Saturday January 18, 2020

Optimism May Lower Diabetes Risk in Postmenopausal Women: Study

The prevalence of diabetes increases with age, with a 25.2 per cent prevalence in those aged 65 years or older

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The study included 4,697 mothers and 4,832 children. (IANS)

While it is known that a positive personality can help one succeed in life, a new study suggests that traits such as optimism may actually help reduce the risk of developing Type-2 diabetes.

The study examined whether personality traits, including optimism, negativity, and hostility, were associated with the risk of developing Type-2 diabetes in postmenopausal women.

Depression and cynicism were found to be associated with an increased risk of diabetes.

In addition, high levels of hostility were associated with high fasting glucose levels, insulin resistance, and prevalent diabetes.

For the study, published in the journal Menopause, researchers followed 139,924 postmenopausal women amongst which 19,240 cases of Type-2 diabetes were identified.

Diabetes
Representational image. Pixabay

Compared with women who were least optimistic, women who were the most optimistic had a 12 per cent lower risk of incident diabetes, results showed.

In addition, the association of hostility with the risk of diabetes was stronger in women who were not obese compared with women who were.

Hence, low optimism, high negativity and hostility were associated with increased risk of incident diabetes in postmenopausal women, independent of major health behaviours and depressive symptoms, the study concluded.

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“In addition to using personality traits to help us identify women at higher risk for developing diabetes, more individualised education and treatment strategies should also be used,” said Joann Pinkerton, executive director at The North American Menopause Society.

The prevalence of diabetes increases with age, with a 25.2 per cent prevalence in those aged 65 years or older. (IANS)

Next Story

Researchers Develop Non-Fibrillating Form of Human Insulin to Treat Diabetes

Typically, the chemical modification of insulin causes structural destabilisation and inactivation

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Diabetes
The discovery of glycoinsulin presents a promising solution for patients of diabetes. Pixabay

 In a promising discovery that could improve the clinical delivery of insulin for people living with diabetes, researchers have developed a non-fibrillating form of human insulin.

Using a novel glycosylation technique, the research team from the Florey Institute of Neuroscience and Mental Health in Australia, has successfully synthesised an insulin analogue called glycoinsulin that demonstrates the same glucose-lowering effects as native insulin in preclinical studies without fibril formation.

The study, published in the Journal of the American Chemical Society, said that fibrils can arise when insulin compounds aggregate together forming clumps.

For people with diabetes who rely on pump infusions to administer insulin, fibrils pose serious risk in blocking the delivery of insulin which can potentially lead to life threatening under-dosing, it added.

The discovery of glycoinsulin presents a promising solution for patients.

“Not only did our research demonstrate that glycoinsulin does not form fibrils, even at high temperature and concentration, but also that it is more stable in human serum than native insulin,” said study researcher Akhter Hossain.

“Together, these findings could position glycoinsulin as an excellent candidate for use in insulin pumps and a way to improve the shelf life of insulin products,” Hossain added. “We now hope to streamline the manufacturing process for glycoinsulin so this compound can be further investigated in larger, clinical studies,” he added.

Over 25,000 people in Australia and 350,000 people in the US use insulin pumps as part of their diabetes management. In what can cause significant patient burden and medicine wastage, insulin pump infusion sets are required to be replaced every 24-72 hours to mitigate the occurrence of fibrils.

Diabetes
In a promising discovery that could improve the clinical delivery of insulin for people living with diabetes, researchers have developed a non-fibrillating form of human insulin. Pixabay

Critical to the success of the study was the engineering of an insulin-sugar complex from egg yolks using a method jointly developed by collaborators, Associate Professor Ryo Okamoto and Professor Yasuhiro Kajihara, from Osaka University, Japan.

“Typically, the chemical modification of insulin causes structural destabilisation and inactivation, but we were able to successfully synthesise glycoinsulin in a way that retains its insulin-like helical structure,” said study co-author John Wade.

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“The result is an almost fully active insulin analogue which has demonstrated near-native binding to insulin receptors in both lab and animal studies,” Wade added. (IANS)