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Researchers discover Protein that can help make Vaccinations more effective, also protection from Cancer

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Cancer patient in hospital. Wikimedia

New York, April 8, 2017: Researchers have discovered a protein that could help make vaccinations more effective and also provide protection from other diseases such as cancer.

The researchers purified a protein found on the exterior of bacteria (neisseria meningidis) and used it as an accessory to provide a better vaccination response.

Typically, vaccines can either increase the amount of antibody production or they can stimulate cells (called cytotoxic T cells) to directly kill the offending agent.

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The protein, called PorB, is unique in that it can do both, the researchers said.

The study, published online in the journal Scientific Reports, may lead to greater understanding of how vaccine enhancers work and can best be used.

“This study has wide implications as it could not only be used to help the body identify and fight off bacterial infections, but it could also potentially help the body use its own machinery to fight off other diseases like cancer, HIV, and influenza before they have a chance to establish within the body,” explained corresponding author Lee Wetzler, Professor of Medicine and Microbiology at Boston University School of Medicine (BUSM) in the US.

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In this study, the researchers used two experimental models. The first model was given a vaccination with antigen and mixed PorB, while the second model was given the antigen alone.

The model that received the PorB had an increase in the response to the vaccine antigen, evidenced by an increased number of activated cells in the lymph nodes and a gain in the production of cytotoxic T cells, as compared to the vaccination with the antigen alone.

“Our study deepens the general understanding of how vaccine adjuvants modulate immune responses,” Wetzler said.

“The antigen formulation with PorB triggers a sequence of cellular events at the periphery and in lymphoid tissue that are critical for the establishment of protection to a broad array of infectious diseases, and maybe for other diseases like cancer,” Wetzler added. (IANS)

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Research Reveals, Cancer Patients Are More Likely To Use Marijuana

"Medical marijuana legislation has previously been associated with reduction in hospitalisations related to opioid dependence or abuse, suggesting if patients are in fact substituting marijuana for opioid, this may introduce an opportunity for reducing opioid-related morbidity and mortality,"

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The researchers found significantly increased use of marijuana over time -- likely reflecting increased availability due to legislative changes -- but they found stable rates of opioid use. Pixabay

Many cancer patients use marijuana and its usage has increased, a new study suggests. The findings, published in the journal CANCER, indicate 40.3 per cent cancer patients used marijuana within the past year, compared with 38 per cent of respondents without cancer.

“Prospective clinical trials are needed to quantify the efficacy of marijuana in cancer-specific pain as well as the risk of opioid misuse in this patient population,” said co-author Kathryn Ries Tringale from the University of California, San Diego.

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They found patients with cancer were more likely to use prescription opioids than adults without cancer — 13.9 per cent versus 6.4 per cent. Pixabay

For the study, 826 people with cancer were matched to 1,652 controls.

The researchers found significantly increased use of marijuana over time — likely reflecting increased availability due to legislative changes — but they found stable rates of opioid use.

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“Prospective clinical trials are needed to quantify the efficacy of marijuana in cancer-specific pain as well as the risk of opioid misuse in this patient population,” said co-author Kathryn Ries Tringale from the University of California, San Diego. VOA

They found patients with cancer were more likely to use prescription opioids than adults without cancer — 13.9 per cent versus 6.4 per cent.

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“Medical marijuana legislation has previously been associated with reduction in hospitalisations related to opioid dependence or abuse, suggesting if patients are in fact substituting marijuana for opioid, this may introduce an opportunity for reducing opioid-related morbidity and mortality,” said lead author Jona Hattangadi-Gluth from the varsity. (IANS)