Sunday December 8, 2019

Paracetamol intake during pregnancy is hazardous for unborn baby boys, says a new study

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By NewsGram Staff Writer

A new study, which appeared in the journal, Science Translational Medicine, has shown that prolonged use of paracetamol during pregnancy may hinder the testosterone production in unborn baby boys.

As reported by IANS, Rod Mitchell, a clinical research at University of Edinburgh, stated, “This study adds to existing evidence that prolonged use of paracetamol in pregnancy may increase the risk of reproductive disorders in male babies.”

“We would advise that pregnant women should follow current guidance that the painkiller be taken at the lowest effective dose for the shortest possible time,” Mitchell added.

According to the report, the study observed the effects of paracetamol on testosterone production in mice that had grafts of human testicular tissue. These grafts have been shown to mimic how the developing testes grow and function during pregnancy.

The mice were given a daily dose of paracetamol over a period of seven days. The amount of testosterone produced by the human tissue was measured after an hour of the final dose of paracetamol. It was found that there was no effect on testosterone production following 24 hours of paracetamol treatment.

However, after seven days of exposure, the amount of testosterone production was reduced by 45 per cent.

“Further research is required to establish the mechanism by which paracetamol might have this effect,” the team concluded.

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Resistance to Antibiotics Rise Among Indian Patients in Pace

There is increase in resistance to antibiotics including clarithromycin which is undoubtedly a worrisome situation in the country

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Antibiotics
In India, a huge population prefers to consume over-the-counter (OTC) drugs without even consulting a doctor. In the long run, this may make them resistant to most of the Antibiotics including clarithromycin. Pixabay

Resistance to commonly-used Antibiotics like clarithromycin is rising among Indian patients and that too at quite a fast pace, health experts have warned.

Clarithromycin is used to treat a wide variety of bacterial infections. This medication can also be used in combination with anti-ulcer medications to treat certain types of stomach ulcers.

According to the World Health Organization (WHO), antibiotic resistance is one of the biggest threats to global health, food security and development today.

Sunil Sofat, Additional Director, Department of Interventional Cardiology (Adult) at Jaypee Hospital in Noida, said that every antibiotic medicine has its own mechanism to treat diseases.

“Yes, this is true that the resistance to clarithromycin is rising among the Indian patients and that too at quite a fast pace. There are multiple factors for the same but one of the major reasons behind it is self-medication,” Sofat told IANS.

“In India, a huge population prefers to consume over-the-counter (OTC) drugs without even consulting a doctor. In the long run, this may make them resistant to most of the antibiotics including clarithromycin,” Sofat added.

Antibiotics
Resistance to commonly-used Antibiotics like clarithromycin is rising among Indian patients and that too at quite a fast pace, health experts have warned. Pixabay

In a recent study presented at United European Gastroenterology (UEG) Week Barcelona 2019, researchers have found that resistance to clarithromycin, one of the most established antimicrobials used to eradicate Helicobacter pylori (H. pylori), had increased from 9.9 per cent in 1998 to 21.6 per cent last year, with increases in resistance also seen for levofloxacin and metronidazole.

The study, which analysed 1,232 patients from 18 countries across Europe, investigated resistance to antibiotics regularly taken for Helicobacter pylori infection, a harmful bacterium associated with gastric ulcers, lymphoma and gastric cancer.

According to Gaurav Jain, Senior Consultant, Internal Medicine at Dharamshila Narayana Superspeciality Hospital, New Delhi, antibiotic resistance is a major concern.

“In India the consumption of antibiotics without consulting a qualified physician is quite common which is leading to its resistance,” Jain told IANS.

“There is increase in resistance to antibiotics including clarithromycin which is undoubtedly a worrisome situation in the country,” Jain said.

However, Deepak Verma of Internal Medicine at Columbia Asia Hospital, Ghaziabad said: “Most of the cases that we see in India are connected to gram-negative bacteria such as e.coli that causes urinary tract infection (UTI).”

He added that the main causes for antibiotic resistance in India are its rampant misuse where people indulge in self-doctoring as well as taking medicines prescribed by unregistered medical practitioners, including quacks who suggest antibiotics quite indiscriminately.

Antibiotics
According to the World Health Organization (WHO), resistance to Antibiotics is one of the biggest threats to global health, food security and development today. Wikimedia Commons

“They primarily use antibiotics symptomatically which is not a correct method for all ailments — without blood and urine culture. Antibiotics can force the pathogen to develop resistance,” Verma explained.

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“Since the clinical culture in India is different from that of the western countries, the lack of awareness of the right process to prescribe antibiotics increases the chances of people using antibiotics without questioning,” he stressed. (IANS)