Saturday July 20, 2019

Poor Oral Health Associated with Liver Cancer: Study

“The liver contributes to the elimination of bacteria from the human body,” Jordao said

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A patient for a regular check up of their teeth.
Picture shows a person's teeth being checked upon.

Poor oral health is associated with a 75 per cent increased risk of hepatocellular carcinoma (HCC), the most common form of liver cancer, a study suggests.

Published in the United European Gastroenterology Journal, the study investigated the association between oral health conditions and the risk of a number of gastrointestinal cancers, including liver, colon, rectum and pancreatic cancer.

Models were applied to estimate the relationship between cancer risk and self-reported oral health conditions, such as painful or bleeding gums, mouth ulcers and loose teeth.

“Poor oral health has been associated with the risk of several chronic diseases, such as heart disease, stroke and diabetes”, said the study lead author Haydee WT Jordao from Queen’s University Belfast.

According to the researchers, of the 469,628 participants from the UK, 4,069 developed gastrointestinal cancer during the (average) six-year follow up. In 13 per cent of these cases, patients reported poor oral health.

Cancer
Cancer Ribbon. Pixabay

Participants with poor oral health were more likely to be younger, female, living in deprived socio-economic areas and consumed less than two portions of fruit and vegetables per day.

The biological mechanisms by which poor oral health may be more strongly associated with liver cancer, rather than other digestive cancers, is currently uncertain. One explanation is the potential role of the oral and gut microbiome in disease development.

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“The liver contributes to the elimination of bacteria from the human body,” Jordao said.

“When the liver is affected by diseases, such as hepatitis, cirrhosis or cancer, its function will decline and bacteria will survive for longer and therefore have the potential to cause more harm,” he added. (IANS)

Next Story

Know Which Hormone in Female Protects Them From Liver Cancer!

Inhibiting testosterone production in male rodents increased their adiponectin levels and reduced tumour growth. 

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liver
Balversa is the first approved drug in a class known as FGFR inhibitors that targets growth factor receptors involved in cell growth and division. Pixabay

Researchers have discovered that a hormone — present at higher levels in women — can keep them away from liver cancer, suggesting the disease is more common in men.

The study showed that a potential contributor to this gender disparity is adiponectin, a hormone secreted by fat cells that helps control the body’s metabolism.

treatment
Importantly, the study suggested that adiponectin and metformin — a common antidiabetic drug — could be used as novel treatments for liver cancer. Pixabay

The hormone activates two proteins inside liver cells, known as p38 and AMPK, that block cell proliferation and impair tumour growth, said the study, published in the Journal of Experimental Medicine.

“Circulating adiponectin levels have been reported to be higher in women than in men,” said Guadalupe Sabio at the Spanish National Center for Cardiovascular Research (CNIC) in Spain.

Similar to humans, male mice are more also prone to hepatocellular carcinoma (HCC) — the most common form of liver cancer — than females, as the increased levels of adiponectin in female mice protect them from HCC, the study said.

liver
The study showed that a potential contributor to this gender disparity is adiponectin, a hormone secreted by fat cells that helps control the body’s metabolism. Pixabay

Inhibiting testosterone production in male rodents increased their adiponectin levels and reduced tumour growth.

Importantly, the study suggested that adiponectin and metformin — a common antidiabetic drug — could be used as novel treatments for liver cancer.

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Sabio said that adiponectin’s role in HCC is controversial and needed further investigation.

Liver cancer is the fourth leading cause of cancer-related deaths worldwide. (IANS)