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Poor sleep poorly on a regular basis may lead to the fatty arterial plaque buildup known as atherosclerosis that can result in fatal heart disease.
“We’ve discovered that fragmented sleep is associated with a unique pathway — chronic circulating inflammation throughout the bloodstream — which, in turn, is linked to higher amounts of plaques in coronary arteries,” said study senior author Matthew Walker from the University of California in the US.
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For the findings, published in the journal PLOS Biology, the researchers analysed the diagnostic data of more than 1,600 middle-aged and older adults using a national dataset known as the Multi-Ethnic Study of Atherosclerosis.
To isolate the effect of quality on heart health, the study controlled for age, ethnicity, gender, body mass index, sleep disorders, blood pressure and high-risk behaviours such as smoking.
The researchers then tracked the results of the study participants, analysing their blood tests, their calcium scores that can gauge plaque buildup, as well as several different measures of sleep, including wristwatch-assessed sleep across a week and a night in a sleep laboratory that measured electrical brainwave signals.
The final outcome clearly linked disrupted patterns to higher concentrations of circulating inflammatory factors and, specifically, of white blood cells known as monocytes and neutrophils, which are key players in atherosclerosis.
“In revealing this link with chronic inflammation, the findings suggest a missing middleman that is brokering the bad deal between fragmented sleep and the hardening of blood vessels,” Walker said.
“To the best of our knowledge, these data are the first to associate sleep fragmentation, inflammation and atherosclerosis in humans,” said study lead author Raphael Vallat.
The findings linking poor patterns to atherosclerosis via chronic inflammation have major public health implications, researchers said.
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To more accurately gauge one’s sleeping quality, the researchers recommend the use of clinical-grade sleep trackers, because the study found that people’s subjective assessments of their sleep were not reliable.
“This link between fragmented sleep and chronic inflammation may not be limited to heart disease, but could include mental health and neurological disorders, such as major depression and Alzheimer’s disease,” Walker said.
“These are new avenues we must now explore,” the authors wrote. (IANS)
Among the Tamil epics written during the Sangam age, only a few survived to this day. Manimegalai is one such. It is written as a sequel to the Sillapadikaram, taking the story forward of Kovalan and Madhavi's daughter, Manimegalai. The Sillapadikaram is about the injustice of the Madurai kingdom in the execution of Kovalan, which turned Kannagi, his wife into a goddess seeking vengeance for her husband's death. Kovalan, before his death, has an affair with a court dancer, Madhavi, and his daughter, Manimegalai, is said to begin a different tradition among the Tamils.
The epic, written by Sattanar, introduces Buddhism to Dravidian culture, something that has been alien to them for years. Manimegalai is the protagonist, who flees constantly from the pursuit of Chola prince Udhayakumara, and tries to lead an ascetic life. Throughout the plot, Buddhist tenets are used to avoid the culmination of a love-story. Manimegalai is believed to be the anti-love story sequel to the Sillapadikaram.
A complete work of Tamil epic written by hand on leaves Image source: wikimedia commons
The Sillapadikaram was written by a Jain monk, Illango Adigal, and Sattanar, uses the sequel to question Jainism. It is almost a political battle between two new religions competing for a place in a predominantly Hindu society. Parts of Manimegalai even go to the extent of opening ridiculing Jain practices and beliefs.
Critics of Tamil literature have stated that while the Tamil epics have great poetic significance, they are inferior to other world epics when it comes to clearly portraying religious affiliations. In fact, they refer to the newer religions with an infant's perspective. Some scholars have found that Sillapadikaram has more ethical substance than its sequel, but in and of itself, despite being written by a Jain monk, reads like Hindu poetry (Subhramanya Aiyar, 1906).
Keywords: Manimegalai, Sillapadikaram, Tamil Epic, Sattanar, Ilango Adigal, Chola kingdom, Sangam Age, Buddhism
The Covid-19 pandemic could act as an inflection point to shift India's growth model from being consumption driven to investments-led. In its Ecoscope report, Motilal Oswal Financial Services, said: "With Covid-19 hurting India's 'Household' (HH) and 'Government' sectors adversely, the continuity of strong consumption growth is in question."
"On the contrary, with listed companies' financial positions improving and an uptick in household investments in the Real Estate sector (called physical savings), the narrative of investment-led recovery is gaining momentum." The report prescribed that various economic participants - households, governments, listed companies, and unlisted corporates -- to increase their fixed asset investments in the immediate future based on their financial position.
The Covid-19 pandemic could act as an inflection point to shift India's growth model from being consumption driven to investments-led. | Photo by Fusion Medical Animation on Unsplash
At present, the listed and unlisted corporate sector accounts for only about half of total investments in India. The 'HH' sector including unincorporated enterprises accounts for 35-40 per cent in India's investments, while the remaining 12-13 per cent is contributed by centre and states governments. Besides, the report cited that demand environment is expected to remain subdued due to weak financial position of 'HH' and government sector.
"Despite household investments picking up strongly in 2HFY21, given that Indian households bore the maximum brunt of Covid-led losses in CY20 (and CY21), we believe household spending would remain subdued over the next few years." It further pointed out that unless 'HH', 'Unlisted Corporate', and government sectors can improve their financial positions -- leading to a demand uptick -- a strong revival in investments seems challenging. (IANS/ MBI)
Keywords: India, covid, pandemic, growth, household, government, investment
SpaceX and Tesla CEO Elon Musk has said that next time the Dragon spacecraft will have food warmer and free WiFi. Taking to Twitter, the crew of Inspiration4 shared a checklist of things they have been enjoying while orbiting safely around the Earth.
"Can't believe we're eating cold pizza in space. It's extraordinary!" Inspiration4 tweeted. In response, Musk apologised for the cold food, saying: "Sorry, it was cold! Dragon will have food warmer and free WiFi next time."
Inspiration4 Crew | Wikimedia Commons
After lifting off for space, SpaceX's Inspiration4, the first all-civilian crew, is healthy, happy and doing well in the orbit, the company said recently. The mission lifted off at 8.02 p.m. (EDT) on Wednesday (5.30 am IST on Thursday) aboard SpaceX's Falcon 9 rocket and Dragon spacecraft from the historic Launch Complex 39 in NASA's Kennedy Space Center in Florida.
It is commanded by tech entrepreneur Jared Isaacman who has been joined by medical officer Haley Arceneaux, a pediatric cancer survivor; Mission Specialist Chris Sembroski, an Air Force veteran and aerospace data engineer; and Mission Pilot Sian Proctor, a geoscientist, entrepreneur and trained pilot. (IANS/ MBI)
Keywords: Elon Musk, SpaceX, Inspiration4, Dragon, Wifi, food