Thursday October 24, 2019

Orange Juice, Leafy Vegetables May Prevent Memory Loss in Older Age

A total of 55 per cent of the participants had good thinking and memory skills, 38 per cent had moderate skills, and seven per cent had poor thinking and memory skills

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orange juice
Orange juice, leafy greens may preserve memory in older men. Pixabay

Men who eat leafy greens, dark orange and red vegetables, berries and drink orange juice may be at a lower risk of developing memory loss in older age, according to a study.

The findings showed that men who ate larger amounts of fruits and vegetables 20 years earlier were less likely to develop thinking and memory problems, whether or not they kept eating larger amounts of fruits and vegetables later.

Men who consumed the most vegetables were 34 per cent less likely to develop poor thinking skills than the men who consumed the least amount of vegetables.

Men who drank orange juice every day were 47 per cent less likely to develop poor thinking skills than the men who drank less than one serving per month. This association was mainly observed for regular consumption of orange juice among the oldest men, the researchers found.

“One of the most important factors in this study is that we were able to research and track such a large group of men over a 20-year period of time, allowing for very telling results,” said Changzheng Yuan from Harvard University’s T.H. Chan School of Public Health in Boston.

Green vegetable
Leafy vegetables. Pixabay

“Our studies provide further evidence dietary choices can be important to maintain your brain health,” Yuan added.

The study, published in the journal Neurology, looked at 27,842 men with an average age of 51 who were all health professionals.

Participants also took subjective tests of their thinking and memory skills at least four years before the end of the study, when they were an average age of 73.

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A total of 55 per cent of the participants had good thinking and memory skills, 38 per cent had moderate skills, and seven per cent had poor thinking and memory skills.

However, the study does not show that eating fruits and vegetables and drinking orange juice reduces memory loss; it only shows a relationship between them, the researchers noted. (IANS)

Next Story

Researchers Discover New Drug Which may Protect Against Memory Loss, Nerve Damage and Other Symptoms of Alzheimer’s Disease

BPN14770, under development by Tetra Therapeutics, could help activate these mechanisms that support nerve health and prevent dementia

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Drug, Memory Loss, Nerve Damage
Preclinical research published in the Journal of Pharmacology and Experimental Therapeutics found that the drug -- called BPN14770 -- deters the effects of amyloid beta, a hallmark protein of Alzheimer's that is toxic to nerve cells. Pixabay

Researchers have discovered a new drug which may protect against memory loss, nerve damage and other symptoms of Alzheimer’s disease.

Preclinical research published in the Journal of Pharmacology and Experimental Therapeutics found that the drug — called BPN14770 — deters the effects of amyloid beta, a hallmark protein of Alzheimer’s that is toxic to nerve cells.

BPN14770, under development by Tetra Therapeutics, could help activate these mechanisms that support nerve health and prevent dementia, even with the progression of Alzheimer’s.

“Such observations imply that Alzheimer’s pathology can be tolerated by the brain to some extent due to compensatory mechanisms operating at the cellular and synaptic levels,” said study researcher Ying Xu, Associate Professor at University at Buffalo.

Drug, Memory Loss, Nerve Damage
Researchers have discovered a new drug which may protect against memory loss, nerve damage and other symptoms of Alzheimer’s disease. Pixabay

“Our new research suggests that BPN14770 may be capable of activating multiple biological mechanisms that protect the brain from memory deficits, neuronal damage and biochemical impairments,” Xu added.

The research conducted in mice, discovered that BPN14770 inhibits the activity of phosphodiesterase?4D (PDE4D), an enzyme that plays a key role in memory formation, learning, neuroinflammation and traumatic brain injury.

PDE4D lowers cyclic adenosine monophosphate (cAMP) — a messenger molecule that signals physiological changes such as cell division, change, migration and death — in the body, leading to physical alterations in the brain.

cAMP has numerous beneficial functions, including improved memory. By inhibiting PDE4D, BPN14770 increases cAMP signalling in the brain, which ultimately protects against the toxic effects of amyloid beta.

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“The role of PDE4D in modulating brain pathways involved in memory formation and cognition, and the ability of our PDE4D inhibitor to selectively enhance this process, has been well studied,” said Mark E. Gurney from Tetra Therapeutics.

“We are very excited by our colleagues’ findings, which now suggest a second protective mechanism of action for BPN14770 against the progressive neurological damage associated with Alzheimer’s disease,” Gurney said.

“Developing effective drugs for memory deficits associated with Alzheimer’s disease has been challenging,” said M. O’Donnell, Professor at University at Buffalo.

“BPN14770 works by a novel mechanism to increase cyclic AMP signalling in the brain, which has been shown to improve memory. The collaborative project has led to clinical trials that will begin to test its effectiveness,” O’Donnell said. (IANS)