Monday, April 19, 2021
Home Life Style Health & Fitness People with Damaged Livers Can Continue Medication for Diabetes

People with Damaged Livers Can Continue Medication for Diabetes

Even damaged livers can handle medicines for diabetes, BP

People with diabetes, hypertension and depression might be able to continue taking life saving medications in small doses even while they heal from drug-induced liver injuries, suggests new research.

The findings, published in the journal Drug Metabolism and Disposition, suggests that doctors need not always make patients with drug-induced liver injury stop taking all their medications until the liver healed.

Drug-induced liver injury — when a person accidentally harms their liver by taking medications prescribed by a doctor (or occasionally over the counter drugs) — affects about almost 1 million people globally. “Doctors give patients drugs to treat diseases. No one wants their liver damaged, but it happens all the time,” said Xiaobo Zhong from the University of Connecticut in the US.

When a person takes a medication by mouth, it goes into their stomach and then to the intestines, where it is absorbed into the blood. This blood, in turn, passes first through the liver before reaching the rest of the body. The liver has enzymes that break down medicines.

But different people naturally have more or less of these enzymes. Sometimes, what could be a safe and effective dose in one person is too much for someone else who has different enzyme levels. This is why some individuals are more vulnerable to liver damage, even when taking drugs just as a doctor prescribed.

Diabetes
If patients have chronic conditions such as diabetes, hypertension, or depression, their conditions can run out of control if they do not take their medicines. Pixabay

There is no standard guidance for doctors when a patient gets drug-induced liver damage. Often times they tell the person to stop taking all medications immediately and wait for their liver to recover. But that can take weeks or months.

“But if patients have chronic conditions such as diabetes, hypertension, or depression, their conditions can run out of control,” if they stop taking the medications, Zhong said. And that can be life threatening.

The researchers tested whether mice whose livers had been damaged by acetaminophen (the active ingredient in Tylenol) had lower levels of drug metabolising enzymes, called cytochrome P450 enzymes.

The researchers investigated whether mice with drug-induced liver damage can safely take medications for diabetes, hypertension and depression. It looks like they can, as long as the doses are much smaller than normal, said the study.

Also Read- Air Pollution Increases Risk of Developing Kidney Diseases

Because the damaged liver does not break down the medications as efficiently, they are just as effective at these lower doses. The team still has to test whether these results hold in humans. (IANS)

STAY CONNECTED

19,517FansLike
362FollowersFollow
1,773FollowersFollow

Most Popular

‘Lost Golden City’ Of Luxor

By- Khushi Bisht Archeologists recently unearthed a 3000-year-old Egyptian wonder known as the 'Lost Golden City of Luxor,' near the 'Valley of Kings', a burial...

COVID Vaccine Might Be Less Effective For People With Blood Cancer: Study

The two-dose mRNA Covid-19 vaccine may be aless effective' in people undergoing treatment for certain types of blood cancers, researchers have claimed in two new...

Oral Antiviral Drug Shows Potential Prevention Against COVID-19

An experimental oral antiviral drug has shown potential in prevention and treatment of SARS-CoV-2, the virus causing Covid-19 infections, say researchers. The antiviral -- MK-4482...

The Power Of The Placebo Effect

BY- JAYA CHOUDHARY The mind can hold tremendous power over bodies. People walking on coal without showing any signs of discomfort. Ordinary people performing superhuman...

Ashtottaram 47) OṀ MĀTRUBHŨMYAI NAMAH:

By Devakinanda Pasupuleti Ashtottaram 47) OṀ MĀTRUBHŨMYAI NAMAH: OṀ (AUM) -MAA-ṪRU-BHOO-MYAI—NA-MA-H ॐ मातृभूम्यै नमः                                            (Mātru: Mother, one who is honored or worshipped) Please Follow NewsGram on Facebook To Get Latest...

‘As A Hindu I Feel The Kumbh Mela Shouldn’t Have Taken Place’, Says Singer Sonu Nigam

Noted singer Sonu Nigam on Sunday reacted to the Kumbh Mela being made symbolic for this year due to the ongoing Covid-19 pandemic. The...

Scott Rudin To ‘Step Back’ After Bullying Allegations

Amid mounting anger over allegations of bullying, Broadway and Hollywood producer Scott Rudin broke his silence Saturday, saying he was "profoundly sorry" and would...

How Is India’s Second Wave Of Covid-19 Different From First?

The second wave of the coronavirus pandemic in India is different from the first one in September 2020 as the rate of increase in...

Recent Comments