Monday September 23, 2019

A Potential Treatment For Polycystic Kidney Disease

Researchers have found a potential treatment for polycystic kidney disease, a genetic disorder that causes the kidneys to swell with multiple cysts

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Kidney, Polycystic, Disease, Treatment
Nature Communications shows an approximately 50 per cent reduction in kidney size in afflicted mice following treatment. Pixabay

Researchers have found a potential treatment for polycystic kidney disease, a genetic disorder that causes the kidneys to swell with multiple cysts and can eventually lead to organ failure.

The study published in the journal Nature Communications shows an approximately 50 per cent reduction in kidney size in afflicted mice following treatment.

The drug is now in early clinical trials on human subjects, the researchers said.

Autosomal dominant polycystic kidney disease (ADPKD) affects about 12 million people worldwide, with half developing end-stage kidney disease by the age of 60, according to the study.

Kidney, Polycystic, Disease, Treatment
A man with Kidney Stones suffering from the typical symptom – pain in the sides that radiates down to the groin. Wikimedia Commons

“Once the kidneys have failed, the only options for survival are dialysis or a kidney transplant, a large percentage of ADPKD patients on dialysis die each year while waiting for a donated kidney,” said Indian origin researcher and study senior author Vishal Patel, Associate Professor at the University of Texas Southwestern Medical Centre.

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According to the study, the new treatment showed no evidence of toxicity in animals or human cell tests. It is preferentially delivered to kidneys rather than the liver after being administered.

“We earlier showed that levels of a tiny RNA fragment called microRNA-17 are increased in models of ADPKD.

“MicroRNA-17 interferes with the normal function of other, beneficial RNAs, causing kidney cysts to grow. RGLS4326, as the new drug is called in development, works by blocking the harmful microRNA-17,” Patel added. (IANS)

Next Story

Here’s What You Can Do To Undo Damage From Prolonged Sitting

These days prolonged sitting on office chairs for long hours, leads to a sedentary lifestyle our bodies were not designed for

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long sitting hours, prolonged sitting, damage, exercise, treatment
Regular jogging was found to be the best type of exercise. Pixabay

After millions of years of physical evolution, modern humans have a body millions died for — quite literally. However, these days prolonged sitting on office chairs for long hours, leads to a sedentary lifestyle our bodies were not designed for.

IANSlife asks a fitness trainer why sitting in the office for too long is dangerous for your body and how one can undo this damage.

“There are three parts to achieve good health — mental wellness, balanced diet and physical movement. Most of us often struggle with the last — physical movement,” says Shivoham, a fitness trainer and brand ambassador at Avvatar Whey Protein.

“Millennials and Gen-Z are accumulating calories, suffering from weak bones, cardiovascular problems and diabetes more than ever before due to long sitting hours.”

For office-goers, Shivoham recommends a minimum of 20 minutes of daily exercise.

“It doesn’t have to be an elaborate work-out with fancy equipment. One just needs to find out what works best for them.”

long sitting hours, damage, exercise, treatment, prolonged sitting
For office-goers, Shivoham recommends a minimum of 20 minutes of daily exercise. Pixabay

Shivoham’s top tips:

*If you go to work via public transport, try to include a walk to your stop.

*Simple tricks like multiple trips to a water cooler to quench thirst can help you increase your steps and thereby exercising your body.

*Regular stretching and flexing can help one keep their joints and muscles in a healthy condition.

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*Ditch chairs sometimes and sit on a swiss ball as it helps in building a strong core.

*Use a standing bench once in a while to keep up the leg movement.

*Try and sit in an Asian squat position to keep your joints in motion.

The fitness guru urges people to be watchful of their posture while sitting in an office chair. Sitting upright and avoiding a sluggish position is what he advises people who have to sit in the office all day. (IANS)