Friday February 23, 2018

Women can Boost their Working Memory with Hormone Therapy

Benefits of oestrogen therapy in women.

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oestrogen therapy can increase working memory under stress
oestrogen therapy can increase working memory under stress. wikimedia commons
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New York, Nov 5: Undergoing a type of hormone replacement therapy — used for menopausal treatment — may help protect as well as improve working memory for some women as they age, according to a new study.

Hormone replacement therapy uses female hormones – oestrogen and progesterone – to treat common symptoms of menopause and ageing.

The findings showed that women taking oestrogen-only therapy had lower levels of the stress hormone cortisol and performed better on tests of “working memory” following exposure to stress compared to women taking a placebo.

“Our study suggests that oestrogen treatment after menopause protects the memory that is needed for short-term cognitive tasks from the effects of stress,” said lead author Alexandra Ycaza Herrera, a researcher at the University of Southern California – Davis.

To measure the effect of oestrogen therapy on working memory under stress, the team recruited 42 women with an average age of 66.

Half of the postmenopausal women had been on estradiol — a type of oestrogen therapy — for approximately five years, while the others had received a placebo.

The researchers, in the paper published in the Journal of Clinical Endocrinology and Metabolism, collected saliva to measure the women’s levels of cortisol, oestrogen, and progesterone.

They also ran a test of working memory called a “sentence span task”, in which the women were each given a series and then asked whether each sentence made sense. They also were asked to recall the last word of each one.

While women receiving oestrogen therapy had a smaller increase in cortisol and showed no decrease in working memory function, even after being exposed to stressful situation, those taking the placebo experienced a spike in cortisol levels as well as demonstrated a decrease in working memory function.

Previous studies have pointed to potential health risks — the Ahigher risk of breast cancer, heart disease, stroke and blood clots — of the treatment.

Thus, Herrera noted that “hormone replacement therapy may not be right for every woman, but women need to be able to have the conversation with their doctors”.(IANS)
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Tiny Pacemakers Could Be Game Changers for Heart Patients

A pacemaker is a medical device which uses electrical impulses, delivered by electrodes contracting the heart muscles, to regulate the beating of the heart

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The tiny pacemakers are not right for all patients, but as the technology develops, more people will be able to benefit from the procedure.
The tiny pacemakers are not right for all patients, but as the technology develops, more people will be able to benefit from the procedure. Wikimedia Commons

Tiny, new pacemakers are making headway around the world. One type, the Micra, is keeping 15,000 people’s hearts beating in 40 countries, according to manufacturer Medtronic. One of those people is Mary Lou Trejo, a senior citizen who lives in Ohio.

A healthy heart has its own pacemaker that establishes its rhythm, but people like Trejo need the help of an artificial device.

Trejo comes from a family with a history of heart disease. Her heart skipped beats, and she could feel it going out of rhythm. Trejo wanted to do something to advance heart health, so in 2014, she volunteered to participate in a clinical trial for the Micra pacemaker. The device is 24 millimetres long implanted, one-tenth the size of traditional pacemakers.

Traditional pacemakers

Most pacemakers rely on batteries placed under the skin, usually just below the collarbone. Sometimes patients get infections after the surgery or have difficulty healing from the incision.

Also Read: Lia, the Pregnancy Test You Can Flush

Traditional pacemakers use leads with electrodes on one end that are threaded through blood vessels to connect to the heart. There can be problems with the leads as well.

A healthy heart has its own pacemaker that establishes its rhythm, but people like Trejo need the help of an artificial device.
A healthy heart has its own pacemaker that establishes its rhythm, but people like Trejo need the help of an artificial device. Wikimedia Commons

Dr Ralph Augostini at Ohio State’s Wexner Medical Center says a tiny pacemaker like the Micra avoids all of these problems.

“The electrodes are part of the can, and therefore it eliminates the lead,” he said. There’s no incision in the chest to become infected and no chance of complications with the leads.

Small and self-contained

Augostini implanted Trejo’s pacemaker in 2014. He threaded the entire device through an artery in her leg up to her heart. The pacemaker has small, flexible tines that anchor it into the folds of the heart muscle. Once it’s in place, the doctor gives it a tug to make sure the pacemaker is stable before removing the catheter used to place it in the heart.

The Wexner Medical Center was one of the sites that participated in the Micra clinical trial. Since the Micra received FDA approval in 2016, Medtronic has been training more physicians on the procedure. A company spokesman told VOA that this device is becoming available at other centres across the U.S. and countries throughout the world.

Traditional pacemakers use leads with electrodes on one end that are threaded through blood vessels to connect to the heart.
Traditional pacemakers use leads with electrodes on one end that are threaded through blood vessels to connect to the heart. Wikimedia Commons

Dr John Hummell, a cardiologist at the Wexner Medical Center, has studied the effectiveness of this new generation of pacemakers.

“We don’t leave any wires behind and the pacemaker, the battery, the wire is all just a tiny little piece of metal sitting down in the heart,” he said. Medtronic said the results of the clinical trial showed a success rate of 99.6 percent.

Dr Richard Weachter, with the University of Missouri Health Care, says the leadless pacemakers’ complication rates are about half the rate of traditional pacemakers.

The battery lasts for 14 years and after that, Weachter said, doctors, can implant another one in the same chamber of the heart. They can repeat the procedure a third time if needed.

Also Read: Novel stroke treatment repairs damaged brain tissue

The pacemaker activates only when necessary to keep the heart beating normally. Studies show that the Micra and other leadless pacemakers are safe and effective.

These tiny pacemakers are not right for all patients, but as the technology develops, more people will be able to benefit from the procedure. Four years after her implant, Trejo’s doctors say she is doing fine. (VOA)