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With Ovarian Cancer Deaths Set to Spike by 67%, AI to Rescue: Study

However, the scans cannot give clinicians detailed insight into patients’ likely overall outcomes or on the likely effect of a therapeutic intervention

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Cancer
Cancer Ribbon. Pixabay

With the incidence of ovarian cancer likely to increase by 55 per cent in another 15 years or so, researchers have created an artificial intelligence (AI) software to help best treat ovarian cancer that will pave the way for personalised medicine and expedite relief, a new study says.

The mathematical software tool — TEXLab — can also predict what treatment might be most effective for patients with the World Ovarian Cancer Coalition predicting that deaths will likely increase by 67 per cent by 2035 due to this particular cancer.

The technology can be used to identify patients who are unlikely to respond to standard treatments and offer alternatives as ovarian cancer is the sixth most common cancer in women in the UK that usually strikes after menopause or those with a family history of the disease.

Early detection of the disease could improve survival rates, the study noted.

“Long-term survival rate for patients with advanced ovarian cancer is poor despite advancements in treatments. There is an urgent need for new ways,” said lead author Eric Aboagye, Professor at Imperial College London.

For the study, researchers used the software to identify the aggressiveness of tumours in CT scans and tissue samples from 364 women with ovarian cancer.

The patients were then given a score known as Radiomic Prognostic Vector (RPV) which indicates how severe the disease is, ranging from mild to severe.

Cancer patient
Cancer patient.

The findings, published in Nature Communications, showed that the software was up to four times more accurate for predicting deaths from ovarian cancer than standard methods.

In addition, five per cent of patients with high RPV scores had a survival rate of less than two years, results showed.

High RPV was also associated with chemotherapy resistance and poor surgical outcomes, suggesting that RPV can be used as a potential bio-marker to predict how patients would respond to treatments.

“Our technology is able to give clinicians more detailed and accurate information on how the patients are likely to respond to different treatments, which could enable them to make better and more targeted treatment decisions,” said Aboagye.

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Doctors as of now diagnose ovarian cancer in a number of ways, including a blood test followed by a CT scan that uses X-rays and a computer to create detailed pictures of the ovarian tumour.

This helps clinicians know how far the disease has spread and determines the type of treatment patients receive, such as surgery and chemotherapy.

However, the scans cannot give clinicians detailed insight into patients’ likely overall outcomes or on the likely effect of a therapeutic intervention. (IANS)

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AI-based Google Model Beats Humans in Detecting Breast Cancer

This work, said Google, is the latest strand of its research looking into detection and diagnosis of breast cancer, not just within the scope of radiology, but also pathology

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Google, smart compose
The Google name is displayed outside the company's office in London, Britain. VOA

In a ray of hope for those who have to go for breast cancer screening and even for healthy women who get false alarms during digital mammography, an Artificial Intelligence (AI)-based Google model has left radiologists behind in spotting breast cancer by just scanning the X-ray results.

Reading mammograms is a difficult task, even for experts, and can often result in both false positives and false negatives.

In turn, these inaccuracies can lead to delays in detection and treatment, unnecessary stress for patients and a higher workload for radiologists who are already in short supply, Google said in a blog post on Wednesday.

Google’s AI model spotted breast cancer in de-identified screening mammograms (where identifiable information has been removed) with greater accuracy, fewer false positives and fewer false negatives than experts.

“This sets the stage for future applications where the model could potentially support radiologists performing breast cancer screenings,” said Shravya Shetty, Technical Lead, Google Health.

Digital mammography or X-ray imaging of the breast, is the most common method to screen for breast cancer, with over 42 million exams performed each year in the US and the UK combined.

“But despite the wide usage of digital mammography, spotting and diagnosing breast cancer early remains a challenge,” said Daniel Tse, Product Manager, Google Health.

Together with colleagues at DeepMind, Cancer Research UK Imperial Centre, Northwestern University and Royal Surrey County Hospital, Google set out to see if AI could support radiologists to spot the signs of breast cancer more accurately.

The findings, published in the journal Nature, showed that AI could improve the detection of breast cancer.

artificial intelligence, nobel prize
“Artificial intelligence is now one of the fastest-growing areas in all of science and one of the most talked-about topics in society.” VOA

Google AI model was trained and tuned on a representative data set comprised of de-identified mammograms from more than 76,000 women in the UK and more than 15,000 women in the US, to see if it could learn to spot signs of breast cancer in the scans.

The model was then evaluated on a separate de-identified data set of more than 25,000 women in the UK and over 3,000 women in the US.

“In this evaluation, our system produced a 5.7 per cent reduction of false positives in the US, and a 1.2 per cent reduction in the UK. It produced a 9.4 per cent reduction in false negatives in the US, and a 2.7 per cent reduction in the UK,” informed Google.

The researchers then trained the AI model only on the data from the women in the UK and then evaluated it on the data set from women in the US.

In this separate experiment, there was a 3.5 per cent reduction in false positives and an 8.1 per cent reduction in false negatives, “showing the model’s potential to generalize to new clinical settings while still performing at a higher level than experts”.

Notably, when making its decisions, the model received less information than human experts did.

The human experts (in line with routine practice) had access to patient histories and prior mammograms, while the model only processed the most recent anonymized mammogram with no extra information.

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Despite working from these X-ray images alone, the model surpassed individual experts in accurately identifying breast cancer.

This work, said Google, is the latest strand of its research looking into detection and diagnosis of breast cancer, not just within the scope of radiology, but also pathology.

“We’re looking forward to working with our partners in the coming years to translate our machine learning research into tools that benefit clinicians and patients,” said the tech giant. (IANS)