Wednesday January 29, 2020

A Potential Treatment For Polycystic Kidney Disease

Researchers have found a potential treatment for polycystic kidney disease, a genetic disorder that causes the kidneys to swell with multiple cysts

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Kidney, Polycystic, Disease, Treatment
Nature Communications shows an approximately 50 per cent reduction in kidney size in afflicted mice following treatment. Pixabay

Researchers have found a potential treatment for polycystic kidney disease, a genetic disorder that causes the kidneys to swell with multiple cysts and can eventually lead to organ failure.

The study published in the journal Nature Communications shows an approximately 50 per cent reduction in kidney size in afflicted mice following treatment.

The drug is now in early clinical trials on human subjects, the researchers said.

Autosomal dominant polycystic kidney disease (ADPKD) affects about 12 million people worldwide, with half developing end-stage kidney disease by the age of 60, according to the study.

Kidney, Polycystic, Disease, Treatment
A man with Kidney Stones suffering from the typical symptom – pain in the sides that radiates down to the groin. Wikimedia Commons

“Once the kidneys have failed, the only options for survival are dialysis or a kidney transplant, a large percentage of ADPKD patients on dialysis die each year while waiting for a donated kidney,” said Indian origin researcher and study senior author Vishal Patel, Associate Professor at the University of Texas Southwestern Medical Centre.

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According to the study, the new treatment showed no evidence of toxicity in animals or human cell tests. It is preferentially delivered to kidneys rather than the liver after being administered.

“We earlier showed that levels of a tiny RNA fragment called microRNA-17 are increased in models of ADPKD.

“MicroRNA-17 interferes with the normal function of other, beneficial RNAs, causing kidney cysts to grow. RGLS4326, as the new drug is called in development, works by blocking the harmful microRNA-17,” Patel added. (IANS)

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Weight-Loss Surgery May Help in Reducing Risk of Colorectal Cancer: Study

This meta analysis was conducted to investigate the effect of bariatric surgery on the risk of developing colorectal cancer in obese individuals

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Cancer
Obesity increases the risk of many medical conditions, including Type 2 diabetes, cardiovascular diseases, and most cancers, including colorectal cancer. Pixabay

Researchers have found found that weight-loss surgery may reduce by over one third the risk of developing colorectal cancer.

The study, published in the British Journal of Surgery (BJS), showed that patients who underwent bariatric surgery had a greater than 35 per cent reduction in the risk of developing colorectal cancer compared with obese individuals who had no surgery.

“Day by day, the scientific community is continuing to uncover the benefits of weight- loss surgery, and this paper affirms this,” said study lead author Sulaiman Almazeedi from Jaber Al-Ahmed Hospital in Kuwait.

“Obesity today remains one of the most preventable causes of morbid disease and early death, and despite the controversy, we believe weight-loss surgery can be an important tool in tackling this epidemic,” Almazeedi added.

Obesity increases the risk of many medical conditions, including Type 2 diabetes, cardiovascular diseases, and most cancers, including colorectal cancer.

According to the researchers, the BJS analysis, which included seven studies with a total of 12,13,727 patients and an average follow-up of seven years, was conducted because individual studies have presented conflicting results.

Cancer
Researchers have found found that weight-loss surgery may reduce by over one third the risk of developing colorectal cancer. Pixabay

This meta analysis was conducted to investigate the effect of bariatric surgery on the risk of developing colorectal cancer in obese individuals.

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The overall risk of developing colorectal cancer was three in 1,000 in patients with obesity who underwent weight-loss surgery, compared with four in 1,000 in those who did not, the study said. (IANS)