Saturday December 7, 2019

Pharmacist-led Interventions May Prevent Heart Related Illnesses: Study

Pharmacist-led interventions may prevent heart disease

0
//
Heart diseases
Interventions by pharmacists such as medical review and patient education can prevent heart diseases. Lifetime Stock

Researchers have found that pharmacist-led interventions such as patient education, medication review, and medication management can be pivotal in preventing heart related illnesses.

The study, published in the British Journal of Clinical Pharmacology, support the involvement of pharmacists as healthcare providers in managing patients with hypertension, diabetes and high cholesterol.

“The evidence presented in this review provides an important message to health systems and policymakers regarding the effectiveness of general practice-based pharmacists’ interventions,” said study researcher Abdullah Alshehri from University of Birmingham in the US.

During the finding, the research team assessed medical literature for relevant randomised controlled clinical trials assessing the effectiveness of pharmacist-led interventions delivered in the general practice in reducing the medical risk factors of cardiovascular events.

They identified 21 trials involving a total 8,933 patients.

Healthy heart
Patients receiving pharmacist-led interventions experienced significant reductions in heart diseases. Lifetime Stock

Pharmacist-led interventions included patient education, medication review and counselling, physical assessment, assessing adherence, lifestyle modification, and medication management such as prescribing, adjusting, monitoring, and administering therapy and identifying drug-related problems.

The most frequently used pharmacist-led interventions were medication review and medication management.

Patients receiving pharmacist-led interventions experienced significant reductions in their systolic blood pressure (by an average of -9.33 mmHg); Hemoglobin A1c, a measure of blood sugar levels (by an average of -0.76%); and LDL-cholesterol (by an average of -15.19 mg/dl).

Pharmacist-led interventions also helped patients correctly follow their prescribed medication regimens.

“The significant reductions in blood pressure, blood glucose, and blood cholesterol reported in this meta-analysis, if sustained in clinical practice, could have significant implications for managing hypertension, diabetes and dyslipidaemia that could prevent cardiovascular morbidity and mortality,” Alshehri said.

Also Read- Workout Before Breakfast Can Make You Fit

Alshehri noted that the findings support a greater involvement of pharmacists in general practice.

“This will benefit health organisations by providing cost-effective care associated with greater control of patients’ conditions and their medications,” he said. (IANS)

Next Story

Genetic Variations Influence Risk of Developing Cancer: Study

Study found that variations in the regions that regulate the expression of oncogenes and tumour suppressor genes affect cancer risk

0
Cancer
While minor genetic changes only have a small impact on Cancer risk, the variations analysed in this study are numerous and common in the population. Pixabay

Shedding new light on why some people develop cancer while others do not, a new study has found that a person’s risk of developing cancer is affected by Genetic variations in regions of DNA that do not code for proteins, previously dismissed as “junk DNA”.

This study, published in the British Journal of Cancer, shows that inherited cancer risk is not only affected by mutations in key cancer genes, but that variations in the DNA that controls the expression of these genes can also drive the disease.

The researchers believe that understanding how non-coding DNA affects the development of this disease could one day improve genetic screening for cancer risk.

And in the future, this could lead to new prevention strategies, or help doctors diagnose the disease earlier, when it is more likely to be treated successfully.

“What we found surprised us as it had never been reported before — our results show that small genetic variations work collectively to subtly shift the activity of genes that drive cancer,” said lead researcher of the study John Quackenbush, Professor at Harvard T.H. Chan School of Public Health in the US.

Genetic
Shedding new light on why some people develop Cancer while others do not, a new study has found that a person’s risk of developing cancer is affected by genetic variations in regions of DNA that do not code for proteins, previously dismissed as “junk DNA”. Pixabay

“We hope that this approach could one day save lives by helping to identify people at risk of cancer, as well as other complex diseases,” Quackenbush said.

The researchers investigated 846 genetic changes within non-coding stretches of DNA, identified by previous studies as affecting cancer risk.

These Single Nucleotide Polymorphisms (SNPs) are particular positions in the human genome where a single letter of the genetic code varies between people.

Unlike mutations in coding DNA, such as BRCA, that are rare but significantly raise a person’s risk of developing cancer, non-coding SNPs are relatively common in the population but only slightly increase cancer risk.

The team analysed whether there was a correlation between the presence of a particular SNP and the expression of particular genes.

In total, they looked at over six million genetic variants across 13 different body tissues.

Genetic
The researchers believe that understanding how non-coding DNA affects the development of this disease could one day improve genetic screening for cancer risk. Pixabay

They found that variations in the regions that regulate the expression of oncogenes and tumour suppressor genes affect cancer risk.

The study also revealed that these cancer-risk SNPs tend to be specifically located in regions that regulate the immune system and tissue-specific processes — highlighting the importance of these cellular processes to the development of cancer.

ALSO READ: Rise in Phone-related Injuries Linked to iPhone, Pokemon Go

“While minor genetic changes only have a small impact on cancer risk, the variations analysed in this study are numerous and common in the population,” said Emily Farthing, senior research information manager at British charity Cancer Research UK. (IANS)