Tuesday, January 26, 2021
Home Life Style Health & Fitness Researchers Find Potential New Drug Candidate Against Enterovirus

Researchers Find Potential New Drug Candidate Against Enterovirus

Enterovirus 71 is a common cause of hand, foot and mouth disease in infants and young children

Some good news in the search for antiviral drugs for hard-to-treat diseases as researchers have identified a potential new drug candidate against enterovirus 71, a common cause of hand, foot and mouth disease in infants and young children.

The compound is a small molecule that binds to RNA, the virus’s genetic material, and changes its 3-D shape in a way that stops the virus from multiplying without harming its human host.

Follow NewsGram on Facebook to stay updated.

There are currently no USFDA-approved drugs or vaccines for enterovirus 71, which affects hundreds of thousands of children each year, particularly in Southeast Asia.

While most people get better within 7 to 10 days after suffering little more than a fever and rash, severe cases can cause brain inflammation, paralysis and even death.

According to the study, published in the journal Nature Communications, this work could pave the way for new treatments for other viral infections as well.

Researchers find potential drug for dangerous enterovirus
While most people get better within 7 to 10 days after suffering little more than a fever and rash, severe cases can cause brain inflammation, paralysis and even death. Unsplash

“For diseases that don’t have good treatments, maybe the problem is we’ve been targeting the wrong thing,” said study co-author Amanda Hargrove from Duke University in the US.

Instead of targeting proteins, Hargrove and others are looking for small molecules that target RNA, which most drug discovery programmes have overlooked.

For the current study, Hargrove and colleagues screened a library of some 30 small molecules, looking for ones that bind tightly to the bulge and not other sites in the virus’s RNA.

The RNA is a wiggly molecule; when it binds to other molecules such as host proteins or small molecule drugs it takes on different 3-D shapes.

Want to read more in Hindi? Checkout: भारत ने स्वदेशी ड्रोन ‘अभ्यास’ का किया सफल परीक्षण

The researchers identified one molecule, dubbed DMA-135, that enters infected human cells and attaches itself to the surface of the bulge, creating a kink in this region.

Researchers find potential drug for dangerous enterovirus
The researchers were able to use the molecule to stop the virus from building up inside human cell cultures in the lab, with bigger effects at higher doses. (Representational Image). Unsplash

This shape change, in turn, opens access to another molecule — a human repressor protein that blocks the “reading out” of the virus’s genetic instructions, stopping viral growth in its tracks.

Also Read: Stroke Patients With Covid-19 Show Increased Inflammation, Death Rate: Researchers

In an experiment, the researchers were able to use the molecule to stop the virus from building up inside human cell cultures in the lab, with bigger effects at higher doses.

The authors said that it would take at least five years to move any new drug for hand, foot and mouth disease from the lab to medicine cabinets.

“Before their small molecule could reach patients, the next step is to make sure it’s safe and effective in mice,” the authors wrote. (IANS)

STAY CONNECTED

19,120FansLike
362FollowersFollow
1,773FollowersFollow

Most Popular

High Omega-3 Levels Reduce The Death Risk In Covid

People with higher omega-3 levels in their blood may have a reduced risk of death from Covid-19 infection, a new study suggests. The findings, published...

People Hesitant To Visit The Emergency In USA For Children

Nearly one in four families in the USA had said that they would be unlikely to bring their child to the emergency ward if...

UNEP Says There Is An Increase In Climate Litigations

Climate litigation cases have spiked in recent years, making the courtroom increasingly relevant to efforts to address climate change around the world, an UN...

Study Links Light Pollution And Preterm Birth

Light pollution, based on a direct measure of skyglow, could increase the likelihood of preterm birth, a new study suggests. The study, published in the...

A Farmer Protest Timeline: How Things Turned Violent In Delhi On R-Day

Farmers, who were seen as friendly and peaceful for more than 60 days as they waited for the government to accept their terms, suddenly...

Happy Childhood May Lower Drug Risk Among Teens

If your teenage child has memories of a happy childhood, they are less likely to indulge in drinking or substance abuse and enjoy learning,...

Priyanka Chopra: Its Enlightening To Understand The Importance Of Women In Leadership

Actress Priyanka Chopra Jonas is celebrating the women who helped in drafting the Indian Constitution and says it has been enlightening to understand the...

72nd Republic Day: Time For A Patriotic Musical Rewind

As India celebrates 72nd Republic Day on Tuesday, it is time for a musical rewind of Republic Day songs. There are countless classics that spring...

Recent Comments