Never miss a story

Get subscribed to our newsletter


×
How different kinds of immune cells, called macrophages, develop in the lungs. Pixabay

A team of Swedish researchers has revealed how different kinds of immune cells, called macrophages, develop in the lungs, and which of them may be behind severe lung diseases, a discovery that may contribute to future treatments for Covid-19, among other diseases. To date, research on the development of human lung macrophages has been limited.

In a new study published in Immunity, researchers at Karolinska Institutet in Sweden used a model to study the development of lung macrophages directly in a living lung. This has been combined with a method to study gene activity in individual cells, RNA sequencing, and thereby discovered how blood monocytes become human lung macrophages.


Follow NewsGram on Instagram to keep yourself updated.

“In our study, we show that classical monocytes migrate into airways and lung tissue and are converted into macrophages that protect the health and function of the lungs,” said Tim Willinger, Associate Professor at the Department of Medicine who led the study.

“We have also identified a special kind of monocyte, HLA-DRhi, which is an intermediate immune cell between a blood monocyte and an airway macrophage.” These HLA-DRhi monocytes can leave the blood circulation and migrate into the lung tissue. Macrophages are immune cells that, among other things, protect the lungs from attacks on lungs.


Research on the development of human lung macrophages. Pixabay

But under certain conditions, lung macrophages can also contribute to severe attacks on lungs, such as chronic obstructive pulmonary disease (COPD) and Covid-19. The non-classical monocytes, however, develop into macrophages in the many blood vessels of the lungs and do not migrate into the lung tissue.

ALSO READ: Wearable Stimulator To Zap Alzheimer Disease

In infection with the novel coronavirus, SARS-COV-2, which causes Covid-19, researchers believe that protective, anti-inflammatory macrophages are replaced by pro-inflammatory lung macrophages from blood monocytes.

“Given their important role in rapid inflammatory responses, our results indicate that future treatments should focus on inflammatory macrophages and monocytes to reduce lung damage and mortality from severe Covid-19,” said Willinger. (IANS)


Popular

Designer Payal Singhal launched her first ever shop in New Delhi at Aza, Ambawatta One, Mehrauli.| Photo by Hannah Morgan on Unsplash (Photo used for representation)

By IANSlife

Designer Payal Singhal launched her first ever shop in New Delhi at Aza, Ambawatta One, Mehrauli. At this new location, she also unveiled "Suroor" her Winter Festive' 2021 collection for Women that stays true to the brand's DNA of deconstructing and reimagining traditional Indian silhouettes for the modern aesthete.

The collection is replete with hybrid lehenga with cut-outs, sharara sets, kaftan kurtas and anarkalis; all enhanced with intricate mukaish, zardozi, gota, nakshi, pitta and mirror work. Statement yokes, the latest take on the House's signature back-tie choli, and a new burst of #PSPrints are also an integral part of the collection. For the first time, Payal has worked with bandhanis developed in Jaipur, but with her inimitable twist - using the technique on tussar instead of silks. (IANS/ MBI)


Keep Reading Show less
Photo by Wikimedia Commons

Today marks the 114th birth anniversary of Harivansh Rai Bachchan, a renowned Indian poet. He is popularly known for his poem ‘Madhushala’.

Today marks the 114th birth anniversary of Harivansh Rai Bachchan, a renowned Indian poet. He is popularly known for his poem ‘Madhushala’.

Early life of Harivansh Rai Bachchan

Keep Reading Show less
unsplash

The new master plan extends from the Ring Road

The Yogi Adityanath government in Uttar Pradesh is setting up industrial corridors along both sides of Lucknow-Faizabad-Gorakhpur four-lane national highway within the 65 km periphery of the Ayodhya Development Authority's (ADA) jurisdiction.

The industry hub, spread over 100 acres, will form part of Ayodhya Master Plan-2031 that is being prepared by the ADA.

According to ADA Vice Chairman Vishal Singh, the master plan is expected to be finalised next month and will be sent for state government's approval.

Follow NewsGram on Facebook to stay updated.

Keep reading... Show less