Tuesday August 14, 2018

Do you regularly take opioids and anti-depressants? This study says it may increase bone diseases

The researchers evaluated 11,049 rheumatoid arthritis patients, aged 40 and above, with no signs of osteoporotic fractures prior to the tests. After a median follow-up time of 5.7 years, the study found 863 patients affected with osteoporotic fractures.

0
//
91
bone
Anti-depressants may increase the risk of developing bone fractures, says a new study
Republish
Reprint

New York, November 6, 2017 : Consuming opioids and anti-depressants may increase the risk of developing bone fractures among people who are already suffering from rheumatoid arthritis, says a new study.

Rheumatoid arthritis is a chronic disease that causes pain, stiffness, swelling, and limitation in the motion and function of multiple joints and organs of the body.

Chronic inflammation and pain in arthritis patients further leads to several diseases like cardiovascular, mental and gastrointestinal disorders. People take multiple medications in such cases that sometimes influences the risk of osteoporotic fractures or a disease caused due to reduced bone density, the researchers noted.

ALSO READ Importance of Magnesium in Human body, Strenghtens bones

“Even at younger ages, rheumatoid arthritis is associated with a two-fold increased risk of osteoporosis and fractures due to chronic inflammation and glucocorticoid use. More importantly, osteoporotic fractures significantly contribute to the disability, health-related costs and mortality with substantially higher complication in rheumatoid arthritis patients,” said Gulsen Ozen, researcher at the University of Nebraska Medical Centre.

The researchers evaluated 11,049 rheumatoid arthritis patients, aged 40 and above, with no signs of osteoporotic fractures prior to the tests. After a median follow-up time of 5.7 years, the study found 863 patients affected with osteoporotic fractures.

The patients who developed fractures were significantly older and had higher disease risk and bone fracture risk at the baseline than those patients who did not experience fractures.

The results presented at the ACR/ARHP annual meeting 2017 in San Diego mentioned that the osteoporotic fracture risk increased within 30 days when the patients were given opioids. The associated medications also led to falls in certain cases.

“Knowing the risks associated with the use of these medications can guide rheumatologists and other physicians in choosing the most appropriate management strategies in patients, particularly the ones who have a high fracture or fall risk,” Ozen added. (IANS)

Click here for reuse options!
Copyright 2017 NewsGram

Next Story

Drug Used For Osteoporosis May Help in Reducing Heart Attack Risk

Intake of the drug also reduced the risk of stroke by 18 per cent within five years and 17 per cent within 10 years.

0
A commonly used drug for treating osteoporosis or bone pain may also help reduce the risk of death by cardiovascular, heart attack and stroke, according to a study.
Heart Attack risk can be decreased by drug of osteoporosis, Pixabay

A commonly used drug for treating osteoporosis or bone pain may also help reduce the risk of death by cardiovascular, heart attack and stroke, according to a study.

The report, published in Journal of Bone and Mineral Research, showed that the drug Alendronate could lower the risk of cardiovascular diseases by 67 per cent and heart attacks by 45 per cent within a year.

Intake of the drug also reduced the risk of stroke by 18 per cent within five years and 17 per cent within 10 years.

“Our findings show that Alendronate is potentially cardioprotective in hip fracture patients,” said Ching-Lung Cheung, from the University of Hong Kong.

“Physicians should consider prescribing Alendronate or other similar drugs to patients with hip fracture and patients should also have good compliance with Alendronate treatment, as this is not only good for your bones but also your heart,” Cheung added.

It is used for osteoporosis, osteogenesis imperfecta, and several other bone diseases.
Spine Bones, Pixabay

Alendronate belongs to a class of drugs called bisphosphonates and works by preventing bone breakdown and increasing bone density.

It is used for osteoporosis, osteogenesis imperfecta, and several other bone diseases.

The researchers collected data from 34,991 patients, diagnosed with hip fracture in 2005. Out of these 4,602 patients received osteoporosis treatment during follow up.

Also Read: Healthy Diet May Decrease the Risk of Hearing Loss in Women 

Due to excess cardiovascular adverse events, there is a worldwide crisis in the current treatment of osteoporosis with drug romosozumab.

In 2017, the US Food and Drug Administration (FDA) had rejected romosozumab and requested more data before reaching a decision.

The study, thus, has significant implications in clinical trial design of anti-osteoporosis medications, the researchers said. (IANS)

<