Wednesday March 27, 2019

Oral Antifungal Drug Linked to Risk of Miscarriage

Thrush during pregnancy can be treated with cream or a tablet inserted in the vagina (a pessary) that contains clotrimazole or a similar antifungal drug

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Miscarriage is the most common complication of pregnancy and affects an estimated one in four pregnancies. Pixabay

Using a common medication to treat vaginal yeast infections during pregnancy could be associated with an increased risk of miscarriage, researchers warned.

While topical treatments are used as the first line for pregnant women with fungal infections, oral drug fluconazole is also used during pregnancy.

The study, published in the journal Canadian Medical Association Journal, showed pregnant women who took oral version of the drug fluconazole were more likely to experience miscarriage than those who did not.

“Our study shows taking oral fluconazole during pregnancy may be associated with higher chances of miscarriage,” said Anick Berard from the University of Montreal, Canada.

Higher doses of oral fluconazole (over 150 mg) during early pregnancy may also be linked with higher chances of giving birth to a baby with heart defect, she added.

Pregnancy, Breast Cancer
Oral antifungal drug raises risk of miscarriage: Study.

The study re-emphasises safe practices during pregnancy, which include correct diagnosis and choosing the safest medication with the largest body of data. For the study, researchers studied data on 441,949 pregnancies.

During pregnancy women often get thrush — a yeast infection caused by the Candida species of fungus, usually Candida albicans — because of changes going on in the body, especially during the third trimester.

Also Read- Cut out on These Specific Foods to Prevent Gastrointestinal Issues

Thrush during pregnancy can be treated with cream or a tablet inserted in the vagina (a pessary) that contains clotrimazole or a similar antifungal drug.

While thrush can also be treated with fluconazole, it should not be taken during pregnancy, or even those trying to get pregnant or breastfeeding, according to the UK National Health Service (NHS). (IANS)

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Study Claims, There Should Be Treatment Options Given for Miscarriage

Miscarriage is the most common complication of pregnancy and affects an estimated one in four pregnancies. 

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Miscarriage is the most common complication of pregnancy and affects an estimated one in four pregnancies. Pixabay

Though miscarriage is a traumatic experience for both parents, resulting in feelings of loss and grief that in some cases can lead to anxiety and depression, women experiencing miscarriage should be offered a choice in the treatment they receive, suggests a study.

Miscarriage is the most common complication of pregnancy and affects an estimated one in four pregnancies.

Although guidelines recommend trying to resolve an unsuccessful pregnancy naturally, the new analysis shows that this is only successful in 70 per cent of cases, and potentially comes with complications that are rarely communicated to patients.

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Some women are more keen on having a quick surgical intervention so that they can resume their lifestyle immediately, some are very keen to avoid surgery and prefer to go with a tablet, and others want to take a more natural approach,” Wattar added. Pixabay

The study from the University of Warwick and Queen Mary University of London, demonstrates little to no difference in medical effectiveness in resolving an unsuccessful pregnancy between medical and surgical options.

Thus, the team recommend the doctors to offer women a choice of treatment options for miscarriage to enable them to make an informed decision that takes account of potential uncomfortable side effects, long waiting times and extended periods of recovery.

“What we have to do is provide women with evidence about the benefits and effectiveness of each treatment option and potential side effects so that they can choose what they feel most comfortable with,” said lead author Bassel Wattar from Warwick Medical School.

“Some women are more keen on having a quick surgical intervention so that they can resume their lifestyle immediately, some are very keen to avoid surgery and prefer to go with a tablet, and others want to take a more natural approach,” Wattar added.

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Miscarriage is the most common complication of pregnancy and affects an estimated one in four pregnancies. Pixabay

For the results, published in the journal Human Reproduction Update, the team reviewed 46 trials involving over 9,000 women who experienced spontaneous loss of pregnancy (miscarriage) before 14 weeks gestation.
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During a miscarriage, the body will aim to resolve the unsuccessful pregnancy naturally but conservative treatment can be painful with increased bleeding, increased likelihood of hospital admission, reduced quality of treatment and reduced satisfaction.

However, surgery which include electric vacuum aspiration, and medical treatment with a tablet were found to have similar effectiveness in treating miscarriage as conservative treatment. (IANS)