Tuesday January 28, 2020

Researchers Find Cells Linked to Blindness in Elderly People

This study helps pinpoint cell types that can be investigated closely to develop new types of therapeutics

0
//
Bindness
Age-related macular degeneration is one of the leading causes of Blindness in the elderly. Pixabay

A team of researchers have discovered cells that lead to progressive loss of central vision among the elderly.

Age-related macular degeneration is one of the leading causes of blindness in the elderly.

Genome-wide studies have identified almost three dozen genes that play a role in the disease, but exactly where in the eye they inflict damage was not well known.

Researchers from Yale University, the Broad Institute of the Massachusetts Institute of Technology, and Harvard University reported in the journal Nature Communications that glial cells (or support cells), and vasculature cells tasked with providing blood to the retina as well as cone cells contribute to degeneration of the macula, in the central part of the retina.

“This study helps pinpoint cell types that can be investigated closely to develop new types of therapeutics,” said Brian Hafler, assistant professor of ophthalmology and visual science and of pathology at Yale.

There are a limited number of effective long-term treatments available for the two forms of macular degeneration.

The wet form is caused by growth of abnormal blood vessels underneath the macula, which can be mitigated by regular injections in the eye.

Blindness
While genes associated with the risk of developing macular degeneration had been identified, the team used new single-cell sequencing to generate the first comprehensive human retinal atlas and employed data analysis technology to localize their effects to specific cell types associated with Blindness. Pixabay

Other than eye vitamin supplements, there is no treatment for the dry form of the disease, which is marked by accumulations of yellow deposits called drusen in the macula.

While current treatments provide some benefits, over time there can be a continued, progressive loss of vision in both forms of the disease.

While genes associated with the risk of developing macular degeneration had been identified, the team used new single-cell sequencing to generate the first comprehensive human retinal atlas and employed data analysis technology to localize their effects to specific cell types associated with the disease.

ALSO READ: Young Mothers Likely to Have Kids with ADHD: Study

While they found risk genes associated with cones, the cell type key to central vision, the researchers also found an association with glial and vascular cells — providing possible targets for novel therapies to improve and restore vision. (IANS)

Next Story

Ways to Correct Your Posture for a Healthy Life

Build better posture for good health

0
Posture
Maintaining a poor posture for long periods of time affects the natural alignment of the body and lowers energy levels. Pixabay

Poor posture can not only make you look bad but can also have adverse effects on your overall health and lifestyle.

“Maintaining poor postures for long periods of time affects the natural alignment of the body and lowers energy levels. In addition to soreness and pain in the body, poor posture can also lead to physical and mental stress.

“Postures defects can negatively influence lung function and lead to shortness of breath. Long term effects of bad posture could even impact blood circulation, digestive pattern as well as the nervous system. People who tend to slouch have also often reported having headaches,” Dr Sumalatha KB, Consultant, Physical Medicine and Rehabilitation, Aster CMI Hospital told IANSlife.

Posture
Become more mindful of your posture throughout the day, even when you are absorbed in any external activities. Pixabay

The expert shares these top tips to maintain correct postures:

1. Become more mindful of your posture throughout the day, even when you are absorbed in any external activities. Exercises focusing on the body core help immensely in retraining the body to hold itself the right way, while also increasing self-awareness of the body.

2. Exercise in the correct form, and invest in rest and recovery after a workout. Engage in muscle-strengthening exercises.

Also Read- Eating an Egg Not Linked to Heart Diseases: Study

3. It is advised to switch sitting positions, take brief walks and breaks from the computer system on your workdays. Do not stay in the sitting position for too long. Ensure you stand/walk often and stand straight while you do it. Doing this can help you prevent pain, injuries and other health problems. (IANS)