Friday, August 7, 2020
Home Life Style Health & Fitness It is Now Possible to Reverse Memory Loss Caused by Alzheimer's, Says...

It is Now Possible to Reverse Memory Loss Caused by Alzheimer’s, Says Study

Future studies will focus on developing compounds that penetrate the brain more effectively and are thus longer-lasting, the researchers said

Researchers have developed a novel approach that may one day make it possible to reverse memory loss, caused by Alzheimer’s disease.

The team, led by University at Buffalo scientists, found that by focusing on gene changes caused by influences other than DNA sequences — called epigenetics — it was possible to reverse memory decline in an animal model of Alzheimer’s.

“We have not only identified the epigenetic factors that contribute to the memory loss, but we also found ways to temporarily reverse them in an animal model of Alzheimer’s,” said Zhen Yan, Professor at University at Buffalo in the US.

The research, published in the journal Brain, was conducted on mouse models carrying gene mutations for familial Alzheimer’s — where more than one member of a family has the disease — and on post-mortem brain tissues from Alzheimer’s patients.

alzheimer's, cholesterol
Poor sleep can predict Alzheimer’s Risk in elderly. Pixabay

Alzheimer’s is caused from both genetic and environmental risk factors, such as ageing, which combine to result in epigenetic changes, leading to gene expression changes, but little is known about how that occurs.

The epigenetic changes in Alzheimer’s happen primarily in the later stages, when patients are unable to retain recently learned information and exhibit the most dramatic cognitive decline, Yan said.

A key reason for the cognitive decline is the loss of glutamate receptors, which are critical to learning and short-term memory.

The researchers found that the loss of glutamate receptors is the result of an epigenetic process known as repressive histone modification, which is elevated in Alzheimer’s.

“Our study not only reveals the correlation between epigenetic changes and Alzheimer’s, we also found we can correct the cognitive dysfunction by targeting the epigenetic enzymes to restore glutamate receptors,” Yan said.

A lady suffering from Alzheimer’s. Flickr

The Alzheimer’s animals were injected three times with compounds designed to inhibit the enzyme that controls repressive histone modification.

In animals who received the enzyme inhibitor the cognitive function restored and was confirmed through evaluations of recognition memory, spatial memory and working memory.

Also Read- Facebook Announces to Discontinue its ‘Moments’ App Soon

The improvements lasted for one week. Future studies will focus on developing compounds that penetrate the brain more effectively and are thus longer-lasting, the researchers said. (IANS)

STAY CONNECTED

18,959FansLike
362FollowersFollow
1,780FollowersFollow

Most Popular

Cybercriminals Prefer Misuse of Authentic Software During Attacks, Says Report

Cybercriminals widely use software developed for normal user activity, administrative tasks, and system diagnostics to avoid getting caught quickly after carrying out their attacks,...

Puerperal Period Fitness For New Mothers

Exercise, along with a balanced diet, is an essential part of a healthy lifestyle. Light to moderate physical activity is safe and beneficial for...

Rehabilitation Of World Heritage Site In Mali

The UN's culture organization UNESCO will support a three-year project in African country Mali's Bandiagara that aims to rehabilitate damaged architectural heritage, notably housing,...

People Who Experience Dizziness on Standing Up May be at Higher Risk of Dementia

Researchers have found that people who feel dizzy or lightheaded when they stand up may have an increased risk of developing dementia. The condition, called...

Major Goal is to Identify Planets that Could Support Life: NASA

As scientists search for signs of life on planets outside our solar system, astronomers using NASA's Hubble Space Telescope have detected Earth's own brand...

Need to Adapt to Changing Customer Behaviour: McDonald’s

By Siddhi Jain As India moves forward in the Unlock phases, there is a need to adapt to changing customer behaviour and align business operations...

Vitamin D, Calcium Consumption Twice a Day may Reduce Chances of Getting Vertigo Again

Researchers have revealed that taking vitamin D and calcium twice a day may reduce your chances of getting vertigo again - a sudden internal...

Stock Up Your Monsoon Pantry With These Common Ingredients

By Puja Gupta The monsoon season is possibly every Indians favourite season! Well it is certainly infamous for one's cravings for all-things-fried, along with a...

Recent Comments