Sunday September 23, 2018

Progression of Parkinson disease could be slowed with exercise

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Progression of Parkinson disease could be slowed with exercise
Progression of Parkinson disease could be slowed with exercise. wikimedia commons
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New York, Dec 23, 2017: Exercise can stop accumulation of a harmful protein which is believed to play a central role in the brain cell death associated with Parkinson’s disease, new research has found.

Engaging in exercise on a running wheel can stop the accumulation of the neuronal protein alpha-synuclein in brain cells, showed the study published in the journal PLOS ONE.

Parkinson’s disease causes progressive loss of muscle control, trembling, stiffness, slowness and impaired balance.

“Our experiments show that exercise can get to the heart of the problem in Parkinson’s disease,” said one of the researchers Curt Freed, Professor at University of Colorado Anschutz Medical Campus in the US.

“People with Parkinson’s who exercise are likely able to keep their brain cells from dying,” Freed added.

The experiment was conducted in a mouse model of Parkinson’s, and the mice in the study, like humans, started to get Parkinson’s symptoms in mid-life. At 12 months of age, running wheels were put in their cages.

The researcehrs found that in the running mice, exercise increased brain and muscle expression of a key protective gene called DJ-1, compared to control transgenic animals which had locked running wheels.

Those rare humans born with a mutation in their DJ-1 gene are guaranteed to get severe Parkinson’s at a relatively young age.

The researchers tested mice that were missing the DJ-1 gene and discovered that their ability to run had severely declined, suggesting that the DJ-1 protein is required for normal movement.

“Our results indicate that exercise may slow the progression of Parkinson’s disease by turning on the protective gene DJ-1 and thereby preventing abnormal protein accumulation in brain,” Freed said.

He explained that his animal experiments had very real implications for humans.

Parkinson’s is a disease caused by the death of brain cells that make a critical chemical called dopamine. Without dopamine, voluntary movement is impossible. (IANS)

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Learn How Muscles Help Burn Fat During Exercise

Burning fat is likely to impact multiple aspects of metabolic health related to diabetes, heart disease and other conditions

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Further research revealed that BAIBA levels rise during exercise and are inversely associated with metabolic risk factors. Pixabay

Ever thought what helps burn fat across your body while exercising? According to a study, it is a molecule in our muscles that is produced during exercise and contributes to the beneficial effects of exercise on metabolism.

“Our finding bolsters the underlying notion that signals generated in exercising muscle are released into the circulation and influence other tissues such as fat cells and liver,” said senior author Robert Gerszten at Massachusetts General Hospital, the primary teaching hospital of Harvard Medical School.

The researchers knew that a protein called PGC-1? regulates metabolic genes in muscle and contributes to the response of muscle to exercise.

But how this protein conveys signals to other tissues was unclear so far.

Gerszten and his colleagues forced the expression of PGC-1? in muscle cells and then looked for metabolites that were secreted from the cells.

Exercise
BAIBA also decreased weight gain and helped balance blood sugar levels in mice, said the study published in the journal Cell Metabolism. Pixabay

They identified ?-aminoisobutyric acid (BAIBA) as one such metabolite and found that it increased fat cells’ expression of genes that are involved with burning calories.

BAIBA also decreased weight gain and helped balance blood sugar levels in mice, said the study published in the journal Cell Metabolism.

Further research revealed that BAIBA levels rise during exercise and are inversely associated with metabolic risk factors.

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“The findings suggest that BAIBA may contribute to exercise-induced protection from metabolic diseases. Manipulating BAIBA – or enzymes that generate BAIBA – may have therapeutic potential,” said Gerszten.

Burning fat is likely to impact multiple aspects of metabolic health related to diabetes, heart disease and other conditions, the study concluded.  (IANS)

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