Saturday December 7, 2019

Researchers to Figure Out Mechanism of Aging Process to Find Ways to Help People Stay Healthy for Longer

"We are not trying to cheat death, but help people be healthy and disease-free in their final years," said Linda Partridge, a professor

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Researchers, Mechanism, Aging
A fruit fly is seen in a laboratory at the Bar-Ilan University, in Ramat Gan, Israel, May 1, 2018. VOA

Scientists who gave fruit flies a triple drug combination treatment and found that it extended their lives by almost 50% say their work offers clues on how to fight aging in people. Researchers.

The researchers said their aim is not to find the secret of eternal life, but to figure out the mechanism of the aging process to find ways to help people stay healthy for longer.

“We are not trying to cheat death, but help people be healthy and disease-free in their final years,” said Linda Partridge, a professor at University College London’s Institute of Healthy Ageing and the Max Planck Institute for Biology of Ageing who co-led the work.

The three drugs – the mood stabilizer lithium, a cancer treatment called trametinib and an immune regulator called rapamycin – target different cellular processes and had a “quite remarkable” impact on the flies’ lifespans, the scientists said.

Researchers, Mechanism, Aging
The researchers said their aim is not to find the secret of eternal life, but to figure out the mechanism of the aging process to find ways to help people stay healthy for longer. Pixabay

And since the three drugs are all already in use as medical treatments, they are known to be safe to use in people, we have found that a combination drug treatment … may be an effective way to slow down the aging process,” said Jorge Castillo-Quan, who co-led the research.

Partridge said the findings add to growing evidence that so-called polypills — pills that combine low doses of multiple drugs — could one day help prevent age-related diseases.

“This may be possible by combining the drugs we’re investigating with other promising drugs, but there is a long way to go,” she said.

This research adds to previous studies finding that individually, lithium, trametinib and rapamycin can each extend lifespan in fruit flies. That evidence has also been supported by further studies in mice and worms, the scientists said.

Also Read- Eating Red Meat Links to Cancer and Heart Disease, but are the Risks Big Enough to Give Up Burgers and Steak?

In this study, published in Proceedings of the National Academy of Sciences journal, Castillo-Quan’s team gave fruit flies doses of the three drugs separately and in combination.

Each drug individually extended lifespan by an average of 11%, they found, and pairing two drugs extended lifespan by around 30%. But when all three were combined, the fruit flies lived 48% longer than flies that did not get the treatment.

“We found it was quite remarkable that this drug combination enabled them to live 48% longer,” said Castillo-Quan, who now works at Harvard Medical School in the United States.

The researchers said they plan to conduct more studies to try to decipher exactly how the drugs work in combination with each other. They hope to move on to experiments in more complex animals, such as mice, to gauge the effects on the entire body before eventually progressing to human trials. (VOA)

Next Story

Facebook, Twitter Reveal That Android Apps Accessed Users Data

Twitter and Facebook said they will notify those whose information was likely shared through apps

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Android Smartphone phone
Smartphones have become the most important gadget to own these days & Android is a mobile operating system. Pixabay

In yet another data breach, Facebook and Twitter have admitted that data of hundreds of users was improperly accessed by some third-party apps on Android Google Play Store as they logged into those apps.

Security researchers discovered that the One Audience and Mobiburn software development kits (SDK) provided access to users’ data, including email addresses, usernames, and recent tweets, on both the platforms.

Twitter and Facebook said they will notify those whose information was likely shared through apps.

“We recently received a report about a malicious mobile software development kit (SDK) maintained by One Audience. We are informing you about this today because we believe we have a responsibility to inform you of incidents that may impact the safety of your personal data or Twitter account,” the micro-blogging platform said in a statement late Monday.

The companies were notified of the vulnerability by third-party security researchers.

Android is a mobile operating system
Android is a mobile operating system based on a modified version of the Linux kernel and other open source software. Pixabay

A Facebook spokesperson told The Verge: “After investigating, we removed the apps from our platform for violating our platform policies and issued cease and desist letters against One Audience and Mobiburn”.

We plan to notify people whose information we believe was likely shared after they had granted these apps permission to access their profile information like name, email and gender”.

At the moment, it looks iOS users were not impacted.

According to Twitter, this issue is not due to a vulnerability in Twitter’s software, but rather the lack of isolation between SDKs within an application.

“We have evidence that this SDK was used to access people’s personal data for at least some Twitter account holders using Android, however, we have no evidence that the iOS version of this malicious SDK targeted people who use Twitter for iOS,” said Twitter.

Twitter has informed Google and Apple about the malicious SDK so they can take further action if needed.

Android apps in a tablet
Some of the best apps available for Android smartphones. Pixabay

“We will be directly notifying people who use Twitter for Android who may have been impacted by this issue,” it added.

Earlier this month, Facebook revealed that at least 100 app developers may have accessed Facebook users’ data for months, confirming that at least 11 partners “accessed group members” information in the last 60 days”.

ALSO READ: Facebook Turned To Privacy Champion By Embracing Encrypted Messaging

The social networking giant found that the apps – primarily social media management and video streaming apps – retained access to group member information, like names and profile pictures in connection with group activity, from the Groups API (application programming interface).

According to the company, the apps designed to make it easier for group admins to manage their groups more effectively and help members share videos to their groups. (IANS)