Friday August 17, 2018

Obesity During Pregnancy May up Kids’ Risk of Epilepsy

In addition, complications related to neonatal-asphyxia -- the state of being deprived of oxygen --, as well as less severe neonatal complications, were also independently associated with increased risk of childhood epilepsy

0
//
11
pregnancy
The risk for children with mothers in the grade III obesity category was 82 per cent. Pixabay
Republish
Reprint

Women who are overweight or obese during their pregnancy may significantly increase the risk for children developing epilepsy, a study has showed.

Epilepsy is a disorder in which nerve cell activity in the brain is disturbed, causing seizures.

The results showed that the risk of epilepsy increased by 11 per cent in children of overweight mothers (BMI of 25 to less than 30) compared with children and normal-weight mothers.

While women with grade I obesity (BMI 30 to less than 35) increased the risk 20 by per cent, those with grade II obesity (BMI 35 to less than 40) raised the risk by 30 per cent.

The risk for children with mothers in the grade III obesity category was 82 per cent.

Pregnancy
Representational image. Pixabay

“Given that overweight and obesity are potentially modifiable risk factors, prevention of obesity in women of reproductive age may be an important public health strategy to reduce the incidence of epilepsy,” said Neda Razaz, from the Karolinska Institutet in Sweden.

Maternal overweight and obesity may increase the risk of brain injury, leading to a range of neurodevelopmental disorders, or that maternal obesity might affect neurodevelopment through obesity-induced inflammation, leading to epilepsy, the researchers argued, in the article published online by JAMA Neurology.

Also Read: How to Protect Skin From Sunburn

In addition, complications related to neonatal-asphyxia — the state of being deprived of oxygen –, as well as less severe neonatal complications, were also independently associated with increased risk of childhood epilepsy. (Bollywood Country)

Click here for reuse options!
Copyright 2018 NewsGram

Next Story

Researchers Have Successfully Created Artificial Placenta

Initial tests have already shown that the artificial placenta on the chip does in fact behave in a similar way to a natural placenta: small molecules are allowed to pass through, while large ones are held back, the researchers noted.

0
Artificial placenta created in lab using 3D printing. Flickr
Artificial placenta created in lab using 3D printing. Flickr

Using a high-resolution 3D printing process, Austrian researchers have succeeded in creating an artificial placenta barrier on a chip, a development that can be used to investigate important aspects of nutrient transport from the mother to the foetus.

The placenta ensures the exchange of important substances between the mother and her unborn child, whilst simultaneously blocking other substances from passing through.

“The transport of substances through biological membranes plays an important role in various areas of medicine,” said Aleksandr Ovsianikov, professor at the TU Wien university in Vienna.

“These include the blood-brain barrier, ingestion of food in the stomach and intestine, and also the placenta.”

This can help provide clarity on how the exchange of glucose between mother and child takes place. Wikimedia Commons
This can help provide clarity on how the exchange of glucose between mother and child takes place. Wikimedia Commons

Studies have shown that diseases such as diabetes and high blood pressure in the mother can affect the transport of substances to the foetus. Until now however, it has been almost impossible to investigate the way in which the many parameters involved interact in such cases.

Using the 3D printing made it possible to produce customised hydrogel membranes directly within microfluidic chips, which are then populated with placenta cells.

This can help provide clarity on how the exchange of glucose between mother and child takes place, the researchers said.

The novel chip consists of two areas — one represents the foetus, the other the mother. Using a specially developed femtosecond laser-based 3D printing process helped produce a partition between them — the artificial placenta membrane.

The high-resolution 3D printing involved a hydrogel with good biocompatibility.

Also Read: Obesity During Pregnancy May up Kid’s Risk of Epilepsy

“Based on the model of the natural placenta, we produce a surface with small, curved villi. The placenta cells can then colonise it, creating a barrier very similar to the natural placenta,” Ovsianikov explained.

Initial tests have already shown that the artificial placenta on the chip does in fact behave in a similar way to a natural placenta: small molecules are allowed to pass through, while large ones are held back, the researchers noted. (IANS)