Friday, November 27, 2020
Home Life Style Health & Fitness Pain-free skin patch developed for management of diabetes

Pain-free skin patch developed for management of diabetes

New York, Dec 27, 2017: There is good news for diabetics as researchers have developed a pain-free skin patch containing dissolvable compounds that responds to blood chemistry to manage glucose automatically.

For millions of people with type 2 diabetes, ongoing vigilance over the amount of sugar, or glucose, in their blood is the key to health. A finger prick before mealtimes and maybe an insulin injection is an uncomfortable but necessary routine.

The new study, published online in the journal Nature Communications, showed that the biochemical formula of mineralised compounds in the patch responds to sugar levels for days at a time.

In a proof-of-concept study performed with mice, the researchers showed that the biochemically formulated patch of dissolvable microneedles can make the management of Type-2 diabetes much easier.

“This experimental approach could be a way to take advantage of the fact that persons with Type-2 diabetes can still produce some insulin,” said Richard Leapman of National Institute of Biomedical Imaging and Bioengineering (NIBIB), part of National Institutes of Health (NIH), US.

“A weekly microneedle patch application would also be less complicated and painful than routines that require frequent blood testing,” Leapman said.

The base of the experimental patch is material called alginate, a gum-like natural substance extracted from brown algae.

It is mixed with therapeutic agents and poured into a microneedle form to make the patch.

“Alginate is a pliable material — it is soft, but not too soft,” said lead researcher Xiaoyuan (Shawn) Chen of NIBIB.

“It has to be able to poke the dermis, and while not a commonly used material for needles, it seems to work pretty well in this case,” Chen said.

Chen’s team infused the alginate with a formula of biochemical particles that stimulates the body’s own insulin production when needed and curtails that stimulation when normal blood sugar concentration is reached.

The responsive delivery system of the patch can meet the body’s need for days instead of being used up all at once, the study said.

Insulin is a hormone made in the pancreas and secreted into the bloodstream to regulate glucose in response to food intake.

It is needed to move glucose from the bloodstream into cells where the sugar can be converted to energy or stored.

In Type-1 diabetes, usually diagnosed in children and young adults, the body does not make insulin at all.

Type-2 diabetes, which can be diagnosed at any age but more commonly as an adult, progressively lessens the body’s ability to make or use insulin.

Untreated, diabetes can result in both vascular and nerve damage throughout the body, with debilitating impacts on the eyes, feet, kidneys, and heart.

Global incidence of all types of diabetes is about 285 million people, of which 90 per cent have Type-2 diabetes.

Many require insulin therapy that is usually given by injection just under the skin in amounts that are calculated according to the deficit in naturally generated insulin in the blood. Insulin therapy is not managed well in half of all cases.

The alternate therapy approach developed by NIBIB researchers may eventually make management of Type-2 diabetes a lot more convenient. (IANS)

STAY CONNECTED

19,120FansLike
362FollowersFollow
1,780FollowersFollow

Most Popular

Iere Theatre Productions Of Trinidad: Preserving Heritage Through Staged Plays

By Dr. Kumar Mahabir Not many Indian parents in India and the Indian Diaspora are inclined to encourage their children to participate in or study...

Digital Transformation Seen in Indian Firms

As pandemic accelerates digital transformation across the spectrum, a Dell Technologies report on Thursday said that 94.7 percent of Indian organizations have fast-tracked some...

Threat To Wildlife of Ganges By Waste Fishing Gear

Researchers have found that waste fishing gear in the Ganges poses a serious threat to wildlife including otters, turtles, and dolphins. The study, published in...

53% Indians Will To Switch Jobs For Remote Work

More than half of the office-goers in India are willing to switch jobs if it meant they could work remotely, said a new survey...

Doctors Suggest Flu Shots For Children & Vaccination For Adults

This year has been a double whammy. These earlier diseases are still prevalent and we have COVID added to the disease spectrum and has...

Early Birth Associated With Risks of Hospital Visit Throughout Childhood

Researchers have found that being born early is associated with a higher risk of hospital admission throughout childhood than being born at full term. Existing...

SpaceX Launches 60 More Starlink Satellites

Elon Musk-run SpaceX on Wednesday launched another successful mission carrying 60 more Starlink satellites on board a Falcon 9 rocket into low-Earth orbit that...

Space Travel Makes Cell’s Energy Production Dysfunctional

Critical parts of a cell's energy production machinery, the mitochondria, can be made dysfunctional due to space travel, says a study. The results, published in...

Recent Comments