Sunday April 5, 2020

People with Damaged Livers Can Continue Medication for Diabetes

Even damaged livers can handle medicines for diabetes, BP

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Diabetes
People with diabetes, hypertension and depression might be able to continue taking life saving medications in small doses even while they heal from drug-induced liver injuries. Pixabay

People with diabetes, hypertension and depression might be able to continue taking life saving medications in small doses even while they heal from drug-induced liver injuries, suggests new research.

The findings, published in the journal Drug Metabolism and Disposition, suggests that doctors need not always make patients with drug-induced liver injury stop taking all their medications until the liver healed.

Drug-induced liver injury — when a person accidentally harms their liver by taking medications prescribed by a doctor (or occasionally over the counter drugs) — affects about almost 1 million people globally. “Doctors give patients drugs to treat diseases. No one wants their liver damaged, but it happens all the time,” said Xiaobo Zhong from the University of Connecticut in the US.

When a person takes a medication by mouth, it goes into their stomach and then to the intestines, where it is absorbed into the blood. This blood, in turn, passes first through the liver before reaching the rest of the body. The liver has enzymes that break down medicines.

But different people naturally have more or less of these enzymes. Sometimes, what could be a safe and effective dose in one person is too much for someone else who has different enzyme levels. This is why some individuals are more vulnerable to liver damage, even when taking drugs just as a doctor prescribed.

Diabetes
If patients have chronic conditions such as diabetes, hypertension, or depression, their conditions can run out of control if they do not take their medicines. Pixabay

There is no standard guidance for doctors when a patient gets drug-induced liver damage. Often times they tell the person to stop taking all medications immediately and wait for their liver to recover. But that can take weeks or months.

“But if patients have chronic conditions such as diabetes, hypertension, or depression, their conditions can run out of control,” if they stop taking the medications, Zhong said. And that can be life threatening.

The researchers tested whether mice whose livers had been damaged by acetaminophen (the active ingredient in Tylenol) had lower levels of drug metabolising enzymes, called cytochrome P450 enzymes.

The researchers investigated whether mice with drug-induced liver damage can safely take medications for diabetes, hypertension and depression. It looks like they can, as long as the doses are much smaller than normal, said the study.

Also Read- Air Pollution Increases Risk of Developing Kidney Diseases

Because the damaged liver does not break down the medications as efficiently, they are just as effective at these lower doses. The team still has to test whether these results hold in humans. (IANS)

Next Story

Here Are Some Health Benefits of Going Vegan

Veganism is a lifestyle that tries to bar, as far as possible and practicable, all kinds of exploitation of, and cruelty to, animals for food, or any other purpose

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Vegan
Veganism is a lifestyle that tries to bar, as far as possible and practicable, all kinds of exploitation of, and cruelty to, animals for food, or any other purpose. Pixabay

Vegan people follow a plant-based diet and do not eat animal products including dairy, meat, eggs, honey, and gelatin. But, veganism goes beyond the diet.

Veganism is a lifestyle that tries to bar, as far as possible and practicable, all kinds of exploitation of, and cruelty to, animals for food, or any other purpose.

Nutritionist and founder of Diet Podium, Shikha Mahajan, shares these five benefits going vegan has on your health.

Reduced risk of cancer

In 2015, the Worle Health Organisation named red meat a Group 2 Carcinogen, which means it probably causes cancer in humans. WHO placed processed meat in the Group 1 category, which means it is carcinogenic to humans.

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Even small amounts of meat can increase the risk of cancer. A study from Oxford University study also found that eating just 3 rashers of bacon a day can increase cancer risk by 20 percent.

Reduced risk Of diabetes

More and more research is concluding that a plant-based diet can reduce the risk of developing diabetes or even reverse the disease completely.

A study, that included more than 2,000 adults, found those people who increased the number of fruit, vegetables, and nuts in their diet over the duration of 20 years reduced their risk of developing type 2 diabetes by 60 percent more than those who did not.

Enhanced mood

A study done by the Physicians Committee for Responsible Medicine (PCRM) shows a study on its website that looks at the eating patterns and moods of 3,486 people over a five-year period. The study showed that participants who consumed whole, plant foods reported fewer signs of depression.

Vegan
Vegan people follow a plant-based diet and do not eat animal products including dairy, meat, eggs, honey, and gelatin. But, veganism goes beyond the diet. Pixabay

A different study showed that vegetarians usually experience more positive moods than meat-eaters.

Healthy skin

A plant-based diet might boost your beauty regime by assisting your skin in staying healthy. An increasing number of studies are associating dairy to skin problems such as acne. Dairy products have growth hormones and are also sometimes infused with artificial hormones, which can disrupt the human body’s hormone system.

ALSO READ: Find Here if Water Treatment Methods Can Kill Coronavirus Or Not

Fewer cardiovascular diseases

Meat generally contains a high quantity of saturated and trans-fats which can increase blood cholesterol. Cholesterol can create fatty deposits in the blood vessels that increase the risk of stroke, peripheral artery disease, and heart disease. Plant-based foods, by nature, have no dietary cholesterol. A diet high in fat and cholesterol can also lead to high blood pressure. (IANS)