donate it.

“The numbers of people willing and committed to donate organs upon their own deaths are far larger than those of live donors, offering a much wider potential donor population,” Ejzenberg said in a statement about the results.

She added, however, that the outcomes and effects of womb donations from live and deceased donors have yet to be compared, and said the technique could still be refined and optimised.

The first baby born after a live donor womb transplant was in Sweden in 2013. Scientists have so far reported a total of 39 procedures of this kind, resulting in 11 live births.

Experts estimate that infertility affects around 10 to 15 percent of couples of reproductive age worldwide. Of this group, around one in 500 women have uterine problems.

Before uterus transplants became possible, the only options to have a child were adoption or surrogacy.

Infants, baby, WOmb
The case, published in The Lancet medical journal, involved connecting veins from the donor uterus with the recipient’s veins. Pixabay

In the Brazilian case, the recipient had been born without a uterus due to a condition called Mayer-Rokitansky-Küster-Hauser syndrome. The donor was 45 and died of a stroke.

Also Read: Pregnancy is Possible For Survivors of Breast Cancer

Five months after the transplant, Ejzenberg’s team wrote, the uterus showed no signs of rejection, ultrasound scans were normal, and the recipient was having regular menstruation. The woman’s previously fertilized and frozen eggs were implanted after seven months and 10 days later she was confirmed pregnant.

At seven months and 20 days – when the case study report was submitted to The Lancet – the baby girl was continuing to breastfeed and weighed 7.2 kg (16 lb). (VOA)