Tuesday February 25, 2020

Know Which Medication Can Help By Protecting You From Familial Breast Cancer

Earlier Austrian studies have given strong indications that Denosumab may be effective against breast cancer, experts said

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Up to now the only preventative measure against both cancers has been surgical removal of the affected breast tissue or the ovaries. Pixabay

Breast cancer passed down in families may be preventable by the medication Denosumab, which is undergoing a five-year study in Austria.

The Austrian Breast and Colorectal Cancer Study Group is leading the work as it examines the drug’s effectiveness on 2,950 patients with a hereditary disposition to this particular form of cancer, according to an Austria Press Agency report.

Speaking at a press conference on Thursday, Professor Christian Singer from the Vienna General Hospital said the study will also examine the effects of Denosumab on healthy women who have a mutation in the BRCA1 gene, reports Xinhua news agency.

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enosumab is known as a monoclonal antibody and has been used in particular to treat osteoporosis, due to its capacity to prevent the development of cells that break down bone. Pixabay

These women have a 1.8 per cent chance of developing breast cancer each year, or about an 80 per cent chance during their lifetime. In addition, they have a 50 per cent chance of developing ovarian cancer.

Up to now the only preventative measure against both cancers has been surgical removal of the affected breast tissue or the ovaries.

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The Austrian Breast and Colorectal Cancer Study Group is leading the work as it examines the drug’s effectiveness on 2,950 patients with a hereditary disposition to this particular form of cancer, according to an Austria Press Agency report. Pixabay

The participants in the drug trial will receive either a Denosumab injection or a placebo every six months, Singer said.

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Denosumab is known as a monoclonal antibody and has been used in particular to treat osteoporosis, due to its capacity to prevent the development of cells that break down bone.

Earlier Austrian studies have given strong indications that Denosumab may be effective against breast cancer, experts said. (IANS)

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Know About This Simple Blood Test That Can Identify Heart Diseases

Simple blood test can help reduce heart disease deaths

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Blood test
Researchers have revealed how a simple blood test could be used to help identify cardiovascular ageing and the risk of heart disease. (Representational Image). Pixabay

Researchers have revealed how a simple blood test could be used to help identify cardiovascular ageing and the risk of heart disease. This is the latest news.

The study, published in the Journal of the American College of Cardiology, reported that higher levels of amyloid-beta in the blood may be a key indicator of cardiovascular disease.

Amyloid-beta is known to be involved in the development of Alzheimer’s disease, yet researchers have now concluded that it may have a key role to play in vascular stiffening, thickening of the arteries, heart failure and heart disease progression.

It is hoped that this research will one day lead to the development of a simple blood test that could be used as a clinical biomarker to identify patients who are most at risk, so that preventative measures can be put in place and death rates reduced.

Blood test
Higher levels of amyloid-beta in the blood may be a key indicator of cardiovascular disease. Pixabay

“Our work has created and put all the pieces of the puzzle together. For the first time, we have provided evidence of the involvement of amyloid-beta in early and later stages of cardiovascular disease,” said study researcher Konstantinos Stellos from Newcastle University in the UK.

For the findings, the research team analysed blood samples from more than 6,600 patients from multiple cohort studies in nine countries, and found that patients could be divided into high and low risk categories of heart disease based on their amyloid-beta levels.

“What is really exciting is that we were able to reproduce these unexpected, clinically meaningful findings in patients from around the world. In all cases, we observed that amyloid-beta is a biomarker of cardiovascular ageing and of cardiovascular disease prognosis,” Stellos added.

The study proposed the existence of a common link between both conditions, which has not been acknowledged before, and could lead to better patient care. The findings suggest that the higher the level of amyloid-beta in the blood the higher the risk of developing serious heart complications.

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In the future, it is hoped that a simple blood test could be added to the current method of patient screening, known as the GRACE score, which assesses heart attack risk and guides patients’ treatment plans. Using the GRACE score, eight factors are used to predict the risk of heart attack, including age, blood pressure, kidney function and elevated biomarkers. (IANS)