Thursday January 17, 2019

Poor Sleep May Signal The Risk of Alzheimer’s in Elderly

For the study, the team studied 119 people aged 60 or older among which almost 80 per cent were cognitively normal and the remainder were very mildly impaired

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alzheimer's, cholesterol
Poor sleep can predict Alzheimer's Risk in elderly. Pixabay

Poor sleep quality may signal the risk of Alzheimer’s disease in older adults, a study suggests.

People with Alzheimer’s tend to wake up tired and their nights become even less refreshing as memory loss and other symptoms worsen.

However, the reason was not fully understood.

The study, led by the Washington University in St. Louis found that older adults who sleep poorly or have less slow-wave sleep — deep sleep needed to consolidate memories and wake up feeling refreshed — have higher levels of tau — a toxic brain protein.

Tau has also been linked to brain damage and cognitive decline.

“Measuring how people sleep may be a non-invasive way to screen for Alzheimer’s disease before or just as people begin to develop problems with memory and thinking,” said lead author Brendan Lucey, Assistant Professor from the varsity.

"The question for us now is not how to eliminate cholesterol from the brain, but about how to control cholesterol's role in Alzheimer's disease through the regulation of its interaction with amyloid-beta," Vendruscolo said.
In Alzheimer’s disease, patients start losing memory, Pixabay

Moreover, the findings, published in the journal Science Translational Medicine, showed that it was not the total amount of sleep that was linked to tau, but the slow-wave sleep, which reflects quality of sleep.

The people with increased tau pathology were actually sleeping more at night and napping more in the day, but they weren’t getting as good quality sleep.

“What’s interesting is that we saw this inverse relationship between decreased slow-wave sleep and more tau protein in people who were either cognitively normal or very mildly impaired, meaning that reduced slow-wave activity may be a marker for the transition between normal and impaired,” Lucey added.

Also Read- Tesla To Retire Lowest-Range Versions of its Model S, X Vehicles

For the study, the team studied 119 people aged 60 or older among which almost 80 per cent were cognitively normal and the remainder were very mildly impaired.

Up to two decades before Alzheimer’s symptoms of memory loss and confusion appear, amyloid beta protein begins to collect into plaques in the brain. Tangles of tau appear later, followed by decline of key brain areas. Only then do people start showing unmistakable signs of cognitive decline.

The challenge is finding people on track to develop Alzheimer’s before such brain changes undermine their ability to think clearly. For that, sleep may be a handy marker, the researchers said. (IANS)

Next Story

Elderly And Conservatives Shared More Fake News On Facebook in 2016

The Massachusetts Institute of Technology's Deb Roy, a former Twitter chief media scientist, said the problem is that the American news diet is "full of balkanized narratives"

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Facebook, Fake News
A sign is shown at Facebook headquarters in Menlo Park, Calif. VOA

People over 65 and ultraconservatives shared about seven times more fake information masquerading as news on Facebook than younger adults, moderates and super liberals during the 2016 election season, a new study found.

The first major study to look at who is sharing links from debunked sites found that not many people were doing it. On average, only 8.5 percent of those studied — about 1 person out of 12 — shared false information during the 2016 campaign, according to the study in Wednesday’s issue of the journal Science Advances. But those doing it tended to be older and more conservative.

“For something to be viral, you’ve got to know who shares it,” said study co-author Jonathan Nagler, a politics professor and co-director of the Social Media and Political Participation Lab at New York University. “Wow, old people are much more likely than young people to do this.”

Battling back

Facebook and other social media companies were caught off guard in 2016 when Russian agents exploited their platforms to meddle with the U.S. presidential election by spreading fake news, impersonating Americans and running targeted advertisements to try to sway votes. Since then, the companies have thrown millions of dollars and thousands of people into fighting false information.

Facebook, fake news
This Nov. 1, 2017, photo shows prints of some of the Facebook ads linked to a Russian effort to disrupt the American political process and stir up tensions around divisive social issues, released by members of the U.S. House Intelligence Committee, in Washington. According to a study published Jan. 9, 2019, in Science Advances, people over 65 and conservatives shared far more false information in 2016 on Facebook than others. VOA

Researchers at Princeton University and NYU in 2016 interviewed 2,711 people who used Facebook. Of those, nearly half agreed to share all their postings with the professors.

The researchers used three different lists of false information sites — one compiled by BuzzFeed and two others from academic research teams — and counted how often people shared from those sites. Then to double check, they looked at 897 specific articles that had been found false by fact checkers and saw how often those were spread.

All those lists showed similar trends.

When other demographic factors and overall posting tendencies are factored in, the average person older than 65 shared seven times more false information than those between 18 and 29. The seniors shared more than twice as many fake stories as people between 45 and 64 and more than three times that of people in the 30-to-44-year-old range, said lead study author Andrew Guess, a politics professor at Princeton.

The simplest theory for why older people share more false information is a lack of “digital literacy,” said study co-author Joshua Tucker, also co-director of the NYU social media political lab. Senior citizens may not tell truth from lies on social networks as easily as others, the researchers said.

Facebook, Fake News
A user gets ready to launch Facebook on an iPhone, in North Andover, Mass., June 19, 2017. Facebook has made changes to fight false information, including de-emphasizing proven false stories in people’s feeds so others are less likely to see them. VOA

Signaling identity

Harvard public policy and communication professor Matthew Baum, who was not part of the study but praised it, said he thought sharing false information was “less about beliefs in the facts of a story than about signaling one’s partisan identity.” That’s why efforts to correct fakery don’t really change attitudes and one reason why few people share false information, he said.

When other demographics and posting practices are factored in, people who called themselves very conservative shared the most false information, a bit more than those who identified themselves as conservative. The very conservatives shared misinformation 6.8 times more often than the very liberals and 6.7 times more than moderates. People who called themselves liberals essentially shared no fake stories, Guess said.

Nagler said he was not surprised that conservatives in 2016 shared more fake information, but he and his colleagues said that did not necessarily mean that conservatives are by nature more gullible when it comes to false stories. It could simply reflect that there was much more pro-Donald Trump and anti-Hillary Clinton false information in circulation in 2016 that it drove the numbers for sharing, they said.

However, Baum said in an email that conservatives post more false information because they tend to be more extreme, with less ideological variation than their liberal counterparts and they take their lead from Trump, who “advocates, supports, shares and produces fake news/misinformation on a regular basis.”

Facebook, social media
Silhouettes of laptop users are seen next to a screen projection of Facebook logo in this illustration. VOA

The researchers looked at differences in gender, race and income but could not find any statistically significant differences in sharing of false information.

Improvements

After much criticism, Facebook made changes to fight false information, including de-emphasizing proven false stories in people’s feeds so others were less likely to see them. It seems to be working, Guess said. Facebook officials declined to comment.

Also Read: EU Authorities Direct Tech Giants To Submit Reports Regarding ‘Fake News’

“I think if we were to run this study again, we might not get the same results,” Guess said.

The Massachusetts Institute of Technology’s Deb Roy, a former Twitter chief media scientist, said the problem is that the American news diet is “full of balkanized narratives” with people seeking information that they agree with and calling true news that they don’t agree with fake.

“What a mess,” Roy said. (VOA)