Never miss a story

Get subscribed to our newsletter


×
A fruit fly is seen in a laboratory at the Bar-Ilan University, in Ramat Gan, Israel, May 1, 2018. VOA

Scientists who gave fruit flies a triple drug combination treatment and found that it extended their lives by almost 50% say their work offers clues on how to fight aging in people. Researchers.

The researchers said their aim is not to find the secret of eternal life, but to figure out the mechanism of the aging process to find ways to help people stay healthy for longer.


“We are not trying to cheat death, but help people be healthy and disease-free in their final years,” said Linda Partridge, a professor at University College London’s Institute of Healthy Ageing and the Max Planck Institute for Biology of Ageing who co-led the work.

The three drugs – the mood stabilizer lithium, a cancer treatment called trametinib and an immune regulator called rapamycin – target different cellular processes and had a “quite remarkable” impact on the flies’ lifespans, the scientists said.


The researchers said their aim is not to find the secret of eternal life, but to figure out the mechanism of the aging process to find ways to help people stay healthy for longer. Pixabay

And since the three drugs are all already in use as medical treatments, they are known to be safe to use in people, we have found that a combination drug treatment … may be an effective way to slow down the aging process,” said Jorge Castillo-Quan, who co-led the research.

Partridge said the findings add to growing evidence that so-called polypills — pills that combine low doses of multiple drugs — could one day help prevent age-related diseases.

“This may be possible by combining the drugs we’re investigating with other promising drugs, but there is a long way to go,” she said.

This research adds to previous studies finding that individually, lithium, trametinib and rapamycin can each extend lifespan in fruit flies. That evidence has also been supported by further studies in mice and worms, the scientists said.

Also Read- Eating Red Meat Links to Cancer and Heart Disease, but are the Risks Big Enough to Give Up Burgers and Steak?

In this study, published in Proceedings of the National Academy of Sciences journal, Castillo-Quan’s team gave fruit flies doses of the three drugs separately and in combination.

Each drug individually extended lifespan by an average of 11%, they found, and pairing two drugs extended lifespan by around 30%. But when all three were combined, the fruit flies lived 48% longer than flies that did not get the treatment.

“We found it was quite remarkable that this drug combination enabled them to live 48% longer,” said Castillo-Quan, who now works at Harvard Medical School in the United States.

The researchers said they plan to conduct more studies to try to decipher exactly how the drugs work in combination with each other. They hope to move on to experiments in more complex animals, such as mice, to gauge the effects on the entire body before eventually progressing to human trials. (VOA)


Popular

IANS

The aim of the book is to teach children that families can exist in different forms, and show them how to accept the diversity in family backgrounds.

By Siddhi Jain

Delhi-based author Pritisha Borthakur is set to release her new book, 'Puhor and Niyor's Mural of Family Stories'. The 1,404-word children's book was put together to address a new kind of societal debacle in the family system. The author says the aim is to teach children that families can exist in different forms, and show them how to accept the diversity in family backgrounds.

The author who named the book after her twin sons -- Puhor and Niyor -- is a parent who has seen and heard the tales of ridicule and discrimination suffered by many in India and beyond. She says the book is an artistic illustration for kids that details how different families can live and coexist. Whether it's children with two dads or two moms, children with a single dad or single mom, and even multiracial family units, Borthakur's book teaches love, understanding, and compassion towards unconventional families.

Beyond race, gender, color, and ethnicity which have formed the bases for discrimination since the beginning of time, this book aims to bring to light a largely ignored issue. For so long, single parents have been treated like a taboo without any attempt to understand their situations; no one really cares how or why one's marriage ended but just wants to treat single parents as villains simply for choosing happiness and loving their children.

Homosexual parents, a relatively new family system, is another form that has suffered hate and discrimination for many years. Pritisha emphasizes the need to understand that diversity in people and family is what makes the world beautiful and colourful. 'Puhor and Niyor's Mural of Family Stories' is a firm but compassionate statement against all forms of discrimination on the bases of sexual identity, gender, race, and even differences in background

four children standing on dirt during daytime 'Puhor and Niyor's Mural of Family Stories' is a firm but compassionate statement against all forms of discrimination on the bases of sexual identity, gender, race and even differences in background. | Photo by Ben Wicks on Unsplash


Keep Reading Show less
Photo by Lina Trochez on Unsplash

Clean and maintained hands boost confidence in daily life activities.

If you feel that clean and well-groomed hands are just an essential prerequisite for women, you might like to think twice. Men should equally pay attention to their hands because our hand houses 1,500 bacteria living on each square centimeter of its skin. You can easily assume what havoc it can create in our body because in India we have the culture of eating with our hands and spaces beneath nails can become breeding heaven for germs. Moreover, clean and maintained hands boost confidence in their daily life activities. Therefore, it's important to keep your hands clean irrespective of your gender by washing or sanitizing at regular intervals. And, to keep them groomed, you don't have to visit a salon.

Rajesh U Pandya, Managing Director, KAI India, gives easy and completely doable tips to follow at home:

* Refrain from harsh soaps: You should be mindful of the soap you are using to wash your hands. Your soap can have a moisturizing element in it like aloe vera or shea butter. Ensure that you're washing your hands with normal water as hot water can make your hand's skin dry and scaly.

Soap bars organic You should be mindful of the soap you are using to wash your hands. | Photo by Aurélia Dubois on Unsplash

Keep Reading Show less
Photo by Dmitry Demidko on Unsplash

Bitcoin has become an essential crypto asset in modern portfolios and investment funds.

Bitcoin has become an essential crypto asset in modern portfolios and investment funds. The confidence generated in this cryptocurrency will depend a lot on the diversification that companies make in their balance sheets in Bitcoin and the increase of institutional investors that allocate a percentage of their funds in this crypto. American fund manager Cathie Wood makes some interesting predictions, both in the rise that the Bitcoin price will experience in the next 5 years, suggesting these institutional investors allocate 5% of their funds; this will help leverage the Bitcoin market.

Bitcoin will grow by a tenfold

Keep reading... Show less