Tuesday September 24, 2019

Paracetamol intake during pregnancy is hazardous for unborn baby boys, says a new study

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By NewsGram Staff Writer

A new study, which appeared in the journal, Science Translational Medicine, has shown that prolonged use of paracetamol during pregnancy may hinder the testosterone production in unborn baby boys.

As reported by IANS, Rod Mitchell, a clinical research at University of Edinburgh, stated, “This study adds to existing evidence that prolonged use of paracetamol in pregnancy may increase the risk of reproductive disorders in male babies.”

“We would advise that pregnant women should follow current guidance that the painkiller be taken at the lowest effective dose for the shortest possible time,” Mitchell added.

According to the report, the study observed the effects of paracetamol on testosterone production in mice that had grafts of human testicular tissue. These grafts have been shown to mimic how the developing testes grow and function during pregnancy.

The mice were given a daily dose of paracetamol over a period of seven days. The amount of testosterone produced by the human tissue was measured after an hour of the final dose of paracetamol. It was found that there was no effect on testosterone production following 24 hours of paracetamol treatment.

However, after seven days of exposure, the amount of testosterone production was reduced by 45 per cent.

“Further research is required to establish the mechanism by which paracetamol might have this effect,” the team concluded.

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Paracetamol During Pregnancy Can Risk Child’s Behaviour

Women who take paracetamol during pregnancy are at risk of having children with behaviour problems, warn researchers

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paracetamol, pregnancy, risk, behaviour
The study found an association between paracetamol intake and behavioural issues in children including hyperactivity and attention-deficit disorder. Pixabay

Women who take paracetamol during pregnancy are at risk of having children with behaviour problems, warn researchers.

The study, published in the journal Paediatric and Perinatal Epidemiology, examined whether there were any effects of taking paracetamol in mid-pregnancy and the behaviour of the offspring between the ages of six month and 11 years, with memory and IQ tested up until the age of 17.

“Our findings add to a series of results concerning evidence of the possible adverse effects of taking paracetamol during pregnancy such as issues with asthma or behaviour in the offspring,” said study lead author Jean Golding, Professor at the University of Bristol in the UK.

“It reinforces the advice that women should be cautious when taking medication during pregnancy and to seek medical advice where necessary,” Golding said.

Using questionnaire and school information from Bristol’s Children of the 90s study, researchers examined 14,000 children.

paracetamol, pregnancy, risk, behaviour
Human ovaries exposed to paracetamol for a week in laboratories lost up to 40 per cent of their egg cells. Pixabay

When they were seven months pregnant, 43 per cent of their mothers said they had taken paracetamol “sometimes” or more often during the previous three months.

The researchers examined results of the children’s memory, IQ and pre-school development tests, temperament and behaviour measures.

The study found an association between paracetamol intake and behavioural issues in children including hyperactivity and attention-deficit disorder.

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However, this was no longer the case by the time the children reached the end of primary school.

According to the reseachers, boys appeared to be more susceptible than girls to the possible behavioural effects of the drug.

“It is important that our findings are tested in other studies – we were not in a position to show a causal link, rather an association between two outcomes,” Golding added. (IANS)