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A novel single-shot nanoparticle vaccine developed by MIT researchers could assist efforts to eradicate polio worldwide.

Currently, two to four polio vaccine injections are required to build up immunity, and because of the difficulty in reaching children in remote areas, the disease still prevails.


The novel vaccine delivers multiple doses in just one injection to prevent the paralysis caused by the polio virus.

“Having a one-shot vaccine that can elicit full protection could be very valuable in being able to achieve eradication,” said Ana Jaklenec, a research scientist at MIT’s Koch Institute for Integrative Cancer Research in Cambridge, US.

“Children in some of these hard-to-reach developing world locations tend to not get the full series of shots necessary for protection. The goal is to ensure that everyone globally is immunized,” Jaklenec added, in a paper appearing in the journal Proceedings of the National Academy of Sciences.

To create a single-injection vaccine, the team encapsulated the inactivated polio vaccine in a biodegradable polymer known as PLGA.


An Afghan child looks on as a health worker administers polio vaccine .

This polymer can be designed to degrade after a certain period of time, allowing the researchers to control when the vaccine is released.

The researchers designed particles that would deliver an initial burst at the time of injection, followed by a second release about 25 days later.

They injected the particles into rats, and found that the blood samples from rats immunised with the single-injection particle vaccine had an antibody response against polio virus just as strong as, or stronger than, antibodies from rats that received two injections of Salk polio vaccine — the first polio vaccine, developed in the 1950s.

Furthermore, the researchers said that they could design vaccines that deliver more than two doses, each a month apart and hope to soon be able to test the vaccines in clinical trials.

Also Read: Parents More Worried About the Vaccines Rather Than the Disease

They are also working to apply this approach to create stable, single-injection vaccines for other viruses such as Ebola and HIV. (IANS)


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Hackers have stolen crypto tokens worth $120 million from Blockchain-based decentralised finance (DeFi) platform BadgerDAO.

Hackers have stolen crypto tokens worth $120 million from Blockchain-based decentralised finance (DeFi) platform BadgerDAO. Several crypto wallets were drained before the platform could stop the cyber attack. In a tweet, Badger said it has received reports of unauthorised withdrawals of user funds. "As Badger engineers investigate this, all smart contracts have been paused to prevent further withdrawals. Our investigation is ongoing and we will release further information as soon as possible," the company said late on Thursday.

According to the blockchain security and data analytics Peckshield, the various tokens stolen in the attack are worth about $120 million, reports The Verge. According to reports, someone inserted a malicious script in the user interface (UI) of their website. Badger has retained data forensics experts Chainalysis to explore the full scale of the incident and authorities in both the US and Canada have been informed. "Badger is cooperating fully with external investigations as well as proceeding with its own," it said. DeFi is a collective term for financial products and services that are open, decentralised and accessible to anyone. DeFi products open up financial services to anyone with an internet connection and they are largely owned and maintained by their users. While the attack didn't reveal specific flaws within Blockchain tech itself, it managed to exploit the older "web 2.0" technology that most users need to use to perform transactions, according to reports. (IANS/ MBI)


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Kishan said that the organisers have been asked to strictly follow all Covid-19 protocols.

A total of 120 top Bollywood and other celebrities are expected to attend the wedding of film stars Katrina Kaif and Vicky Kaushal which is scheduled on December 9 in Rajasthan, said Rajendra Kishan, the District Collector (DC) of Sawai Madhopur district of the state on Friday. The District Collector told mediapersons: "These 120 guests shall follow all COVID-19 protocols and fully vaccinated guests will get entry in the much-hyped celebrity wedding."

Kishan said that the organisers have been asked to strictly follow all Covid-19 protocols. Also, those who are not vaccinated, will not be allowed without the negative RT-PCR test report, he added. "We have been informed by organisers that a total of 120 guests are invited to the wedding and the events will take place between December 7 to December 10," he added.

Earlier at 10.30 a.m., Kishan called a meeting which was attended by administrative, police and forest department officials, hotel and event managers to ensure adequate arrangements for crowd control, smooth regulation of traffic, and law and order situation amid the VIP movement. The wedding venue Fort Barwara, that has been converted into a heritage hotel, is situated in the panchayat samiti Chauth Ka Barwara. The venue is around 22 km away from Sawai Madhopur and is around 174 km from Jaipur. Sawai Madhopur district is famous for the Ranthambore National Tiger Reserve and as per reports, the guests are likely to be taken for a tiger safari. (IANS/ MBI)


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The National Centre for Biological Sciences (NCBS) is continuously monitoring the situation in four cities - Bengaluru, Hyderabad, New Delhi, and Pune.

The National Centre for Biological Sciences (NCBS), which confirmed the first two cases of the Omicron variant in Bengaluru on Thursday, is continuously monitoring the situation in four cities - Bengaluru, Hyderabad, New Delhi, and Pune. The NCBS is a part of a consortium of national laboratories performing genomic surveillance across four city clusters. The consortium was established four months ago with support from The Rockefeller Foundation's Pandemic Prevention Institute, and is led by the Centre for Cellular and Molecular Biology (CCMB) in Hyderabad.

Dr Rakesh Mishra at the CCMB said on Friday that the consortium is continuously monitoring the situation in all the four cities and has upscaled its efforts to sequence as many samples as possible Apart from the CCMB and the NCBS, the consortium includes CSIR-Institute of Genomics and Integrative Biology - IGIB in New Delhi and the Pune Knowledge Cluster, Indian Institute of Science Education and Research (IISER), Pune, and CSIR-National Chemical Laboratory in Pune.

covid virus The first case of the Omicron variant was detected in South Africa and reported to the World Health Organization on November 24. | Unsplash

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