Wednesday, December 2, 2020
Home Life Style Health & Fitness People with Damaged Livers Can Continue Medication for Diabetes

People with Damaged Livers Can Continue Medication for Diabetes

Even damaged livers can handle medicines for diabetes, BP

People with diabetes, hypertension and depression might be able to continue taking life saving medications in small doses even while they heal from drug-induced liver injuries, suggests new research.

The findings, published in the journal Drug Metabolism and Disposition, suggests that doctors need not always make patients with drug-induced liver injury stop taking all their medications until the liver healed.

Drug-induced liver injury — when a person accidentally harms their liver by taking medications prescribed by a doctor (or occasionally over the counter drugs) — affects about almost 1 million people globally. “Doctors give patients drugs to treat diseases. No one wants their liver damaged, but it happens all the time,” said Xiaobo Zhong from the University of Connecticut in the US.

When a person takes a medication by mouth, it goes into their stomach and then to the intestines, where it is absorbed into the blood. This blood, in turn, passes first through the liver before reaching the rest of the body. The liver has enzymes that break down medicines.

But different people naturally have more or less of these enzymes. Sometimes, what could be a safe and effective dose in one person is too much for someone else who has different enzyme levels. This is why some individuals are more vulnerable to liver damage, even when taking drugs just as a doctor prescribed.

Diabetes
If patients have chronic conditions such as diabetes, hypertension, or depression, their conditions can run out of control if they do not take their medicines. Pixabay

There is no standard guidance for doctors when a patient gets drug-induced liver damage. Often times they tell the person to stop taking all medications immediately and wait for their liver to recover. But that can take weeks or months.

“But if patients have chronic conditions such as diabetes, hypertension, or depression, their conditions can run out of control,” if they stop taking the medications, Zhong said. And that can be life threatening.

The researchers tested whether mice whose livers had been damaged by acetaminophen (the active ingredient in Tylenol) had lower levels of drug metabolising enzymes, called cytochrome P450 enzymes.

The researchers investigated whether mice with drug-induced liver damage can safely take medications for diabetes, hypertension and depression. It looks like they can, as long as the doses are much smaller than normal, said the study.

Also Read- Air Pollution Increases Risk of Developing Kidney Diseases

Because the damaged liver does not break down the medications as efficiently, they are just as effective at these lower doses. The team still has to test whether these results hold in humans. (IANS)

STAY CONNECTED

19,120FansLike
362FollowersFollow
1,779FollowersFollow

Most Popular

Chinese Spacecraft To Bring Lunar Soil From Moon

China's Chang'e-5 mission, intended to bring back around 2 kg of lunar soil and rocks to the earth, touched down on the Moon on...

America’s Favorite Snacks Invented By US Military

From instant coffee to Cheetos, packaged cookies, and energy bars, the U.S. military helped invent many of the snacks Americans love to eat. The effort...

COVID Pandemic Obstructed Global Fight Against AIDS

Tuesday is World AIDS Day, with organizations around the world highlighting the need to support those living with and affected by HIV, the virus...

Focus on Having Healthy Heart To Face COVID

Amid the rising cases of Covid-19 in Delhi-NCR, health experts on Tuesday stressed that along with a focus on overall health, taking special care...

Enchanting Tale On Impact of Social Media

This is among the first books to explore the psychological impact of social media, especially Instagram. Garv Roy Gill and Yahvi Kothari meet by chance...

Book on Range of Issues in India By Ram Madhav

For the last few decades, Ram Madhav, formerly the national General Secretary of the Bharatiya Janata Party (BJP), has been observing and participating in...

Short Film Based On Digital Detox Streaming On OTT

Signal, a short film that highlights how digital detox is the need of the hour, has now dropped on OTT. The 32-minute film revolves...

LVB Write-off To Hurt Investor Sentiments of Smaller Banks

The write-off of Lakshmi Vilas Bank's (LVB) debt is likely to hurt investor sentiment toward lower-rated and smaller Indian banks, which would push up...

Recent Comments