Wednesday July 17, 2019

Oral Antifungal Drug Linked to Risk of Miscarriage

Thrush during pregnancy can be treated with cream or a tablet inserted in the vagina (a pessary) that contains clotrimazole or a similar antifungal drug

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Miscarriage is the most common complication of pregnancy and affects an estimated one in four pregnancies. Pixabay

Using a common medication to treat vaginal yeast infections during pregnancy could be associated with an increased risk of miscarriage, researchers warned.

While topical treatments are used as the first line for pregnant women with fungal infections, oral drug fluconazole is also used during pregnancy.

The study, published in the journal Canadian Medical Association Journal, showed pregnant women who took oral version of the drug fluconazole were more likely to experience miscarriage than those who did not.

“Our study shows taking oral fluconazole during pregnancy may be associated with higher chances of miscarriage,” said Anick Berard from the University of Montreal, Canada.

Higher doses of oral fluconazole (over 150 mg) during early pregnancy may also be linked with higher chances of giving birth to a baby with heart defect, she added.

Pregnancy, Breast Cancer
Oral antifungal drug raises risk of miscarriage: Study.

The study re-emphasises safe practices during pregnancy, which include correct diagnosis and choosing the safest medication with the largest body of data. For the study, researchers studied data on 441,949 pregnancies.

During pregnancy women often get thrush — a yeast infection caused by the Candida species of fungus, usually Candida albicans — because of changes going on in the body, especially during the third trimester.

Also Read- Cut out on These Specific Foods to Prevent Gastrointestinal Issues

Thrush during pregnancy can be treated with cream or a tablet inserted in the vagina (a pessary) that contains clotrimazole or a similar antifungal drug.

While thrush can also be treated with fluconazole, it should not be taken during pregnancy, or even those trying to get pregnant or breastfeeding, according to the UK National Health Service (NHS). (IANS)

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Night Shifts During Pregnancy up Miscarriage Risk: Study

For the study, the researchers included nearly 23,000 pregnant women

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Miscarriage is the most common complication of pregnancy and affects an estimated one in four pregnancies. Pixabay

Women who do two or more night shifts a week during pregnancy are likely to have an increased risk of miscarriage, says a new study.

This is because women working at night are exposed to artificial light which disrupts their circadian rhythm or body clock and decreases the release of melatonin — a hormone that regulates sleep-wake cycles and helps in maintaining a successful pregnancy, according to the study published in the Occupational and Environmental Medicine journal.

The findings showed that after the eighth week of pregnancy, women who had worked two or more night shifts had a 32 per cent higher risk of miscarriage compared with women who had not worked any night shifts.

A study shows that radiations from gadgets may increase the risk of miscarriage.
Representational image. IANS

“This may be explained by the decline in the proportion of chromosomally abnormal foetuses with gestational age, which makes an association with environmental exposure more easily detectable among later miscarriages,” said researchers from the Bispebjerg and Frederiksberg Hospital in Denmark.

This is an observational study, and as such, cannot establish cause.

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Previous studies have also stated that women who work in night shifts, even occasionally, are at an increased risk of early menopause, which can heighten the possibility of developing cardiovascular disease, osteoporosis and memory problems.

For the study, the researchers included nearly 23,000 pregnant women. (IANS)