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Researchers from Duke University in the US, have created a new Cancer-Detecting Tool, which uses tiny circuits made up of DNA to identify Cancer cells by the molecular signatures on their surface.
According to the study published in the Journal of the American Chemical Society, the research team fashioned the simple circuits from interacting strands of synthetic DNA that are tens of thousands of times finer than a human hair.
Unlike the circuits in a computer, these circuits work by attaching to the outside of a cell and analysing it for proteins found in greater numbers on some cell types than others.
If a circuit finds its targets, it labels the cell with a tiny light-up tag.
Because the devices distinguish cell types with higher specificity than previous methods, the researchers hope their work might improve diagnosis, and give cancer therapies better aim.
For the findings, the research team designed a DNA circuit that must latch onto that specific combination of proteins on the same cell to work.
“As a result they’re much less likely to flag the wrong cells,” said study researcher John Reif.
Each basic element of their DNA circuit consists of two DNA strands.
The first DNA strand folds over and partially pairs up with itself to form a hairpin shape.
One end of each hairpin is bound to a second strand of DNA that acts as a lock and tether, folding in such a way to fit a specific cell surface protein like a puzzle piece.
Together these two strands act to verify that that particular protein is present on the cell surface.
To look for cancer, the circuit components are mixed with a person’s cells in the lab.
If any cells are studded with the right combination of proteins, the complete circuit will attach.
Adding a strand of “initiator” DNA then causes one of the hairpins to open, which in turn triggers another in a chain reaction until the last hairpin in the circuit is opened and the cell lights up.
Test runs of the device in test tubes in Reif’s lab showed it can be used to detect leukemia cells and to distinguish them from other types of cancer within a matter of hours, just by the strength of their glow.
The devices can be easily reconfigured to detect different cell surface proteins by replacing the tether strands, the researchers said.
The technology could be used as a screening tool to help rule out cancer, which could mean fewer unnecessary follow-ups, or to develop more targeted cancer treatments with fewer side effects.
In the future, Reif plans for the DNA circuits to release a small molecule that alerts the body’s immune system to attack the cancer cell. (IANS)
Anuja Kapur, Psychologist shares few tips wherein you can assist your child when tough times comes calling:
Every child responds differently to disturbing events: What children feel about a current disaster in their life and how they react to it can come and go in waves. Children can act moody and withdrawn at times, struck with sorrow and fear at other times. There's no absolute "right" or "wrong" way to feel after a traumatic event so make sure not to dictate what your child or how your child should feel and react to the event.
Keywords: Kids, Help, stress, cope, routine, warmth, understanding, encourage, psychology, children
"Chargers power all our most essential electronic devices | Photo by Solen Feyissa on Unsplash
"Chargers power all our most essential electronic devices. With more and more devices, more and more chargers are sold that are not interchangeable or not necessary. We are putting an end to that," the report quoted EU commissioner Thierry Breton as saying.
The Commission also wants to unbundle the sale of chargers from the sale of electronic devices, which it says will improve the consumers' convenience. "With our proposal, European consumers will be able to use a single charger for all their portable electronics - an important step to increase convenience and reduce waste." In addition, the Commission will require manufacturers to provide relevant information about charging performance. (IANS/MBI)
Keywords: Electronic Devices, Chargers, Cable, smartphone, Adapters, Charging Cord
By- Devakinanda Ji
OṀ (AUM)-JII-VI-ṪAAR-DHA-BO'-DHA-KA- BHOO-MYAI-Ṇ—NA-MA-HA
ॐ जीवितार्थबोधकभूम्यै नमः
(Jīviṫa: Life; Ardha: Meanining; Bodhaka: That which teaches)
What is born has to die. Anything that has form and shape has to degrade over time. The question is how one has lived his life or how long he has lived? The vanity toward their bodies, their desire for longevity, and material indulgence the westerns have; you don't see anywhere else on the planet.
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Our scriptures and sacred texts teach us that there are 8.4 million species born and every living being that is born, indeed dies. Human life is the highest species because of awareness and a human has the opportunity to redeem himself or herself in this life with the free will given to them. We have the faculties of action, freewill, and the power of knowledge. These faculties make humans different than all the other animals, which are programmed to eat, procreate and sleep. Our ancient spiritual scientists (sages, rishis, and seers) educated us to think about the temporary nature of our bodies. We take it for granted that we live forever; even as we see people around us dying. Still we live in a delusion, thinking that we won't die and will live happily ever after. But our rishis constantly remind us that we should work towards liberation while living in this body (jēvanmukta).
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Only our sacred texts like the Vedas and Upanishads can answer deep philosophical questions like: what is the purpose of our universe? The reason for our lives? the meaning and purpose of life? You may not find the answers in any other religion. Our philosophy does not stop at going to heaven after death, but discusses very thoroughly karma, rebirth, and liberation. Our Vedas discuss how to get out of the wheel of birth and death (punarapi jananam; punarapi maraṇam). They laid down dharmasūtrās (do's and don'ts) for us to live by. They clearly explain about heaven (if you believe in and desire it) and the journey the jīva (pure spirit) takes after the death of the gross body, based on the results of our actions while alive. Vedas have established the four purushārthās (dharma, artha, kāma and mokṣha) as the goals of life.
Hence, our land is the one which teaches the ends to be striven for by human beings and is 'Jīvitārdhabodhaka Bhūmi'.