Thursday November 15, 2018

Progression of Parkinson disease could be slowed with exercise

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Progression of Parkinson disease could be slowed with exercise
Progression of Parkinson disease could be slowed with exercise. wikimedia commons
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New York, Dec 23, 2017: Exercise can stop accumulation of a harmful protein which is believed to play a central role in the brain cell death associated with Parkinson’s disease, new research has found.

Engaging in exercise on a running wheel can stop the accumulation of the neuronal protein alpha-synuclein in brain cells, showed the study published in the journal PLOS ONE.

Parkinson’s disease causes progressive loss of muscle control, trembling, stiffness, slowness and impaired balance.

“Our experiments show that exercise can get to the heart of the problem in Parkinson’s disease,” said one of the researchers Curt Freed, Professor at University of Colorado Anschutz Medical Campus in the US.

“People with Parkinson’s who exercise are likely able to keep their brain cells from dying,” Freed added.

The experiment was conducted in a mouse model of Parkinson’s, and the mice in the study, like humans, started to get Parkinson’s symptoms in mid-life. At 12 months of age, running wheels were put in their cages.

The researcehrs found that in the running mice, exercise increased brain and muscle expression of a key protective gene called DJ-1, compared to control transgenic animals which had locked running wheels.

Those rare humans born with a mutation in their DJ-1 gene are guaranteed to get severe Parkinson’s at a relatively young age.

The researchers tested mice that were missing the DJ-1 gene and discovered that their ability to run had severely declined, suggesting that the DJ-1 protein is required for normal movement.

“Our results indicate that exercise may slow the progression of Parkinson’s disease by turning on the protective gene DJ-1 and thereby preventing abnormal protein accumulation in brain,” Freed said.

He explained that his animal experiments had very real implications for humans.

Parkinson’s is a disease caused by the death of brain cells that make a critical chemical called dopamine. Without dopamine, voluntary movement is impossible. (IANS)

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Child’s Health Also Impacted By The Father’s Exercise Routine

The researchers also found that exercise helped even with a poor diet.

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Infants, baby
Fathers’ Exercise Impacts the Health of Their Children. Pixabay

Many people know that a woman’s health, including her diet and exercise habits, can impact the health of her baby even before she gets pregnant. But, until recently, little was known about a father’s diet and exercise choices.

Matthew Hurt is teaching his young sons how to hit a baseball. He wants them to enjoy sports and exercising.

“I want it to be just natural for them. I don’t want it to be a chore. I want them to just want to go outside, want to be active and enjoy life to its fullest.”

Impact of exercise

A study at Ohio State University Wexner Medical Center looked at the impact of fathers’ exercise habits on their offspring.

Kristin Stanford is a member of Ohio State’s Diabetes and Metabolism Research Center. She co-led the study. The results showed that even moderate exercise before a baby was conceived “resulted in an improved metabolic health in their adult offspring. Essentially, it improved their glucose metabolism, decreased body weight and increased their insulin sensitivity.”

The World Health Organization says 1 in 4 adults worldwide are dangerously inactive. That increases the risk of obesity, high blood pressure, heart disease, stroke, cancer and diabetes.

Child, baby, father
A man twirls a young baby on a waterfront park as downtown Seattle disappears in a smoky haze behind, Aug. 19, 2018. VOA

Inactivity also has social and economic consequences.

The research at Ohio State was done in mice. More work needs to be done to see if it applies to people as well.

“The idea would be that if you have a dad who wants to have a baby, if they would exercise maybe just a month prior to conception, that would have a really dramatic effect on their child’s life.”

Child, baby, father
Exposure to smoking in childhood thickens arteries’ walls which, in turn, ups the risks of heart attack and stroke. Pixabay

Poor diet? Just exercise

The researchers also found that exercise helped even with a poor diet. Sedentary mice fed a high fat diet passed along negative health issues like obesity and insulin resistance, but those effects were completely reversed by exercise.

Also Read: Top Health Habits Which Parents Can Teach Their Children

“A high-fat diet, even mild high-fat diet, in this case it was only three weeks, changes the profile, but exercise kind of restored it back to normal.”

More work needs to be done to see if the same applies to humans. But in the animal studies, exercise for the male mouse was key to the health of his offspring.

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