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People with diabetes, hypertension and depression might be able to continue taking life saving medications in small doses even while they heal from drug-induced liver injuries, suggests new research.
The findings, published in the journal Drug Metabolism and Disposition, suggests that doctors need not always make patients with drug-induced liver injury stop taking all their medications until the liver healed.
Drug-induced liver injury — when a person accidentally harms their liver by taking medications prescribed by a doctor (or occasionally over the counter drugs) — affects about almost 1 million people globally. “Doctors give patients drugs to treat diseases. No one wants their liver damaged, but it happens all the time,” said Xiaobo Zhong from the University of Connecticut in the US.
When a person takes a medication by mouth, it goes into their stomach and then to the intestines, where it is absorbed into the blood. This blood, in turn, passes first through the liver before reaching the rest of the body. The liver has enzymes that break down medicines.
But different people naturally have more or less of these enzymes. Sometimes, what could be a safe and effective dose in one person is too much for someone else who has different enzyme levels. This is why some individuals are more vulnerable to liver damage, even when taking drugs just as a doctor prescribed.
There is no standard guidance for doctors when a patient gets drug-induced liver damage. Often times they tell the person to stop taking all medications immediately and wait for their liver to recover. But that can take weeks or months.
“But if patients have chronic conditions such as diabetes, hypertension, or depression, their conditions can run out of control,” if they stop taking the medications, Zhong said. And that can be life threatening.
The researchers tested whether mice whose livers had been damaged by acetaminophen (the active ingredient in Tylenol) had lower levels of drug metabolising enzymes, called cytochrome P450 enzymes.
The researchers investigated whether mice with drug-induced liver damage can safely take medications for diabetes, hypertension and depression. It looks like they can, as long as the doses are much smaller than normal, said the study.
Because the damaged liver does not break down the medications as efficiently, they are just as effective at these lower doses. The team still has to test whether these results hold in humans. (IANS)
By Monika Manchanda
Eating seasonal and locally available fruit has many health benefits ranging from reducing sugar and inflammation levels to fighting high blood pressure -- thanks to their abundant vitamins and mineral presence! They are a powerhouse of antioxidants like vitamins A, B, C, E, and minerals like iron, calcium, magnesium, and fiber.
The fruits listed below are not just diabetic-friendly but are loaded with fiber and water content which can slow down the sugar spikes and sugar absorption rate. Apples are not just nutritious and filling; According to a study, they are significantly associated with a lower risk of type 2 diabetes if consumed in moderation. Turns out there is a truth in the old saying, "An apple a day keeps the doctor away", after all!
Star fruit: This sweet and sour fruit is rich in dietary fiber and vitamin C. It also positively impacts anti-inflammatory processes and can help repair cell damage, and it has minimal fruit sugars as well. Kiwi fruit is an excellent source of Vitamin E, K, and potassium, and they are low in fruit sugars as well, which makes it a perfect diabetic-friendly fruit.
Pear are nutrient-rich, and they are known to fight inflammation and improve digestion.? Studies also suggest that consuming pears along with a healthy diet reduces the risk of type 2 diabetes. Orange: This citrus fruit is full of fiber that helps slow down sugar absorption into the bloodstream, and its vitamin C component helps improve immunity levels.
Keywords: Diabetics, Apples, Star fruit, Pear, Melons, Kiwi fruit
By Nimerta C Sharan
Exciting news for all handbag lovers, luxury fashion house Louis Vuitton recently launched their limited edition handbags 'Artycapucines - Chapter 3'. Six internationally -- acclaimed artists have transformed the black canvas of the timeless Capucines bag into beautiful art pieces. Each bag will be available in a limited edition of 200 and will be released worldwide at the end of October 2021.
Looking for a quick festive fashion fix for you and your loved ones? E-commerce giant AJIO has announced it's hottest fashion sale starting September 30, 2021. The shopping platform has roped in stylista Sonam Kapoor as the face of the sale that will offer more than 2500 brands at discounted prices.
The country's leading design house, Good Earth, in collaboration with textile designer Madeline Weinrib will present its collection of 'butah' motif dinnerware and home textiles at the Metropolitan Museum of Arts, New York. The 'Heirloom Project' that honours diverse Islamic design techniques will display curated products from across the globe.
Sweet dreams are made of this! Iconic French patisserie Laduree has opened its first Indian outpost at Delhi's upscale Khan Market. Spread over three floors, the bakery currently has twelve macaron flavours, their signature pastries and tea cakes and other brunch and high-tea items on the menu. Bon appetit.
Bright And Beautiful
Raw Mango's latest festive edit 'Moomal' goes live on their website on September 26, 2021. Inspired by the richness and diversity of Rajasthan, the collection consists of organza and silk saris and shararas, gota lehengas and kurtas and embroidered odhnis. The colours and silhouettes are just right for the upcoming festive season. (IANS/ MBI)
Keywords: Lifestle, AJIO, sale, Deepika PAdukone, saris, Motifs, artisan, art
She took to Instagram to share her experience, detailing that doing all that over the six months period left her with "permanent stretch marks". "Gaining 20 kgs in 6 months and loosing it all within 6 months that too in my thirties messed up many things in my bodya I also have permanent stretch marks as well but art comes to life with a price and more often than not price is the artist him/herself," she wrote.
"Thalaivii" showcases the varied aspects of Jayalalithaa's life, tracing her journey as an actress at a young age to becoming the face of Tamil cinema, as well as the rise of the revolutionary leader who changed the course of the state's politics. Talking about her upcoming works, Kangana currently has 'Dhaakad'.
She is also shooting for her next 'Tejas', where she plays a fighter pilot. The Indian Air Force was the first of the country's defence forces to induct women into combat roles in 2016. The film takes inspiration from the landmark event. 'Tejas' is directed by debutant Sarvesh Mewara. The film will be RSVP's second film which pays a tribute to the Indian military after the immensely successful film "Uri: The Surgical Strike" which was released in January 2019. (IANS/ MBI)
Keywords: Kangana Ranaut, Thalaivii, bollywood, stretc marks, actress, tamil cinema