Saturday January 25, 2020

Protein Named ‘Sestrin’ May Help You Cut Flab Without Moving a Muscle

This protein may help cut flab without moving a muscle

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Protein fat
Here comes a protein that can help them cut flab without high-intensity gym. Pixabay

In good news for couch potatoes, here comes a protein that can help them cut flab without high-intensity gym or even a brisk walk around the park. The catch is: It is not yet available as pills but occurs naturally in the body.

Called ‘Sestrin’, the protein might harness the benefits of a good workout without ever moving a muscle, say researchers from University of Michigan.

While studying a class of naturally-occurring protein called Sestrin, they found that it can mimic many of exercise’s effects in flies and mice.

protein workout
The beneficial effects of Sestrin include more than just improved endurance and physical performance. Pixabay

The findings could eventually help scientists combat muscle wasting due to ageing and other causes.

Researchers have previously observed that Sestrin accumulates in muscle following exercise,” said Myungjin Kim, research assistant professor in the Department of Molecular & Integrative Physiology.

Kim, working with professor Jun Hee Lee and a team of researchers wanted to know more about the protein’s apparent link to exercise.

Taking advantage of Drosophila flies’ normal instinct to climb up and out of a test tube, their collaborators from Wayne State University in Detroit developed a kind of fly treadmill.

Using it, the team trained the flies for three weeks and compared the running and flying ability of normal flies with that of flies bred to lack the ability to make ‘Sestrin’.

“Flies can usually run around four to six hours at this point and the normal flies’ abilities improved over that period,” said Lee. “The flies without Sestrin did not improve with exercise”.

What’s more, when they overexpressed Sestrin in the muscles of normal flies, essentially maxing out their Sestrin levels, they found those flies had abilities above and beyond the trained flies, even without exercise.

In fact, flies with overexpressed Sestrin didn’t develop more endurance when exercised.

The beneficial effects of Sestrin include more than just improved endurance.

protein workout
Called ‘Sestrin’, the protein might harness the benefits of a good workout without ever moving a muscle. Pixabay

Mice without Sestrin lacked the improved aerobic capacity, improved respiration and fat burning typically associated with exercise.

“We propose that Sestrin can coordinate these biological activities by turning on or off different metabolic pathways,” Lee said, adding that this kind of combined effect is important for producing exercise’s effects.

Lee also helped another collaborator, Pura Munoz-Cánoves of Pompeu Fabra University in Spain to demonstrate that muscle-specific ‘Sestrin’ can also help prevent atrophy in a muscle that’s immobilized, such as the type that occurs when a limb is in a cast for a long period of time.

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“This independent study again highlights that Sestrin alone is sufficient to produce many benefits of physical movement and exercise,” Lee said.

Could Sestrin supplements be on the horizon? Not quite, said Lee, adding that Sestrins are not small molecules, but “we are working to find small molecule modulators of Sestrin”. (IANS)

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Top Tips to Personalize Your Fitness Routine

Find a personalised exercise routine for your body

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Fitness
With so many options available in the fitness space, finding the one right for you can be a task. Pixabay

With so many options available in the health, lifestyle fitness space, finding the one right for you can be a task.

Amaresh Ojha, CEO and Founder, Gympik shares his top tips.

1. Assess your fitness level- To assess your fitness progress, calculating the number of beats of your resting heart rate (RHR) is a beneficial way. The RHR should reduce as your fitness improves.

To calculate your RHR, place two fingers on your wrist (radial artery), and then count the number of heart beats you feel in a period of 60 seconds. Make sure to count the first beat as ezero’.

More than 101 is unusually high and not good. Between 81 and 100 is high, but acceptable, between 61 and 80 is average and 60 or less is good.

Fitness
Assessing your fitness level can be very helpful. Pixabay

2. Choose what form of exercise works best for you- While any type of physical activity is beneficial for you, different physical activities present different results.

Yoga is a discipline that focuses on breathing methods, meditation, and physical postures. It has a low-impact structure and hence is gentler on the joints. Yoga helps in improving muscle endurance, flexibility and body balance.

Zumba is an amalgamation of both fast and slow dancing, so it works on your whole body, helping you to lose weight and tone every muscle group, predominantly your back and abdominals. It also improves your posture, balance and flexibility. So, if you wish to develop a flamboyant body shape along with enhancing your dance moves, Zumba will be the right choice for you. One concern with this exercise form is that the best result for Zumba comes while working out in groups, so you will have to join a Zumba class to get the best out of this exercise form.

Pilates is largely focused with core strength. It improves muscle tone and strength along with obtaining a leaner look. This exercise form promotes balanced muscle development, flexibility and helps you in gaining a beautiful posture. Hence, the gateway to a graceful personality is through regular Pilates workout. One disadvantage of this type of exercise form is that it misses out on cardio, so it’s not very effective for steady weight loss.

Walking is one of the best exercises that must be an integral part of your fitness schedule. Regular brisk walk can help in preventing heart diseases and managing high blood pressure and type 2 diabetes along with improving the mood. No matter how many hours you spend in the gym, walking is the best way to lose weight and stay healthy. This is one of the exercise forms that can be practised by all.

Cycling is an activity that is gentle on the joints. It burns fat and improves your cardiovascular health. If you wish to increase your stamina and at the same time tone up your muscles, cycling is the best way of doing so. You can easily make it a part of your routine by building it in your day as a means of transport.

Fitness
Consult with your doctor before incorporating a fitness routine in your lifestyle. Pixabay

3. E-Fitness learning platforms can help you analyse the pros and cons of any form of exercise and you can choose the correct type of exercise for yourself once you know the benefits of each type. There are several E-Fitness channels that you can subscribe to and work with a virtual instructor, who will guide you through your fitness journey.

4. Exercise safe and focus on the health concerns. Pre-exercise screening will help you to identify any medical conditions that may put you at a higher risk of enduring a health issue during physical activity. Consult with your doctor before incorporating a fitness routine in your lifestyle. Certain exercises like running on the treadmill, sprinting, heavy weightlifting etc. can prove injurious for heart patients. Similarly, certain breathing exercises in Yoga can prove harmful for asthmatic patients.

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While there are several options available, the most important thing to keep in mind is to choose an exercise that you find fun and can stick to for the long haul. Choose from your preferences and make your exercise time fun. Do you wish to spend time indoors or outdoors? Alone or with friends/people?

If you choose an activity that seems like a burden after some time, you are more likely to abandon a healthy lifestyle. (IANS)