Tuesday September 17, 2019

People Living with HIV Significantly Elevates Risk of Chronic Obstructive Pulmonary Disease (COPD)

They found that people living with HIV are at an increased risk of contracting specific diseases and illnesses

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HIV, COPD, Disease
For the study, published in the journal Clinical Infectious Diseases, researchers combined data from 20 separate observational studies and examined 55 different illnesses. Pixabay

People living with HIV have a significantly elevated risk of Chronic Obstructive Pulmonary Disease (COPD) and coughs, heart disease, pregnancy mortality and sepsis, anemia and bone fractures, according to a study.

For the study, published in the journal Clinical Infectious Diseases, researchers combined data from 20 separate observational studies and examined 55 different illnesses.

They found that people living with HIV are at an increased risk of contracting specific diseases and illnesses, some of which are more commonly associated with ageing.

“By pooling data from different studies, we have been able to show for the first time that even with the rise in life expectancy amongst people living with HIV, this population now seems to be disproportionately affected by chronic illnesses often attributable to lifestyle issues such as smoking, drug and alcohol use or more commonly associated with an older population,” said study researcher Lee Smith from Anglia Ruskin University in the UK.

HIV, COPD, Disease
People living with HIV have a significantly elevated risk of Chronic Obstructive Pulmonary Disease (COPD) and coughs, heart disease, pregnancy mortality and sepsis, anemia and bone fractures. Pixabay

Although the number of people contracting HIV is declining, approximately 1.8 million people are infected every year and HIV remains one of the world’s major health issues.

In recent years, people with HIV have benefited from improved access to antiretroviral treatment. However, increased life expectancy and a lower immunity has meant higher levels of comorbidity, with people living with HIV also more likely to suffer from other illnesses.

The greater prevalence of age-associated diseases may be explained by the persistent immunodeficiency and inflammation connected with HIV. There are also adverse effects associated with antiretroviral treatment.

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Previous studies have also suggested that people with HIV in developed countries, as a population, often exhibit greater risk factors associated with non-AIDS related illnesses, such as smoking, drug use and alcohol use. (IANS)

Next Story

A Potential Treatment For Polycystic Kidney Disease

Researchers have found a potential treatment for polycystic kidney disease, a genetic disorder that causes the kidneys to swell with multiple cysts

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Kidney, Polycystic, Disease, Treatment
Nature Communications shows an approximately 50 per cent reduction in kidney size in afflicted mice following treatment. Pixabay

Researchers have found a potential treatment for polycystic kidney disease, a genetic disorder that causes the kidneys to swell with multiple cysts and can eventually lead to organ failure.

The study published in the journal Nature Communications shows an approximately 50 per cent reduction in kidney size in afflicted mice following treatment.

The drug is now in early clinical trials on human subjects, the researchers said.

Autosomal dominant polycystic kidney disease (ADPKD) affects about 12 million people worldwide, with half developing end-stage kidney disease by the age of 60, according to the study.

Kidney, Polycystic, Disease, Treatment
A man with Kidney Stones suffering from the typical symptom – pain in the sides that radiates down to the groin. Wikimedia Commons

“Once the kidneys have failed, the only options for survival are dialysis or a kidney transplant, a large percentage of ADPKD patients on dialysis die each year while waiting for a donated kidney,” said Indian origin researcher and study senior author Vishal Patel, Associate Professor at the University of Texas Southwestern Medical Centre.

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According to the study, the new treatment showed no evidence of toxicity in animals or human cell tests. It is preferentially delivered to kidneys rather than the liver after being administered.

“We earlier showed that levels of a tiny RNA fragment called microRNA-17 are increased in models of ADPKD.

“MicroRNA-17 interferes with the normal function of other, beneficial RNAs, causing kidney cysts to grow. RGLS4326, as the new drug is called in development, works by blocking the harmful microRNA-17,” Patel added. (IANS)